Abstract
Rotavirus enter their host and predominantly replicates in the small intestine. In this organ, TGF-β plays an important role in maintaining tolerance to commensal microorganisms and food. For this reason, it is probable that this citokine plays a role in modulating viral infection. Results from our laboratory have shown that in vitro human cells infected with rotavirus secrete increased levels of TGF-β and promote an attenuated T cell response, which is necessary for protective cellular immunity. In this review article, I will critically evaluate the hypothesis that rotavirus induce the production of TGF-β as an immune evasion mechanism.
| Translated title of the contribution | Role of TGF-β in rotavirus immunity |
|---|---|
| Original language | Spanish |
| Pages (from-to) | 18-26 |
| Number of pages | 9 |
| Journal | Revista de la Academia Colombiana de Ciencias Exactas, Fisicas y Naturales |
| Volume | 40 |
| Issue number | 154 |
| DOIs | |
| State | Published - 01 Jan 2016 |
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