Abstract
Introduction: Designing bio-inspired devices or molecules has been a longstanding method supporting multiple advances in science and te-chnology. Objective: To test the potential effect of intraperitoneal administration of the bio-ins-pired peptide on short-term plasticity. Materials and methods: Male rats in two groups (peptide treated and control) were used for registration of hippocampal field potentials from CA1, after paired stimuli in CA3 contra lateral area. Re-sults: Amplitude and slope of field potentials’, both before and after peptide administration, showed no changes in systemic factors (tempe-rature and heart rate), but statistical significance in short term plasticity in small inter stimuli in-terval (40 to 80 ms). Conclusion: The current re-search shows effects on paired pulse facilitation caused by peptide treatment, specifically on inter stimuli interval shorter.
| Translated title of the contribution | Changes in Short Term Hippocampal Plasticity caused by a Peptide Designed and Synthesized based on the Structure of a Conotoxine |
|---|---|
| Original language | Spanish |
| Pages (from-to) | 10-25 |
| Number of pages | 15 |
| Journal | Universitas Médica |
| Volume | 54 |
| Issue number | 1 |
| DOIs | |
| State | Published - 04 Sep 2012 |