Fine-mapping of the 1p11.2 breast cancer susceptibility locus

Hisani N. Horne; Charles C. Chung; Han Zhang; Kai Yu; Ludmila Prokunina-Olsson; Kyriaki Michailidou; Manjeet K. Bolla; Qin Wang; Joe Dennis; John L. Hopper; Melissa C. Southey; Marjanka K. Schmidt; Annegien Broeks; Kenneth Muir; Artitaya Lophatananon; Peter A. Fasching; Matthias W. Beckmann; Olivia Fletcher; Nichola Johnson; Elinor J. Sawyer; Ian Tomlinson; Barbara Burwinkel; Frederik Marme; Pascal Guénel; Thérèse Truong; Stig E. Bojesen; Henrik Flyger; Javier Benitez; Anna González-Neira; Hoda Anton-Culver; Susan L. Neuhausen; Hermann Brenner; Volker Arndt; Alfons Meindl; Rita K. Schmutzler; Hiltrud Brauch; Ute Hamann; Heli Nevanlinna; Sofia Khan; Keitaro Matsuo; Hiroji Iwata; Thilo Dörk; Natalia V. Bogdanova; Annika Lindblom; Sara Margolin; Arto Mannermaa; Veli Matti Kosma; Georgia Chenevix-Trench; Anna H. Wu; David Ven Den Berg; Ann Smeets; Hui Zhao; Jenny Chang-Claude; Anja Rudolph; Paolo Radice; Monica Barile; Fergus J. Couch; Celine Vachon; Graham G. Giles; Roger L. Milne; Christopher A. Haiman; Loic Le Marchand; Mark S. Goldberg; Soo H. Teo; Nur A.M. Taib; Vessela Kristensen; Anne Lise Borresen-Dale; Wei Zheng; Martha Shrubsole; Robert Winqvist; Arja Jukkola-Vuorinen; Irene L. Andrulis; Julia A. Knight; Peter Devilee; Caroline Seynaeve; Montserrat García-Closas; Kamila Czene; Hatef Darabi; Antoinette Hollestelle; John W.M. Martens; Jingmei Li; Wei Lu; Xiao Ou Shu; Angela Cox; Simon S. Cross; William Blot; Qiuyin Cai; Mitul Shah; Craig Luccarini; Caroline Baynes; Patricia Harrington; Daehee Kang; Ji Yeob Choi; Mikael Hartman; Kee Seng Chia; Maria Kabisch; Diana Torres; Anna Jakubowska; Jan Lubinski; Suleeporn Sangrajrang; Paul Brennan; Susan Slager; Drakoulis Yannoukakos; Chen Yang Shen; Ming Feng Hou; Anthony Swerdlow; Nick Orr; Jacques Simard; Per Hall; Paul D.P. Pharoah; Douglas F. Easton; Stephen J. Chanock; Alison M. Dunning; Jonine D. Figueroa

doi:10.1371/journal.pone.0160316

Fine-mapping of the 1p11.2 breast cancer susceptibility locus

Hisani N. Horne
, Charles C. Chung
, Han Zhang
, Kai Yu
, Ludmila Prokunina-Olsson
, Kyriaki Michailidou
, Manjeet K. Bolla
, Qin Wang
, Joe Dennis
, John L. Hopper
, Melissa C. Southey
, Marjanka K. Schmidt
, Annegien Broeks
, Kenneth Muir
, Artitaya Lophatananon
, Peter A. Fasching
, Matthias W. Beckmann
, Olivia Fletcher
, Nichola Johnson
, Elinor J. Sawyer

