Potential Therapies to Protect the Aging Heart Against Ischemia/Reperfusion Injury

Magda C. Díaz-Vesga, Úrsula Zúñiga-Cuevas, Andrés Ramírez-Reyes, Nicolas Herrera-Zelada, Iván Palomo, Roberto Bravo-Sagua, Jaime A. Riquelme

Research output: Contribution to journalShort surveypeer-review

10 Scopus citations

Abstract

Despite important advances in the treatment of myocardial infarction that have significantly reduced mortality, there is still an unmet need to limit the infarct size after reperfusion injury in order to prevent the onset and severity of heart failure. Multiple cardioprotective maneuvers, therapeutic targets, peptides and drugs have been developed to effectively protect the myocardium from reperfusion-induced cell death in preclinical studies. Nonetheless, the translation of these therapies from laboratory to clinical contexts has been quite challenging. Comorbidities, comedications or inadequate ischemia/reperfusion experimental models are clearly identified variables that need to be accounted for in order to achieve effective cardioprotection studies. The aging heart is characterized by altered proteostasis, DNA instability, epigenetic changes, among others. A vast number of studies has shown that multiple therapeutic strategies, such as ischemic conditioning phenomena and protective drugs are unable to protect the aged heart from myocardial infarction. In this Mini-Review, we will provide an updated state of the art concerning potential new cardioprotective strategies targeting the aging heart.

Original languageEnglish
Article number770421
JournalFrontiers in Cardiovascular Medicine
Volume8
DOIs
StatePublished - 2021

Keywords

  • aging
  • cardioprotection
  • ischemia/reperfusion injury
  • mitochondria
  • senolytics

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