Immunity and correlates of protection for rotavirus vaccines

Manuel A. Franco; Juana Angel; Harry B. Greenberg

doi:10.1016/j.vaccine.2005.12.048

Immunity and correlates of protection for rotavirus vaccines

Manuel A. Franco, Juana Angel, Harry B. Greenberg

Institute of Human Genetics

Research output: Contribution to journal › Review article › peer-review

242 Scopus citations

Abstract

Rotaviruses are the most common cause of severe, dehydrating diarrhea in children worldwide. The tremendous global incidence of rotavirus gastroenteritis, especially in developing countries, emphasizes the need for vaccines to prevent associated morbidity and mortality. However, immunity to rotavirus is not completely understood. At this time, total serum RV IgA, measured shortly after infection, appears to be the best marker of protection against rotavirus. This review describes the current understanding of rotavirus immunity, including mechanisms of protection against rotavirus from selected animal models, and correlates of protection associated with natural infection or vaccination from humans.

Original language	English
Pages (from-to)	2718-2731
Number of pages	14
Journal	Vaccine
Volume	24
Issue number	15
DOIs	https://doi.org/10.1016/j.vaccine.2005.12.048
State	Published - 05 Apr 2006

Keywords

Immunity
Rotavirus
Vaccine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2005.12.048

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title = "Immunity and correlates of protection for rotavirus vaccines",

abstract = "Rotaviruses are the most common cause of severe, dehydrating diarrhea in children worldwide. The tremendous global incidence of rotavirus gastroenteritis, especially in developing countries, emphasizes the need for vaccines to prevent associated morbidity and mortality. However, immunity to rotavirus is not completely understood. At this time, total serum RV IgA, measured shortly after infection, appears to be the best marker of protection against rotavirus. This review describes the current understanding of rotavirus immunity, including mechanisms of protection against rotavirus from selected animal models, and correlates of protection associated with natural infection or vaccination from humans.",

keywords = "Immunity, Rotavirus, Vaccine",

author = "Franco, {Manuel A.} and Juana Angel and Greenberg, {Harry B.}",

note = "Funding Information: This work was supported by funds from the Pontificia Universidad Javeriana, Colciencias Grants 1203-04-12638 and 1203-04-16466, FIRCA Grants TWO5647-01 and TW005647-04 and by NIH Grants R01 AI21362-20 and Digestive Disease Center Grant DK56339 and a VA Merit Review Grant.",

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AU - Angel, Juana

AU - Greenberg, Harry B.

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N2 - Rotaviruses are the most common cause of severe, dehydrating diarrhea in children worldwide. The tremendous global incidence of rotavirus gastroenteritis, especially in developing countries, emphasizes the need for vaccines to prevent associated morbidity and mortality. However, immunity to rotavirus is not completely understood. At this time, total serum RV IgA, measured shortly after infection, appears to be the best marker of protection against rotavirus. This review describes the current understanding of rotavirus immunity, including mechanisms of protection against rotavirus from selected animal models, and correlates of protection associated with natural infection or vaccination from humans.

AB - Rotaviruses are the most common cause of severe, dehydrating diarrhea in children worldwide. The tremendous global incidence of rotavirus gastroenteritis, especially in developing countries, emphasizes the need for vaccines to prevent associated morbidity and mortality. However, immunity to rotavirus is not completely understood. At this time, total serum RV IgA, measured shortly after infection, appears to be the best marker of protection against rotavirus. This review describes the current understanding of rotavirus immunity, including mechanisms of protection against rotavirus from selected animal models, and correlates of protection associated with natural infection or vaccination from humans.

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KW - Rotavirus

KW - Vaccine

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DO - 10.1016/j.vaccine.2005.12.048

M3 - Review article

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JO - Vaccine

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ER -

Immunity and correlates of protection for rotavirus vaccines

Abstract

Keywords

UN SDGs

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