Seroprevalence and seroconversion rates to SARS-CoV-2 in interns, residents, and medical doctors in a University Hospital in Bogotá, Colombia

Beatriz Ariza, Ximena Torres, Diana Salgado, Magda Cepeda, Carlos Gómez Restrepo, Julio Cesar Castellanos, Fernando Suárez-Obando, Adriana Cuellar, Claudia Cardozo, Juana Ángel, Manuel Antonio Franco

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Objectives: To determine the prevalence of antibodies to SARS-CoV-2 and the incidence of seroconversion in the first month of follow-up among interns, residents, and medical doctors attending patients at a University Hospital in Bogota (Colombia). Design or methods: A cross-sectional and a prospective study were performed during June, July, and August 2020 to assess seroprevalence and seroconversion rates using CLIA IgG for SARS-CoV-2. LFA IgG and IgM and ELFA IgM were also determined to explore concordance with CLIA IgG. Results: At baseline, 8 (2.28% 95%CI 1.16-4.43%) participants were IgG positive for SARS-CoV-2 by CLIA. At the end of the study, 21 (5.98% 95%CI 3.94-8.97%) individuals seroconverted by CLIA IgG. In all, 29 individuals had IgG by CLIA and of these 11 (3.13% 95%CI 1.76-5.52%) were asymptomatic. No associations with risk factors for infection were identified. CLIA IgG had moderate concordance (>962 samples) with LFA IgG and ELFA IgM, but minimal with LFA IgM. Conclusions: Our report is the first in Latina America on seroprevalence and seroconversion rates in medical healthcare workers. The relatively high rate (>3%) of asymptomatic health care workers with evidence of previous SARS-CoV-2 infection underscores the need to screen this population for infection to prevent infection/disease spread.

Translated title of the contributionTasas de seroprevalencia y seroconversión al SARS-CoV-2 en internos, residentes y médicos en un Hospital Universitario de Bogotá, Colombia
Original languageEnglish
Pages (from-to)145-152
Number of pages8
JournalInfectio
Volume25
Issue number3
DOIs
StatePublished - Sep 2021

Keywords

  • COVID-19
  • Health care workers
  • SARS-CoV-2
  • Seroconversion rate
  • Seroprevalence

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