Ian Tomlinson, Barbara Burwinkel, Frederik Marme, Pascal Guénel, Thérèse Truong, Stig E. Bojesen, Henrik Flyger, Javier Benitez, Anna González-Neira, Hoda Anton-Culver, Susan L. Neuhausen, Hermann Brenner, Volker Arndt, Alfons Meindl, Rita K. Schmutzler, Hiltrud Brauch, Ute Hamann, Heli Nevanlinna, Sofia Khan, Keitaro Matsuo, Hiroji Iwata, Thilo Dörk, Natalia V. Bogdanova, Annika Lindblom, Sara Margolin, Arto Mannermaa, Veli Matti Kosma, Georgia Chenevix-Trench, Anna H. Wu, David Ven Den Berg, Ann Smeets, Hui Zhao, Jenny Chang-Claude, Anja Rudolph, Paolo Radice, Monica Barile, Fergus J. Couch, Celine Vachon, Graham G. Giles, Roger L. Milne, Christopher A. Haiman, Loic Le Marchand, Mark S. Goldberg, Soo H. Teo, Nur A.M. Taib, Vessela Kristensen, Anne Lise Borresen-Dale, Wei Zheng, Martha Shrubsole, Robert Winqvist, Arja Jukkola-Vuorinen, Irene L. Andrulis, Julia A. Knight, Peter Devilee, Caroline Seynaeve, Montserrat García-Closas, Kamila Czene, Hatef Darabi, Antoinette Hollestelle, John W.M. Martens, Jingmei Li, Wei Lu, Xiao Ou Shu, Angela Cox, Simon S. Cross, William Blot, Qiuyin Cai, Mitul Shah, Craig Luccarini, Caroline Baynes, Patricia Harrington, Daehee Kang, Ji Yeob Choi, Mikael Hartman, Kee Seng Chia, Maria Kabisch, Diana Torres, Anna Jakubowska, Jan Lubinski, Suleeporn Sangrajrang, Paul Brennan, Susan Slager, Drakoulis Yannoukakos, Chen Yang Shen, Ming Feng Hou, Anthony Swerdlow, Nick Orr, Jacques Simard, Per Hall, Paul D.P. Pharoah, Douglas F. Easton, Stephen J. Chanock, Alison M. Dunning, Jonine D. Figueroa

Institute of Human Genetics

National Cancer Institute (NCI)
FDA
University of Cambridge
University of Melbourne
Antoni van Leeuwenhoek Hospital
University of Warwick
University of Manchester
Friedrich-Alexander University Erlangen-Nürnberg
University of California at Los Angeles
Institute of Cancer Research
Guy’s Hospital
University of Oxford
Heidelberg University
German Cancer Research Center
Occupational and Social Determinants of Health
APHP – Paris Saclay University
Copenhagen University Hospital – Herlev and Gentofte
University of Copenhagen
Centro de Investigación en Red de Enfermedades Raras
Centre for Biomedical Research on Rare Diseases (CIBERER)
University of California, Irvine
City of Hope National Med Center
Technical University of Munich
University of Cologne
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
University of Tübingen
Helsinki University Hospital
Kyushu University
Aichi Cancer Center Hospital and Research Institute
Hannover Medical School
Karolinska Institutet
University of Eastern Finland
Queensland Institute of Medical Research
Keck School of Medicine of USC
University Hospitals Leuven
Vesalius Research Center
KU Leuven
University of Hamburg
IRCCS Fondazione Istituto Nazionale per lo studio e la cura dei tumori - Milano
European Institute of Oncology
Mayo Clinic Rochester, MN
Cancer Council Victoria
University of Hawaii Cancer Center
McGill University
McGill University Health Centre, Royal Victoria Hospital
Sime Darby Medical Centre
University of Malaya
University of Oslo
Vanderbilt University
University of Oulu
Northern Finland Laboratory Centre NordLab
Oulu University Hospital
University of Toronto
Leiden University
Erasmus MC Cancer Institute
Shanghai Center for Disease Control and Prevention
University of Sheffield
International Epidemiology Institute
Seoul National University
National University of Singapore
National University Health System
Pomeranian Medical University in Szczecin
The National Cancer Institute
International Agency for Research on Cancer
Demokritos National Centre for Scientific Research
China Medical University Taichung
Academia Sinica - Institute of Biomedical Sciences
Kaohsiung Medical University Chung-Ho Memorial Hospital
Research Center
University of Edinburgh

