TY - JOUR
T1 - The sedative activity of flavonoids from Passiflora quadrangularis is mediated through the GABAergic pathway
AU - Gazola, Andressa Corneo
AU - Costa, Geison Modesti
AU - Zucolotto, Silvana Maria
AU - Castellanos, Leonardo
AU - Ramos, Freddy Alejandro
AU - de Lima, Thereza Christina Monteiro
AU - Schenkel, Eloir Paulo
N1 - Publisher Copyright:
© 2018 Elsevier Masson SAS
PY - 2018/4
Y1 - 2018/4
N2 - The aim of this study was to investigate the sedative activity of the aqueous leaf extract of Passiflora quadrangularis, a species that is widely cultivated and consumed in South America, and to identify its main constituents and elucidate the involvement of the GABAergic pathway in its mechanism of action. The bioguided fractionation of the crude extract showed a positive relationship between the sedative activity of the extract and its flavonoids. The methods employed to identify and isolate its main flavonoids resulted in the identification of vitexin-2’’-O-xyloside, vitexin-2’’-O-glucoside, orientin-2’’-O-xyloside and orientin-2’’-O-glucoside. Vitexin-2”-O-xyloside, the major flavonoid of the extract, showed sedative activity after oral administration in mice.
AB - The aim of this study was to investigate the sedative activity of the aqueous leaf extract of Passiflora quadrangularis, a species that is widely cultivated and consumed in South America, and to identify its main constituents and elucidate the involvement of the GABAergic pathway in its mechanism of action. The bioguided fractionation of the crude extract showed a positive relationship between the sedative activity of the extract and its flavonoids. The methods employed to identify and isolate its main flavonoids resulted in the identification of vitexin-2’’-O-xyloside, vitexin-2’’-O-glucoside, orientin-2’’-O-xyloside and orientin-2’’-O-glucoside. Vitexin-2”-O-xyloside, the major flavonoid of the extract, showed sedative activity after oral administration in mice.
KW - C-glycosylflavonoids
KW - Passiflora quadrangularis
KW - Passifloraceae
KW - Passion flower
KW - Sedative
KW - Vitexin-2’’-O-xyloside
UR - http://www.scopus.com/inward/record.url?scp=85042026255&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2018.02.002
DO - 10.1016/j.biopha.2018.02.002
M3 - Article
C2 - 29454287
AN - SCOPUS:85042026255
SN - 0753-3322
VL - 100
SP - 388
EP - 393
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
ER -