Glomerulopatía membranosa con glomerulonefritis necrosante: Una asociación infrecuente

Background: the association between membranous glomerulopathy and crescentic necrotizing glomerulonephritis is infrequent: 0.4%, conferring a worst prognosis scenario. Studies that require the optimal treatment scheme are required; however, it has been described that the rapid onset of immunosuppressive therapy impacts on the preservation of renal function.Objective: to present a case in which this association is presented and has an adequate response to the the performed treatment.Methods: in this article, a case of a woman with nephrotic syndrome with a documented membranous glomerulopathy with extracapillary proliferation confirmed by renal biopsy, without evidence of autoimmunity, neoplasia or infectious process is presented. After the diagnosis, treat-ment with methylprednisolone and cyclophosphamide was started with adequate evolution, without deterioration of renal function and with improvement of proteinuria.Conclusion: the presence of extracapillary proliferation gives worse prognosis in patients with membranous glomerulopathy, The timely initiation of treatment is essential.