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The Cancer Genetic Markers of Susceptibility genome-wide association study (GWAS) originally identified a single nucleotide polymorphism (SNP) rs11249433 at 1p11.2 associated with breast cancer risk. To fine-map this locus, we genotyped 92 SNPs in a 900kb region (120,505,799-121,481,132) flanking rs11249433 in 45,276 breast cancer cases and 48,998 controls of European, Asian and African ancestry from 50 studies in the Breast Cancer Association Consortium. Genotyping was done using iCOGS, a custom-built array. Due to the complicated nature of the region on chr1p11.2:120,300,000-120,505,798, that lies near the centromere and contains seven duplicated genomic segments, we restricted analyses to 429 SNPs excluding the duplicated regions (42 genotyped and 387 imputed). Perallelic associations with breast cancer risk were estimated using logistic regression models adjusting for study and ancestry-specific principal components. The strongest association observed was with the original identified index SNP rs11249433 (minor allele frequency (MAF) 0.402; per-allele odds ratio (OR) = 1.10, 95% confidence interval (CI) 1.08-1.13, P = 1.49 x 10^-21). The association for rs11249433 was limited to ER-positive breast cancers (test for heterogeneity P<8.41 x 10^-5). Additional analyses by other tumor characteristics showed stronger associations with moderately/well differentiated tumors and tumors of lobular histology. Although no significant eQTL associations were observed, in silico analyses showed that rs11249433 was located in a region that is likely a weak enhancer/promoter. Fine-mapping analysis of the 1p11.2 breast cancer susceptibility locus confirms this region to be limited to risk to cancers that are ER-positive.

Original language	English
Article number	e0160316
Journal	PLoS ONE
Volume	11
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0160316
State	Published - Aug 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1371/journal.pone.0160316

Cite this

Horne, H. N., Chung, C. C., Zhang, H., Yu, K., Prokunina-Olsson, L., Michailidou, K., Bolla, M. K., Wang, Q., Dennis, J., Hopper, J. L., Southey, M. C., Schmidt, M. K., Broeks, A., Muir, K., Lophatananon, A., Fasching, P. A., Beckmann, M. W., Fletcher, O., Johnson, N., ... Figueroa, J. D. (2016). Fine-mapping of the 1p11.2 breast cancer susceptibility locus. PLoS ONE, 11(8), Article e0160316. https://doi.org/10.1371/journal.pone.0160316

@article{50f98f4ccbee4e6784cddf19104767bd,

title = "Fine-mapping of the 1p11.2 breast cancer susceptibility locus",

abstract = "The Cancer Genetic Markers of Susceptibility genome-wide association study (GWAS) originally identified a single nucleotide polymorphism (SNP) rs11249433 at 1p11.2 associated with breast cancer risk. To fine-map this locus, we genotyped 92 SNPs in a 900kb region (120,505,799-121,481,132) flanking rs11249433 in 45,276 breast cancer cases and 48,998 controls of European, Asian and African ancestry from 50 studies in the Breast Cancer Association Consortium. Genotyping was done using iCOGS, a custom-built array. Due to the complicated nature of the region on chr1p11.2:120,300,000-120,505,798, that lies near the centromere and contains seven duplicated genomic segments, we restricted analyses to 429 SNPs excluding the duplicated regions (42 genotyped and 387 imputed). Perallelic associations with breast cancer risk were estimated using logistic regression models adjusting for study and ancestry-specific principal components. The strongest association observed was with the original identified index SNP rs11249433 (minor allele frequency (MAF) 0.402; per-allele odds ratio (OR) = 1.10, 95\% confidence interval (CI) 1.08-1.13, P = 1.49 x 10-21). The association for rs11249433 was limited to ER-positive breast cancers (test for heterogeneity P<8.41 x 10-5). Additional analyses by other tumor characteristics showed stronger associations with moderately/well differentiated tumors and tumors of lobular histology. Although no significant eQTL associations were observed, in silico analyses showed that rs11249433 was located in a region that is likely a weak enhancer/promoter. Fine-mapping analysis of the 1p11.2 breast cancer susceptibility locus confirms this region to be limited to risk to cancers that are ER-positive.",

