Growth of the flat bones of the membranous neurocranium: a computational model

Translated title of the contribution: Growth of the flat bones of the membranous neurocranium: A computational model

DA Garzón-Alvarado, A González, ML Gutiérrez

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

This article assumes two stages in the formation of the bones in the calvaria, the first one takes into account the formation of the primary centers of ossification. This step counts on the differentiation from mesenchymal cells into osteoblasts. A molecular mechanism is used based on a system of reaction-diffusion between two antagonistic molecules, which are BMP2 and Noggin. To this effect we used equations whose behavior allows finding Turing patterns that determine the location of the primary centers. In the second step of the model we used a molecule that is expressed by osteoblasts, called Dxl5 and that is expressed from the osteoblasts of each flat bone. This molecule allows bone growth through its borders through cell differentiation adjacent to each bone of the skull. The model has been implemented numerically using the finite element method. The results allow us to observe a good approximation of the formation of flat bones of the membranous skull as well as the formation of fontanelles and sutures.
Translated title of the contributionGrowth of the flat bones of the membranous neurocranium: A computational model
Original languageSpanish
Article number3
Pages (from-to)655-664
Number of pages10
JournalComputer Methods and Programs in Biomedicine
Volume112
Issue number3
DOIs
StatePublished - Dec 2013

Fingerprint

Dive into the research topics of 'Growth of the flat bones of the membranous neurocranium: A computational model'. Together they form a unique fingerprint.

Cite this