Reacción a cuerpo extraño por implantación de un microchip

Introduction: passive RFID microchips are currently being implanted subcutaneously in both animals and humans for a variety of medical, forensic and commercial purposes. However, despite the fact that implantation techniques have been approved and certified, there is controversy about the potential development of neoplasms resulting from foreign body reaction as a mechanism of host response.
Objective: describe the origin and development of foreign body reaction to subcutaneous implantation of a passive RFID microchip and its potential association with neoplastic lesions. immunohistochemical techniques.
Methods: a systematic search of the literature was conducted in PubMed to obtain publications describing the histological responses (foreign body reaction) of peri-implant tissue following subcutaneous implantation of a passive RFID microchip by conventional histological and immunohistochemical techniques.
Results: twenty one publications were obtained describing lesions at peri-implant tissue, of which four dealt with neoplastic lesions of mesenchymal origin (fibrosarcomas, malignant fibrous histiocytoma, malignant schwannoma, anaplastic sarcoma and histiocytic sarcoma).
Conclusions: based on the literature reviewed and the available scientific evidence, it is not possible to determine that subcutaneous implantation of a passive RFID microchip is a risk factor for tumorigenesis.