author = "Horne, \{Hisani N.\} and Chung, \{Charles C.\} and Han Zhang and Kai Yu and Ludmila Prokunina-Olsson and Kyriaki Michailidou and Bolla, \{Manjeet K.\} and Qin Wang and Joe Dennis and Hopper, \{John L.\} and Southey, \{Melissa C.\} and Schmidt, \{Marjanka K.\} and Annegien Broeks and Kenneth Muir and Artitaya Lophatananon and Fasching, \{Peter A.\} and Beckmann, \{Matthias W.\} and Olivia Fletcher and Nichola Johnson and Sawyer, \{Elinor J.\} and Ian Tomlinson and Barbara Burwinkel and Frederik Marme and Pascal Gu{\'e}nel and Th{\'e}r{\`e}se Truong and Bojesen, \{Stig E.\} and Henrik Flyger and Javier Benitez and Anna Gonz{\'a}lez-Neira and Hoda Anton-Culver and Neuhausen, \{Susan L.\} and Hermann Brenner and Volker Arndt and Alfons Meindl and Schmutzler, \{Rita K.\} and Hiltrud Brauch and Ute Hamann and Heli Nevanlinna and Sofia Khan and Keitaro Matsuo and Hiroji Iwata and Thilo D{\"o}rk and Bogdanova, \{Natalia V.\} and Annika Lindblom and Sara Margolin and Arto Mannermaa and Kosma, \{Veli Matti\} and Georgia Chenevix-Trench and Wu, \{Anna H.\} and \{Ven Den Berg\}, David and Ann Smeets and Hui Zhao and Jenny Chang-Claude and Anja Rudolph and Paolo Radice and Monica Barile and Couch, \{Fergus J.\} and Celine Vachon and Giles, \{Graham G.\} and Milne, \{Roger L.\} and Haiman, \{Christopher A.\} and Marchand, \{Loic Le\} and Goldberg, \{Mark S.\} and Teo, \{Soo H.\} and Taib, \{Nur A.M.\} and Vessela Kristensen and Borresen-Dale, \{Anne Lise\} and Wei Zheng and Martha Shrubsole and Robert Winqvist and Arja Jukkola-Vuorinen and Andrulis, \{Irene L.\} and Knight, \{Julia A.\} and Peter Devilee and Caroline Seynaeve and Montserrat Garc{\'i}a-Closas and Kamila Czene and Hatef Darabi and Antoinette Hollestelle and Martens, \{John W.M.\} and Jingmei Li and Wei Lu and Shu, \{Xiao Ou\} and Angela Cox and Cross, \{Simon S.\} and William Blot and Qiuyin Cai and Mitul Shah and Craig Luccarini and Caroline Baynes and Patricia Harrington and Daehee Kang and Choi, \{Ji Yeob\} and Mikael Hartman and Chia, \{Kee Seng\} and Maria Kabisch and Diana Torres and Anna Jakubowska and Jan Lubinski and Suleeporn Sangrajrang and Paul Brennan and Susan Slager and Drakoulis Yannoukakos and Shen, \{Chen Yang\} and Hou, \{Ming Feng\} and Anthony Swerdlow and Nick Orr and Jacques Simard and Per Hall and Pharoah, \{Paul D.P.\} and Easton, \{Douglas F.\} and Chanock, \{Stephen J.\} and Dunning, \{Alison M.\} and Figueroa, \{Jonine D.\}",

year = "2016",

month = aug,

doi = "10.1371/journal.pone.0160316",

language = "English",

volume = "11",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "8",

}

Horne, HN, Chung, CC, Zhang, H, Yu, K, Prokunina-Olsson, L, Michailidou, K, Bolla, MK, Wang, Q, Dennis, J, Hopper, JL, Southey, MC, Schmidt, MK, Broeks, A, Muir, K, Lophatananon, A, Fasching, PA, Beckmann, MW, Fletcher, O, Johnson, N, Sawyer, EJ, Tomlinson, I, Burwinkel, B, Marme, F, Guénel, P, Truong, T, Bojesen, SE, Flyger, H, Benitez, J, González-Neira, A, Anton-Culver, H, Neuhausen, SL, Brenner, H, Arndt, V, Meindl, A, Schmutzler, RK, Brauch, H, Hamann, U, Nevanlinna, H, Khan, S, Matsuo, K, Iwata, H, Dörk, T, Bogdanova, NV, Lindblom, A, Margolin, S, Mannermaa, A, Kosma, VM, Chenevix-Trench, G, Wu, AH, Ven Den Berg, D, Smeets, A, Zhao, H, Chang-Claude, J, Rudolph, A, Radice, P, Barile, M, Couch, FJ, Vachon, C, Giles, GG, Milne, RL, Haiman, CA, Marchand, LL, Goldberg, MS, Teo, SH, Taib, NAM, Kristensen, V, Borresen-Dale, AL, Zheng, W, Shrubsole, M, Winqvist, R, Jukkola-Vuorinen, A, Andrulis, IL, Knight, JA, Devilee, P, Seynaeve, C, García-Closas, M, Czene, K, Darabi, H, Hollestelle, A, Martens, JWM, Li, J, Lu, W, Shu, XO, Cox, A, Cross, SS, Blot, W, Cai, Q, Shah, M, Luccarini, C, Baynes, C, Harrington, P, Kang, D, Choi, JY, Hartman, M, Chia, KS, Kabisch, M, Torres, D, Jakubowska, A, Lubinski, J, Sangrajrang, S, Brennan, P, Slager, S, Yannoukakos, D, Shen, CY, Hou, MF, Swerdlow, A, Orr, N, Simard, J, Hall, P, Pharoah, PDP, Easton, DF, Chanock, SJ, Dunning, AM & Figueroa, JD 2016, 'Fine-mapping of the 1p11.2 breast cancer susceptibility locus', PLoS ONE, vol. 11, no. 8, e0160316. https://doi.org/10.1371/journal.pone.0160316

