TY - JOUR
T1 - Thrombotic microangiopathy and disseminated intravascular coagulation in a patient with carcinomatosis of the bone marrow due to gastric adenocarcinoma
T2 - Case report
AU - Suarez-Reyes, Gabriel
AU - Contreras, Kateir
AU - Avila-Almanza, Fredy Alexander
AU - Salazar-Vargas, Ana Janeth
AU - Molineros-Baron, Camilo
AU - Serrano-Giraldo, Julian
N1 - Publisher Copyright:
© 2023 Gabriel Suarez-Reyes et al., published by Sciendo.
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Carcinomatosis of the bone marrow is a rare clinical condition characterized by diffuse tumor infiltration of the bone marrow accompanied by hematological abnormalities, including thrombotic microangiopathy (TMA) and disseminated intravascular coagulation (DIC). In patients with gastric carcinoma, this association is infrequent. Below we present a case of a 19-year-old female patient with no known pathological history who presented with upper digestive tract bleeding. Upon examination, anemia and thrombocytopenia were documented, with schistocytes in the peripheral blood smear and prolonged coagulation times. Endoscopic studies indicated a lesion in the Borrmann IV gastric body, and the bone marrow biopsy showed the presence of signet ring cells. Because there was no possibility of systemic therapy, the patient died during hospitalization. This case contributes to the medical literature by describing an unusual presentation of a very frequent pathology.
AB - Carcinomatosis of the bone marrow is a rare clinical condition characterized by diffuse tumor infiltration of the bone marrow accompanied by hematological abnormalities, including thrombotic microangiopathy (TMA) and disseminated intravascular coagulation (DIC). In patients with gastric carcinoma, this association is infrequent. Below we present a case of a 19-year-old female patient with no known pathological history who presented with upper digestive tract bleeding. Upon examination, anemia and thrombocytopenia were documented, with schistocytes in the peripheral blood smear and prolonged coagulation times. Endoscopic studies indicated a lesion in the Borrmann IV gastric body, and the bone marrow biopsy showed the presence of signet ring cells. Because there was no possibility of systemic therapy, the patient died during hospitalization. This case contributes to the medical literature by describing an unusual presentation of a very frequent pathology.
KW - Bone marrow diseases
KW - Disseminated intravascular coagulation
KW - gastric cancer
KW - signet ring cells
KW - thrombotic microangiopathy
UR - http://www.scopus.com/inward/record.url?scp=85167528319&partnerID=8YFLogxK
U2 - 10.2478/rjim-2023-0015
DO - 10.2478/rjim-2023-0015
M3 - Article
C2 - 37389671
AN - SCOPUS:85167528319
SN - 2501-062X
VL - 61
SP - 167
EP - 174
JO - Romanian journal of internal medicine = Revue roumaine de medecine interne
JF - Romanian journal of internal medicine = Revue roumaine de medecine interne
IS - 3
ER -
