Human Acquired Immunity to Rotavirus Disease and Correlates of Protection

D. Herrera; M. Parra; M. A. Franco; J. Angel

doi:10.1016/B978-0-12-802241-2.00013-4

Human Acquired Immunity to Rotavirus Disease and Correlates of Protection

D. Herrera, M. Parra, M. A. Franco, J. Angel

Universidad Javeriana

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

This chapter reviews recent studies from this group on adaptive immune responses to rotavirus (RV) and correlates of protection against disease. The main findings are that both circulating memory RV-specific B and T cells preferentially express intestinal homing receptors, and that both types of lymphocyte populations are enriched in cells with peculiar functions: while B cells are enriched in an innate immunity subset, T cells have a poor functional profile. These characteristics are probably due to the fact that these lymphocytes are activated and proliferate in a tolerogenic intestinal microenvironment (the predominant site of RV replication), making RV infection an excellent model to study lymphocytes from the gut-associated lymphoid tissue. This knowledge may also be useful to define better correlates of protection against the disease.

Original language	English
Title of host publication	Viral Gastroenteritis
Subtitle of host publication	Molecular Epidemiology and Pathogenesis
Publisher	Elsevier Inc.
Pages	265-278
Number of pages	14
ISBN (Electronic)	9780128026595
ISBN (Print)	9780128022412
DOIs	https://doi.org/10.1016/B978-0-12-802241-2.00013-4
State	Published - 12 Jul 2016

Keywords

Rotavirus-specific SIg
Rotavirus-specific T cells
Rotavius-specific B cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-802241-2.00013-4

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title = "Human Acquired Immunity to Rotavirus Disease and Correlates of Protection",

abstract = "This chapter reviews recent studies from this group on adaptive immune responses to rotavirus (RV) and correlates of protection against disease. The main findings are that both circulating memory RV-specific B and T cells preferentially express intestinal homing receptors, and that both types of lymphocyte populations are enriched in cells with peculiar functions: while B cells are enriched in an innate immunity subset, T cells have a poor functional profile. These characteristics are probably due to the fact that these lymphocytes are activated and proliferate in a tolerogenic intestinal microenvironment (the predominant site of RV replication), making RV infection an excellent model to study lymphocytes from the gut-associated lymphoid tissue. This knowledge may also be useful to define better correlates of protection against the disease.",

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AU - Herrera, D.

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AU - Franco, M. A.

AU - Angel, J.

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N2 - This chapter reviews recent studies from this group on adaptive immune responses to rotavirus (RV) and correlates of protection against disease. The main findings are that both circulating memory RV-specific B and T cells preferentially express intestinal homing receptors, and that both types of lymphocyte populations are enriched in cells with peculiar functions: while B cells are enriched in an innate immunity subset, T cells have a poor functional profile. These characteristics are probably due to the fact that these lymphocytes are activated and proliferate in a tolerogenic intestinal microenvironment (the predominant site of RV replication), making RV infection an excellent model to study lymphocytes from the gut-associated lymphoid tissue. This knowledge may also be useful to define better correlates of protection against the disease.

AB - This chapter reviews recent studies from this group on adaptive immune responses to rotavirus (RV) and correlates of protection against disease. The main findings are that both circulating memory RV-specific B and T cells preferentially express intestinal homing receptors, and that both types of lymphocyte populations are enriched in cells with peculiar functions: while B cells are enriched in an innate immunity subset, T cells have a poor functional profile. These characteristics are probably due to the fact that these lymphocytes are activated and proliferate in a tolerogenic intestinal microenvironment (the predominant site of RV replication), making RV infection an excellent model to study lymphocytes from the gut-associated lymphoid tissue. This knowledge may also be useful to define better correlates of protection against the disease.

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KW - Rotavirus-specific T cells

KW - Rotavius-specific B cells

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SN - 9780128022412

SP - 265

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BT - Viral Gastroenteritis

PB - Elsevier Inc.

ER -

Human Acquired Immunity to Rotavirus Disease and Correlates of Protection

Abstract

Keywords

UN SDGs

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