Synthesis of 198Au nanoparticles sub 10 nm due optimization on local dose by Monte Carlo simulations for cancer treatment

Julián Mateo Zutta Villate, Jessika Viviana Rojas, Marc Benjamin Hahn, Jorge Anselmo Puerta

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

To enhance the biological effects of radiation damage in cancerous cells, we present an alternative approach to the use of gold nanoparticles (AuNP), focusing on the synthesis and characterization of highly monodisperse, spherical radioactive gold nanoparticles 198AuNP. The size of the AuNP size was optimized with the help of Geant4/TOPAS particle scattering simulations, and energy deposition per nm3 per decay for varying radii (2–10 nm) was evaluated. This work is the foundation for ongoing experimental work to evaluate cell death induced by 198AuNP which aims for the use of radioactive gold nanoparticles in cancer treatment.

Original languageEnglish
Pages (from-to)3033-3041
Number of pages9
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume331
Issue number7
DOIs
StatePublished - Jul 2022

Keywords

  • Dose enhancement
  • Nanomaterial synthesis
  • Neutron activation
  • Nuclear Medicine
  • Radioactive gold nanoparticles

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