Necrólisis epidérmica tóxica asociada al aumento de dosis de carbamacepina: presentación de un caso en un paciente geriátrico

Introduction: Stevens Johnson syndrome (SJS) and toxic epidermalnecrolysis (TEN) are rare, uncommon dermatological reactions usuallyassociated with drug use. They are characterized by damage anddetachment of the epidermis, with involvement of mucous membranes.Usually the onset of symptoms 4-28 days after the start of the medication. In the present case, the adverse reaction occurred afterthe increase in the dose of carbamazepine. Although thisassociation has been poorly described in the literature, itis important that health personnel know about this, sincethe timely withdrawal of the causative agent has prognosticimportance. Methods and results: This article describethe case of a 79-year-old patient with frontotemporaldementia, treated with carbamazepine and subsequentlywith dose adjustment at 8 days presented SJS with rapidprogression to TEN. Conclusions: The identification ofthe causative agent is vital in patients with toxicodermasand a medication previously tolerated by the patient shouldnot be ruled out as an etiological agent.