TY - JOUR

T1 - Fine-mapping of the 1p11.2 breast cancer susceptibility locus

AU - Horne, Hisani N.

AU - Chung, Charles C.

AU - Zhang, Han

AU - Yu, Kai

AU - Prokunina-Olsson, Ludmila

AU - Michailidou, Kyriaki

AU - Bolla, Manjeet K.

AU - Wang, Qin

AU - Dennis, Joe

AU - Hopper, John L.

AU - Southey, Melissa C.

AU - Schmidt, Marjanka K.

AU - Broeks, Annegien

AU - Muir, Kenneth

AU - Lophatananon, Artitaya

AU - Fasching, Peter A.

AU - Beckmann, Matthias W.

AU - Fletcher, Olivia

AU - Johnson, Nichola

AU - Sawyer, Elinor J.

AU - Tomlinson, Ian

AU - Burwinkel, Barbara

AU - Marme, Frederik

AU - Guénel, Pascal

AU - Truong, Thérèse

AU - Bojesen, Stig E.

AU - Flyger, Henrik

AU - Benitez, Javier

AU - González-Neira, Anna

AU - Anton-Culver, Hoda

AU - Neuhausen, Susan L.

AU - Brenner, Hermann

AU - Arndt, Volker

AU - Meindl, Alfons

AU - Schmutzler, Rita K.

AU - Brauch, Hiltrud

AU - Hamann, Ute

AU - Nevanlinna, Heli

AU - Khan, Sofia

AU - Matsuo, Keitaro

AU - Iwata, Hiroji

AU - Dörk, Thilo

AU - Bogdanova, Natalia V.

AU - Lindblom, Annika

AU - Margolin, Sara

AU - Mannermaa, Arto

AU - Kosma, Veli Matti

AU - Chenevix-Trench, Georgia

AU - Wu, Anna H.

AU - Ven Den Berg, David

AU - Smeets, Ann

AU - Zhao, Hui

AU - Chang-Claude, Jenny

AU - Rudolph, Anja

AU - Radice, Paolo

AU - Barile, Monica

AU - Couch, Fergus J.

AU - Vachon, Celine

AU - Giles, Graham G.

AU - Milne, Roger L.

AU - Haiman, Christopher A.

AU - Marchand, Loic Le

AU - Goldberg, Mark S.

AU - Teo, Soo H.

AU - Taib, Nur A.M.

AU - Kristensen, Vessela

AU - Borresen-Dale, Anne Lise

AU - Zheng, Wei

AU - Shrubsole, Martha

AU - Winqvist, Robert

AU - Jukkola-Vuorinen, Arja

AU - Andrulis, Irene L.

AU - Knight, Julia A.

AU - Devilee, Peter

AU - Seynaeve, Caroline

AU - García-Closas, Montserrat

AU - Czene, Kamila

AU - Darabi, Hatef

AU - Hollestelle, Antoinette

AU - Martens, John W.M.

AU - Li, Jingmei

AU - Lu, Wei

AU - Shu, Xiao Ou

AU - Cox, Angela

AU - Cross, Simon S.

