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Neuroprotection with Estradiol in Experimental Perinatal Asphyxia: A New Approach

  • George Barreto
  • , Ezequiel Saraceno
  • , Janneth Gonzalez
  • , Rodolfo Kolliker
  • , Rocío Castilla
  • , Francisco Capani

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Perinatal asphyxia is an obstetric complication that can induce serious complications in the central nervous system. Between 15% and 20% of newborns die immediately after birth and 25% survive with varied neurological deficits such as cerebral palsy, mental retardation and developmental delay. Although different treatments have been used, thus far only hypothermia is recommended as a routine treatment in clinical practice. In this chapter we will discuss the use of estradiol and its impact on the long-term deficits induced by perinatal asphyxia.

Original languageEnglish
Title of host publicationEstrogen Effects on Traumatic Brain Injury
Subtitle of host publicationMechanisms of Neuroprotection and Repair
EditorsKelli A. Duncan
PublisherElsevier Inc.
Chapter8
Pages113-124
Number of pages12
ISBN (Electronic)9780128017074
ISBN (Print)9780128014790
DOIs
StatePublished - 08 Jan 2015

Publication series

NameEstrogen Effects on Traumatic Brain Injury: Mechanisms of Neuroprotection and Repair

Keywords

  • Estradiol
  • Hippocampus
  • Neuroprotection
  • Perinatal asphyxia
  • Striatum

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