TY - JOUR
T1 - Nasturtium (Tropaeolum majus L.) sub-chronic consumption on insulin resistance and lipid profile in prediabetic subjects. A pilot study
AU - Barrantes-Martínez, Yudy V.
AU - Liévano, Martha
AU - Ruiz, Álvaro J.
AU - Cuéllar- Rios, Isabel
AU - Paola Valencia, Diana
AU - Wiesner-Reinhold, Melanie
AU - Schreiner, Monika
AU - Ballesteros-Vivas, Diego
AU - Guzmán-Pérez, Valentina
N1 - Publisher Copyright:
© 2022
PY - 2022/8
Y1 - 2022/8
N2 - Nasturtium (Tropaeolum majus L.) is a plant rich in bioactive compounds such as phenolic compounds, glucosinolates (GLS) and their hydrolyzed metabolites isothiocyanates (ITCs), which modulate signaling pathways related to lipid and carbohydrate metabolism. This randomized crossover trial explored the effect of intervention with a freeze-dried nasturtium drink on insulin response and lipid profile in prediabetic subjects. Ten (10) patients were randomly assigned to the following treatments: NT (nasturtium) and PLC (placebo) for 4 weeks and after this time the treatments were crossed for another 4 weeks. Biomarkers related to insulin resistance and lipid profile were measured at the beginning and the end of the intervention with each treatment. The consumption of 15 g NT (681 μmol of benzyl glucosinolate)/dose week for four (4) weeks resulted in a significant decrease in the concentration of LDL cholesterol (LDLc), Oxidized LDL (ox-LDL), Castelli's risk index I and II (TC/HDLc, and LDLc/HDLc) and Atherogenic Coefficient (non-HDLc)/HDLc). The results suggest that the nasturtium consumption might have a modulating effect on biomarkers related to cardiovascular disease, altered in subjects with chronic diseases, including type 2 diabetes. This study is the first in vivo study to explore the chronic effect of T. majus consumption in patients with prediabetes and shows the importance of continuing to explore this effect in studies with a larger number of participants.
AB - Nasturtium (Tropaeolum majus L.) is a plant rich in bioactive compounds such as phenolic compounds, glucosinolates (GLS) and their hydrolyzed metabolites isothiocyanates (ITCs), which modulate signaling pathways related to lipid and carbohydrate metabolism. This randomized crossover trial explored the effect of intervention with a freeze-dried nasturtium drink on insulin response and lipid profile in prediabetic subjects. Ten (10) patients were randomly assigned to the following treatments: NT (nasturtium) and PLC (placebo) for 4 weeks and after this time the treatments were crossed for another 4 weeks. Biomarkers related to insulin resistance and lipid profile were measured at the beginning and the end of the intervention with each treatment. The consumption of 15 g NT (681 μmol of benzyl glucosinolate)/dose week for four (4) weeks resulted in a significant decrease in the concentration of LDL cholesterol (LDLc), Oxidized LDL (ox-LDL), Castelli's risk index I and II (TC/HDLc, and LDLc/HDLc) and Atherogenic Coefficient (non-HDLc)/HDLc). The results suggest that the nasturtium consumption might have a modulating effect on biomarkers related to cardiovascular disease, altered in subjects with chronic diseases, including type 2 diabetes. This study is the first in vivo study to explore the chronic effect of T. majus consumption in patients with prediabetes and shows the importance of continuing to explore this effect in studies with a larger number of participants.
KW - Benzyl Isothiocyanate (BITC)
KW - Castelli's risk index I and II
KW - Lipid profile
KW - Oxidized LDL cholesterol
KW - Prediabetes
KW - Tropaeolum majus L.
UR - http://www.scopus.com/inward/record.url?scp=85134702972&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2022.105189
DO - 10.1016/j.jff.2022.105189
M3 - Article
AN - SCOPUS:85134702972
SN - 1756-4646
VL - 95
JO - Journal of Functional Foods
JF - Journal of Functional Foods
M1 - 105189
ER -