TY - JOUR
T1 - Prevalence of actinic keratosis and its risk factors in the general population
T2 - The rotterdam study
AU - Flohil, Sophie C.
AU - Van Der Leest, Robert J.T.
AU - Dowlatshahi, Emmilia A.
AU - Hofman, Albert
AU - De Vries, Esther
AU - Nijsten, Tamar
N1 - Funding Information:
The authors thank the participants of the Rotterdam Study for their participation, and the research physicians and assistants for the data collection. We thank Loes Hollestein for statistical assistance and Robert Stern for critically reviewing the manuscript. This work was supported by The Netherlands Organization for Health Research and Development (ZonMw), project number 152001013/ VIDI 91711315.
PY - 2013/8
Y1 - 2013/8
N2 - Limited data are available on the prevalence and risk factors of actinic keratoses (AKs). Within the Rotterdam Study, full-body skin examinations were performed among participants aged 45 years or older to estimate the age-and sex-standardized prevalence of AK and its associated risk factors. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for associations between risk factors and the presence of 1-3, 4-9, and ≥10 AKs. Of the 2,061 inspected cohort members (mean age 72 years), 21% had 1-3, 9% had 4-9, and 8% had ≥10 AKs. AK prevalence was 49% (95% CI: 46-52%) for men and 28% (26-31%) for women. Male gender, older age, light pigmentation status, severe baldness, skin wrinkling, and high tendency for sunburn were significantly associated with extensive actinic damage (≥10 AKs) in the multivariate analyses. Especially bald males were at an increased risk of severe actinic skin damage (adjusted OR=7.0 (3.8-13.1)). The prevalence of AK is very high, especially among elderly bald males. The prevention and management of AK is a true challenge for patients, physicians, and health-care policymakers.
AB - Limited data are available on the prevalence and risk factors of actinic keratoses (AKs). Within the Rotterdam Study, full-body skin examinations were performed among participants aged 45 years or older to estimate the age-and sex-standardized prevalence of AK and its associated risk factors. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for associations between risk factors and the presence of 1-3, 4-9, and ≥10 AKs. Of the 2,061 inspected cohort members (mean age 72 years), 21% had 1-3, 9% had 4-9, and 8% had ≥10 AKs. AK prevalence was 49% (95% CI: 46-52%) for men and 28% (26-31%) for women. Male gender, older age, light pigmentation status, severe baldness, skin wrinkling, and high tendency for sunburn were significantly associated with extensive actinic damage (≥10 AKs) in the multivariate analyses. Especially bald males were at an increased risk of severe actinic skin damage (adjusted OR=7.0 (3.8-13.1)). The prevalence of AK is very high, especially among elderly bald males. The prevention and management of AK is a true challenge for patients, physicians, and health-care policymakers.
UR - https://www.scopus.com/pages/publications/84880328448
U2 - 10.1038/jid.2013.134
DO - 10.1038/jid.2013.134
M3 - Article
AN - SCOPUS:84880328448
SN - 0022-202X
VL - 133
SP - 1971
EP - 1978
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 8
ER -