TY - JOUR
T1 - Strategies for studying immune and non-immune human and canine mammary gland cancer tumour infiltrate
AU - Rodríguez-Bejarano, Oscar Hernán
AU - Roa, Leonardo
AU - Vargas-Hernández, Giovanni
AU - Botero-Espinosa, Lucía
AU - Parra-López, Carlos
AU - Patarroyo, Manuel Alfonso
N1 - Publisher Copyright:
© 2023
PY - 2024/1
Y1 - 2024/1
N2 - The tumour microenvironment (TME) is usually defined as a cell environment associated with tumours or cancerous stem cells where conditions are established affecting tumour development and progression through malignant cell interaction with non-malignant cells. The TME is made up of endothelial, immune and non-immune cells, extracellular matrix (ECM) components and signalling molecules acting specifically on tumour and non-tumour cells. Breast cancer (BC) is the commonest malignant neoplasm worldwide and the main cause of mortality in women globally; advances regarding BC study and understanding it are relevant for acquiring novel, personalised therapeutic tools. Studying canine mammary gland tumours (CMGT) is one of the most relevant options for understanding BC using animal models as they share common epidemiological, clinical, pathological, biological, environmental, genetic and molecular characteristics with human BC. In-depth, detailed investigation regarding knowledge of human BC-related TME and in its canine model is considered extremely relevant for understanding changes in TME composition during tumour development. This review addresses important aspects concerned with different methods used for studying BC- and CMGT-related TME that are important for developing new and more effective therapeutic strategies for attacking a tumour during specific evolutionary stages.
AB - The tumour microenvironment (TME) is usually defined as a cell environment associated with tumours or cancerous stem cells where conditions are established affecting tumour development and progression through malignant cell interaction with non-malignant cells. The TME is made up of endothelial, immune and non-immune cells, extracellular matrix (ECM) components and signalling molecules acting specifically on tumour and non-tumour cells. Breast cancer (BC) is the commonest malignant neoplasm worldwide and the main cause of mortality in women globally; advances regarding BC study and understanding it are relevant for acquiring novel, personalised therapeutic tools. Studying canine mammary gland tumours (CMGT) is one of the most relevant options for understanding BC using animal models as they share common epidemiological, clinical, pathological, biological, environmental, genetic and molecular characteristics with human BC. In-depth, detailed investigation regarding knowledge of human BC-related TME and in its canine model is considered extremely relevant for understanding changes in TME composition during tumour development. This review addresses important aspects concerned with different methods used for studying BC- and CMGT-related TME that are important for developing new and more effective therapeutic strategies for attacking a tumour during specific evolutionary stages.
KW - Animal model
KW - Breast cancer
KW - Canine mammary gland tumour
KW - Tumour infiltrate study
KW - Tumour microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85181112939&partnerID=8YFLogxK
U2 - 10.1016/j.bbcan.2023.189064
DO - 10.1016/j.bbcan.2023.189064
M3 - Review article
C2 - 38158026
AN - SCOPUS:85181112939
SN - 0304-419X
VL - 1879
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
IS - 1
M1 - 189064
ER -
