¿Son las hipospadias la expresión de diferentes enfermedades? MAMLD1: Un nuevo gen candidato para hipospadias

Nicolás Fernández; Jaime Pérez; Ignacio Zarante

doi:10.1016/j.uroco.2015.06.005

¿Son las hipospadias la expresión de diferentes enfermedades? MAMLD1: Un nuevo gen candidato para hipospadias

Translated title of the contribution: Is hypospadias a spectrum of different diseases? MAMLD1 gen: A new candidate gene for hypospadias

Nicolás Fernández, Jaime Pérez, Ignacio Zarante

San Ignacio University Hospital

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

Hypospadias is the result of an abnormal development of the urethra causing an ectopic and more proximal placement of the meatus in the ventral side of the penis. Recent molecular studies, and a better understanding of the normal development of the genital tubercle, have demonstrated a complex interaction between genes, hormones and the environment with the development of hypospadias. It is possible that hypospadias is the phenotypic expression of different diseases. Recently a new candidate gene for hypospadias has been discovered, called MAMLD1, which is involved in the normal production of testosterone during foetal development.

Translated title of the contribution	Is hypospadias a spectrum of different diseases? MAMLD1 gen: A new candidate gene for hypospadias
Original language	Spanish
Pages (from-to)	155-160
Number of pages	6
Journal	Urologia Colombiana
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/j.uroco.2015.06.005
State	Published - 01 Dec 2015

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title = "¿Son las hipospadias la expresi{\'o}n de diferentes enfermedades? MAMLD1: Un nuevo gen candidato para hipospadias",

abstract = "Hypospadias is the result of an abnormal development of the urethra causing an ectopic and more proximal placement of the meatus in the ventral side of the penis. Recent molecular studies, and a better understanding of the normal development of the genital tubercle, have demonstrated a complex interaction between genes, hormones and the environment with the development of hypospadias. It is possible that hypospadias is the phenotypic expression of different diseases. Recently a new candidate gene for hypospadias has been discovered, called MAMLD1, which is involved in the normal production of testosterone during foetal development.",

keywords = "Gene, Hypospadias, MAMLD1",

author = "Nicol{\'a}s Fern{\'a}ndez and Jaime P{\'e}rez and Ignacio Zarante",

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T2 - Un nuevo gen candidato para hipospadias

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AU - Pérez, Jaime

AU - Zarante, Ignacio

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Hypospadias is the result of an abnormal development of the urethra causing an ectopic and more proximal placement of the meatus in the ventral side of the penis. Recent molecular studies, and a better understanding of the normal development of the genital tubercle, have demonstrated a complex interaction between genes, hormones and the environment with the development of hypospadias. It is possible that hypospadias is the phenotypic expression of different diseases. Recently a new candidate gene for hypospadias has been discovered, called MAMLD1, which is involved in the normal production of testosterone during foetal development.

AB - Hypospadias is the result of an abnormal development of the urethra causing an ectopic and more proximal placement of the meatus in the ventral side of the penis. Recent molecular studies, and a better understanding of the normal development of the genital tubercle, have demonstrated a complex interaction between genes, hormones and the environment with the development of hypospadias. It is possible that hypospadias is the phenotypic expression of different diseases. Recently a new candidate gene for hypospadias has been discovered, called MAMLD1, which is involved in the normal production of testosterone during foetal development.

KW - Gene

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JF - Urologia Colombiana

IS - 3

ER -

¿Son las hipospadias la expresión de diferentes enfermedades? MAMLD1: Un nuevo gen candidato para hipospadias

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