Inestabilidad microsatelital y cáncer gástrico

Gabriela Negrete-Tobar; Alejandro González-Motta; Oscar Alberto Messa-Botero; Juan Carlos Galvis; Isabella Garciandía-Rozo; Juan Sebastián Álvarez-Martínez; Juliana Pineda-Ortega; Natalia Londoño de Vivero; Ricardo Bruges-Maya

doi:10.30944/20117582.658

Inestabilidad microsatelital y cáncer gástrico

Translated title of the contribution: Microsatellite instability and gastric cancer

Gabriela Negrete-Tobar
, Alejandro González-Motta
, Oscar Alberto Messa-Botero
, Juan Carlos Galvis
, Isabella Garciandía-Rozo
, Juan Sebastián Álvarez-Martínez
, Juliana Pineda-Ortega
, Natalia Londoño de Vivero
, Ricardo Bruges-Maya

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Microsatellite instability is caused by an alteration of the mismatch repair systems, which can affect microsatellites within the entire human genome, causing errors in their replication. Published studies, mainly in the English literature, have found that some tumors, such as gastric ones, can express microsatellite instability. In this review, a description of the mismatch repair systems and their relationship with the presence of microsatellite instability in gastric tumors is presented, as well as its possible clinical utility, as an associated factor in the response to immunotherapy treatment, in patients with gastric cancer.

Translated title of the contribution	Microsatellite instability and gastric cancer
Original language	Spanish
Pages (from-to)	120-131
Number of pages	12
Journal	Revista Colombiana de Cirugia
Volume	36
Issue number	1
DOIs	https://doi.org/10.30944/20117582.658
State	Published - 2021

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SDG 3 Good Health and Well-being

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10.30944/20117582.658

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abstract = "Microsatellite instability is caused by an alteration of the mismatch repair systems, which can affect microsatellites within the entire human genome, causing errors in their replication. Published studies, mainly in the English literature, have found that some tumors, such as gastric ones, can express microsatellite instability. In this review, a description of the mismatch repair systems and their relationship with the presence of microsatellite instability in gastric tumors is presented, as well as its possible clinical utility, as an associated factor in the response to immunotherapy treatment, in patients with gastric cancer.",

keywords = "Cancer; gastric; microsatellite instability, Immunotherapy, Treatment",

author = "Gabriela Negrete-Tobar and Alejandro Gonz{\'a}lez-Motta and Messa-Botero, \{Oscar Alberto\} and Galvis, \{Juan Carlos\} and Isabella Garciand{\'i}a-Rozo and {\'A}lvarez-Mart{\'i}nez, \{Juan Sebasti{\'a}n\} and Juliana Pineda-Ortega and \{de Vivero\}, \{Natalia Londo{\~n}o\} and Ricardo Bruges-Maya",

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doi = "10.30944/20117582.658",

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T1 - Inestabilidad microsatelital y cáncer gástrico

AU - Negrete-Tobar, Gabriela

AU - González-Motta, Alejandro

AU - Messa-Botero, Oscar Alberto

AU - Galvis, Juan Carlos

AU - Garciandía-Rozo, Isabella

AU - Álvarez-Martínez, Juan Sebastián

AU - Pineda-Ortega, Juliana

AU - de Vivero, Natalia Londoño

AU - Bruges-Maya, Ricardo

PY - 2021

Y1 - 2021

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AB - Microsatellite instability is caused by an alteration of the mismatch repair systems, which can affect microsatellites within the entire human genome, causing errors in their replication. Published studies, mainly in the English literature, have found that some tumors, such as gastric ones, can express microsatellite instability. In this review, a description of the mismatch repair systems and their relationship with the presence of microsatellite instability in gastric tumors is presented, as well as its possible clinical utility, as an associated factor in the response to immunotherapy treatment, in patients with gastric cancer.

KW - Cancer; gastric; microsatellite instability

KW - Immunotherapy

KW - Treatment

UR - https://www.scopus.com/pages/publications/85107748033

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DO - 10.30944/20117582.658

M3 - Artículo

AN - SCOPUS:85107748033

SN - 2011-7582

VL - 36

SP - 120

EP - 131

JO - Revista Colombiana de Cirugia

JF - Revista Colombiana de Cirugia

IS - 1

ER -

Inestabilidad microsatelital y cáncer gástrico

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