AU - Blot, William

AU - Cai, Qiuyin

AU - Shah, Mitul

AU - Luccarini, Craig

AU - Baynes, Caroline

AU - Harrington, Patricia

AU - Kang, Daehee

AU - Choi, Ji Yeob

AU - Hartman, Mikael

AU - Chia, Kee Seng

AU - Kabisch, Maria

AU - Torres, Diana

AU - Jakubowska, Anna

AU - Lubinski, Jan

AU - Sangrajrang, Suleeporn

AU - Brennan, Paul

AU - Slager, Susan

AU - Yannoukakos, Drakoulis

AU - Shen, Chen Yang

AU - Hou, Ming Feng

AU - Swerdlow, Anthony

AU - Orr, Nick

AU - Simard, Jacques

AU - Hall, Per

AU - Pharoah, Paul D.P.

AU - Easton, Douglas F.

AU - Chanock, Stephen J.

AU - Dunning, Alison M.

AU - Figueroa, Jonine D.

PY - 2016/8

Y1 - 2016/8

N2 - The Cancer Genetic Markers of Susceptibility genome-wide association study (GWAS) originally identified a single nucleotide polymorphism (SNP) rs11249433 at 1p11.2 associated with breast cancer risk. To fine-map this locus, we genotyped 92 SNPs in a 900kb region (120,505,799-121,481,132) flanking rs11249433 in 45,276 breast cancer cases and 48,998 controls of European, Asian and African ancestry from 50 studies in the Breast Cancer Association Consortium. Genotyping was done using iCOGS, a custom-built array. Due to the complicated nature of the region on chr1p11.2:120,300,000-120,505,798, that lies near the centromere and contains seven duplicated genomic segments, we restricted analyses to 429 SNPs excluding the duplicated regions (42 genotyped and 387 imputed). Perallelic associations with breast cancer risk were estimated using logistic regression models adjusting for study and ancestry-specific principal components. The strongest association observed was with the original identified index SNP rs11249433 (minor allele frequency (MAF) 0.402; per-allele odds ratio (OR) = 1.10, 95% confidence interval (CI) 1.08-1.13, P = 1.49 x 10-21). The association for rs11249433 was limited to ER-positive breast cancers (test for heterogeneity P<8.41 x 10-5). Additional analyses by other tumor characteristics showed stronger associations with moderately/well differentiated tumors and tumors of lobular histology. Although no significant eQTL associations were observed, in silico analyses showed that rs11249433 was located in a region that is likely a weak enhancer/promoter. Fine-mapping analysis of the 1p11.2 breast cancer susceptibility locus confirms this region to be limited to risk to cancers that are ER-positive.

AB - The Cancer Genetic Markers of Susceptibility genome-wide association study (GWAS) originally identified a single nucleotide polymorphism (SNP) rs11249433 at 1p11.2 associated with breast cancer risk. To fine-map this locus, we genotyped 92 SNPs in a 900kb region (120,505,799-121,481,132) flanking rs11249433 in 45,276 breast cancer cases and 48,998 controls of European, Asian and African ancestry from 50 studies in the Breast Cancer Association Consortium. Genotyping was done using iCOGS, a custom-built array. Due to the complicated nature of the region on chr1p11.2:120,300,000-120,505,798, that lies near the centromere and contains seven duplicated genomic segments, we restricted analyses to 429 SNPs excluding the duplicated regions (42 genotyped and 387 imputed). Perallelic associations with breast cancer risk were estimated using logistic regression models adjusting for study and ancestry-specific principal components. The strongest association observed was with the original identified index SNP rs11249433 (minor allele frequency (MAF) 0.402; per-allele odds ratio (OR) = 1.10, 95% confidence interval (CI) 1.08-1.13, P = 1.49 x 10-21). The association for rs11249433 was limited to ER-positive breast cancers (test for heterogeneity P<8.41 x 10-5). Additional analyses by other tumor characteristics showed stronger associations with moderately/well differentiated tumors and tumors of lobular histology. Although no significant eQTL associations were observed, in silico analyses showed that rs11249433 was located in a region that is likely a weak enhancer/promoter. Fine-mapping analysis of the 1p11.2 breast cancer susceptibility locus confirms this region to be limited to risk to cancers that are ER-positive.

UR - https://www.scopus.com/pages/publications/84991088801

U2 - 10.1371/journal.pone.0160316

DO - 10.1371/journal.pone.0160316

M3 - Article

C2 - 27556229

AN - SCOPUS:84991088801

SN - 1932-6203

VL - 11

JO - PLoS ONE

JF - PLoS ONE

IS - 8

M1 - e0160316

ER -

Fine-mapping of the 1p11.2 breast cancer susceptibility locus

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this