Perfil de seguridad del uso de ibuprofeno oral en el cierre farmacológico del conducto arterioso persistente del prematuro

Translated title of the contribution: Oral Ibuprofen Safety Profile for Clo-sure of Patent Ductus Arteriosus in Preterm Infants

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Intravenous Ibuprofen and Indo-methacin are used for closure of patent ductus arteriosus in preterm infants, but are expensive and scarce in Colombia. Oral Ibuprofen is an effective and affordable alternative, but there are safety concerns. Objective: To describe the safety profile of oral ibuprofen in preterm in-fants treated for ductus closure. Materials andMethods: Retrospective cohort. Preterm infants with ductus and hemodynamic compromise who received oral ibuprofen. Outcomes: mortality, renal failure, upper GI bleeding and intestinal perforation. Results: Of 237 cases, 185 were in-cluded. There were 5% with renal failure, 2.7% with upper GI bleeding and 2.2% with intestinal perforations. Died 10.8%: for sepsis, 45%; for extreme immaturity, 35%, and 20%, for necro-tizing enterocolitis. Conclusions: The incidence of adverse events with oral ibuprofen was low. The main adverse event was renal failure (5%). Oral ibuprofen appears to be safe in closure of patent ductus arteriosus for preterm infants.
Translated title of the contribution Oral Ibuprofen Safety Profile for Clo-sure of Patent Ductus Arteriosus in Preterm Infants
Original languageSpanish
Pages (from-to)412-421
JournalUniversitas Médica
Volume56
Issue number4
DOIs
StatePublished - 2015

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