Synthesis of 198Au nanoparticles sub 10 nm due optimization on local dose by Monte Carlo simulations for cancer treatment

Julián Mateo Zutta Villate; Jessika Viviana Rojas; Marc Benjamin Hahn; Jorge Anselmo Puerta

doi:10.1007/s10967-022-08355-5

Synthesis of ¹⁹⁸Au nanoparticles sub 10 nm due optimization on local dose by Monte Carlo simulations for cancer treatment

Julián Mateo Zutta Villate
, Jessika Viviana Rojas
, Marc Benjamin Hahn
, Jorge Anselmo Puerta

Department of Physics

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

To enhance the biological effects of radiation damage in cancerous cells, we present an alternative approach to the use of gold nanoparticles (AuNP), focusing on the synthesis and characterization of highly monodisperse, spherical radioactive gold nanoparticles ¹⁹⁸AuNP. The size of the AuNP size was optimized with the help of Geant4/TOPAS particle scattering simulations, and energy deposition per nm³ per decay for varying radii (2–10 nm) was evaluated. This work is the foundation for ongoing experimental work to evaluate cell death induced by ¹⁹⁸AuNP which aims for the use of radioactive gold nanoparticles in cancer treatment.

Original language	English
Pages (from-to)	3033-3041
Number of pages	9
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	331
Issue number	7
DOIs	https://doi.org/10.1007/s10967-022-08355-5
State	Published - Jul 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Dose enhancement
Nanomaterial synthesis
Neutron activation
Nuclear Medicine
Radioactive gold nanoparticles

Access to Document

10.1007/s10967-022-08355-5

Cite this

@article{cb1fc014200645b3986eea2445d6f054,

title = "Synthesis of 198Au nanoparticles sub 10 nm due optimization on local dose by Monte Carlo simulations for cancer treatment",

abstract = "To enhance the biological effects of radiation damage in cancerous cells, we present an alternative approach to the use of gold nanoparticles (AuNP), focusing on the synthesis and characterization of highly monodisperse, spherical radioactive gold nanoparticles 198AuNP. The size of the AuNP size was optimized with the help of Geant4/TOPAS particle scattering simulations, and energy deposition per nm3 per decay for varying radii (2–10 nm) was evaluated. This work is the foundation for ongoing experimental work to evaluate cell death induced by 198AuNP which aims for the use of radioactive gold nanoparticles in cancer treatment.",

keywords = "Dose enhancement, Nanomaterial synthesis, Neutron activation, Nuclear Medicine, Radioactive gold nanoparticles",

author = "Villate, \{Juli{\'a}n Mateo Zutta\} and Rojas, \{Jessika Viviana\} and Hahn, \{Marc Benjamin\} and Puerta, \{Jorge Anselmo\}",

note = "Publisher Copyright: {\textcopyright} 2022, Akad{\'e}miai Kiad{\'o}, Budapest, Hungary.",

year = "2022",

month = jul,

doi = "10.1007/s10967-022-08355-5",

language = "English",

volume = "331",

pages = "3033--3041",

journal = "Journal of Radioanalytical and Nuclear Chemistry",

issn = "0236-5731",

publisher = "Springer Nature",

number = "7",

}

TY - JOUR

T1 - Synthesis of 198Au nanoparticles sub 10 nm due optimization on local dose by Monte Carlo simulations for cancer treatment

AU - Villate, Julián Mateo Zutta

AU - Rojas, Jessika Viviana

AU - Hahn, Marc Benjamin

AU - Puerta, Jorge Anselmo

PY - 2022/7

Y1 - 2022/7

N2 - To enhance the biological effects of radiation damage in cancerous cells, we present an alternative approach to the use of gold nanoparticles (AuNP), focusing on the synthesis and characterization of highly monodisperse, spherical radioactive gold nanoparticles 198AuNP. The size of the AuNP size was optimized with the help of Geant4/TOPAS particle scattering simulations, and energy deposition per nm3 per decay for varying radii (2–10 nm) was evaluated. This work is the foundation for ongoing experimental work to evaluate cell death induced by 198AuNP which aims for the use of radioactive gold nanoparticles in cancer treatment.

AB - To enhance the biological effects of radiation damage in cancerous cells, we present an alternative approach to the use of gold nanoparticles (AuNP), focusing on the synthesis and characterization of highly monodisperse, spherical radioactive gold nanoparticles 198AuNP. The size of the AuNP size was optimized with the help of Geant4/TOPAS particle scattering simulations, and energy deposition per nm3 per decay for varying radii (2–10 nm) was evaluated. This work is the foundation for ongoing experimental work to evaluate cell death induced by 198AuNP which aims for the use of radioactive gold nanoparticles in cancer treatment.

KW - Dose enhancement

KW - Nanomaterial synthesis

KW - Neutron activation

KW - Nuclear Medicine

KW - Radioactive gold nanoparticles

UR - https://www.scopus.com/pages/publications/85131879307

U2 - 10.1007/s10967-022-08355-5

DO - 10.1007/s10967-022-08355-5

M3 - Article

AN - SCOPUS:85131879307

SN - 0236-5731

VL - 331

SP - 3033

EP - 3041

JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

IS - 7

ER -