TY - JOUR
T1 - Synthesis of 198Au nanoparticles sub 10 nm due optimization on local dose by Monte Carlo simulations for cancer treatment
AU - Villate, Julián Mateo Zutta
AU - Rojas, Jessika Viviana
AU - Hahn, Marc Benjamin
AU - Puerta, Jorge Anselmo
N1 - Publisher Copyright:
© 2022, Akadémiai Kiadó, Budapest, Hungary.
PY - 2022/7
Y1 - 2022/7
N2 - To enhance the biological effects of radiation damage in cancerous cells, we present an alternative approach to the use of gold nanoparticles (AuNP), focusing on the synthesis and characterization of highly monodisperse, spherical radioactive gold nanoparticles 198AuNP. The size of the AuNP size was optimized with the help of Geant4/TOPAS particle scattering simulations, and energy deposition per nm3 per decay for varying radii (2–10 nm) was evaluated. This work is the foundation for ongoing experimental work to evaluate cell death induced by 198AuNP which aims for the use of radioactive gold nanoparticles in cancer treatment.
AB - To enhance the biological effects of radiation damage in cancerous cells, we present an alternative approach to the use of gold nanoparticles (AuNP), focusing on the synthesis and characterization of highly monodisperse, spherical radioactive gold nanoparticles 198AuNP. The size of the AuNP size was optimized with the help of Geant4/TOPAS particle scattering simulations, and energy deposition per nm3 per decay for varying radii (2–10 nm) was evaluated. This work is the foundation for ongoing experimental work to evaluate cell death induced by 198AuNP which aims for the use of radioactive gold nanoparticles in cancer treatment.
KW - Dose enhancement
KW - Nanomaterial synthesis
KW - Neutron activation
KW - Nuclear Medicine
KW - Radioactive gold nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85131879307&partnerID=8YFLogxK
U2 - 10.1007/s10967-022-08355-5
DO - 10.1007/s10967-022-08355-5
M3 - Article
AN - SCOPUS:85131879307
SN - 0236-5731
VL - 331
SP - 3033
EP - 3041
JO - Journal of Radioanalytical and Nuclear Chemistry
JF - Journal of Radioanalytical and Nuclear Chemistry
IS - 7
ER -