Murine model of rotavirus infection

Ningguo Feng; Manuel A. Franco; Harry B. Greenberg

doi:10.1007/978-1-4899-1828-4_35

Murine model of rotavirus infection

Ningguo Feng, Manuel A. Franco, Harry B. Greenberg

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The murine model of homologous rotavirus infection has been used to study the determinants of protection. The local IgA immune response appears to be the critical factor in generating protective immunity after natural infection. A series of knockout mice were used to evaluate the contribution of T cells and B cells to immunity and resolution from primary infection. Both arms of immune system played a role in the resolution of primary infection but antibody was much more important for prevention of reinfection.

Original language	English
Pages (from-to)	233-240
Number of pages	8
Journal	Advances in Experimental Medicine and Biology
Volume	412
DOIs	https://doi.org/10.1007/978-1-4899-1828-4_35
State	Published - 1997
Externally published	Yes

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title = "Murine model of rotavirus infection",

abstract = "The murine model of homologous rotavirus infection has been used to study the determinants of protection. The local IgA immune response appears to be the critical factor in generating protective immunity after natural infection. A series of knockout mice were used to evaluate the contribution of T cells and B cells to immunity and resolution from primary infection. Both arms of immune system played a role in the resolution of primary infection but antibody was much more important for prevention of reinfection.",

author = "Ningguo Feng and Franco, {Manuel A.} and Greenberg, {Harry B.}",

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AU - Feng, Ningguo

AU - Franco, Manuel A.

AU - Greenberg, Harry B.

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AB - The murine model of homologous rotavirus infection has been used to study the determinants of protection. The local IgA immune response appears to be the critical factor in generating protective immunity after natural infection. A series of knockout mice were used to evaluate the contribution of T cells and B cells to immunity and resolution from primary infection. Both arms of immune system played a role in the resolution of primary infection but antibody was much more important for prevention of reinfection.

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DO - 10.1007/978-1-4899-1828-4_35

M3 - Article

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SN - 0065-2598

VL - 412

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EP - 240

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

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Murine model of rotavirus infection

Abstract

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