Theoretical and conceptual proposal for appearance modeling of ossification centers in different types of flat and long bones

Luis Fernando Calixto, María Lucía Gutiérrez, Diego A. Garzón Alvarado

Research output: Contribution to journalArticlepeer-review

Abstract

A work context on the modeling of endocondral formation process in any type of ossification present in the bones of the human body was shown. Assuming that PTHrP and Ihh form a biochemical regulatory loop for the endocondral process and BMP2 and Noggin for the intramembranous one, regulatory mechanisms for this formation process were implemented. For this purpose, a set of widely used diffusion reaction equations in morphogenesis were used in which the biochemical factors are supposed to be secreted by precursor cells, mesenchymal and chondrocytes in the case of intramembranous and chondroidal respectively. It was concluded that the solution led to the denominated Turing patterns which represent these ossification processes in a highly estimated form.

Translated title of the contributionUna propuesta teórica y conceptual para el modelado de la aparición de centros de osificación en diferentes tipos de huesos planos y largos
Original languageEnglish
Pages (from-to)2-21
Number of pages20
JournalRevista Cubana de Ortopedia y Traumatologia
Volume27
Issue number1
StatePublished - 2013
Externally publishedYes

Keywords

  • Endocondral
  • Intramembranous
  • Ossification
  • Skeleton

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