Abstract
Objectives and Study: Most gut-microbiota studies are focused on dietary influences on microorganism composition but high inter-individual variability that limits results interpretation and clinical relevance. We conducted a cross-sectional descriptive study to understand the influence of feeding mode on metabolites related to gut-microbiota metabolic activity.
Methods: 33 healthy term-infants (birth weight>2500g) after applying inclusion/exclusion criteria (Figure1) were recruited at one-month of age. Infant feeding was recorded using 24h recall (consumption was estimated based on the feedings/day and preparation referred by the caregiver), anthropometry measurements (expressed as SD scores using WHO-2006 growth standard data), urine and fecal samples were obtained for the metabolic analysis of short/medium/long chain organic acid analysis through gas chromatography/mass spectrometry. Infants were grouped as group A (GA: exclusive and predominantly breastfed), and group B (GB: partial breastfed infants).
Results: From 60 infants contacted 33 infants (19 (57.6%) in GA and 14 (42.4%) in GB) were eligible for urinary metabolomics and eight for paired urinary and fecal analysis. There were no significant differences in sex, neonatal and socio-demographic variables. Mean breast milk intake was 402.2mL(±94.9) in GA versus 307.1mL(±178.9) in GB. There was no significant difference in Weight/Length 0.05(±0.9SD) in GA versus GB -0.12(±1.2SD). Length/Age was significantly higher in GA 0.1(±0.9SD) versus GB -0.87(±0.9 SD), (P=0.004). Significant higher intakes of all quantified nutrients were observed in GB. Urinary profile (83 metabolites) included 14 gut-microbiota metabolites from which seven were more frequent in GB. Fecal metabolic profile (90 metabolites) showed differences in 15 metabolites between groups (sterols and medium and long fatty acids).
Conclusions: Feeding mode in the first month might influence microbiota metabolites in urine, and growth as Length/Age. These results highlight the need for further evaluation of feeding mode effect on gut-microbiota in a larger sample including longer follow-up. Acknowledgement: Granted by Pontificia Universidad Javeriana (InvestigarPUJ-ID20090).
Contact e-mail address: [email protected]
Methods: 33 healthy term-infants (birth weight>2500g) after applying inclusion/exclusion criteria (Figure1) were recruited at one-month of age. Infant feeding was recorded using 24h recall (consumption was estimated based on the feedings/day and preparation referred by the caregiver), anthropometry measurements (expressed as SD scores using WHO-2006 growth standard data), urine and fecal samples were obtained for the metabolic analysis of short/medium/long chain organic acid analysis through gas chromatography/mass spectrometry. Infants were grouped as group A (GA: exclusive and predominantly breastfed), and group B (GB: partial breastfed infants).
Results: From 60 infants contacted 33 infants (19 (57.6%) in GA and 14 (42.4%) in GB) were eligible for urinary metabolomics and eight for paired urinary and fecal analysis. There were no significant differences in sex, neonatal and socio-demographic variables. Mean breast milk intake was 402.2mL(±94.9) in GA versus 307.1mL(±178.9) in GB. There was no significant difference in Weight/Length 0.05(±0.9SD) in GA versus GB -0.12(±1.2SD). Length/Age was significantly higher in GA 0.1(±0.9SD) versus GB -0.87(±0.9 SD), (P=0.004). Significant higher intakes of all quantified nutrients were observed in GB. Urinary profile (83 metabolites) included 14 gut-microbiota metabolites from which seven were more frequent in GB. Fecal metabolic profile (90 metabolites) showed differences in 15 metabolites between groups (sterols and medium and long fatty acids).
Conclusions: Feeding mode in the first month might influence microbiota metabolites in urine, and growth as Length/Age. These results highlight the need for further evaluation of feeding mode effect on gut-microbiota in a larger sample including longer follow-up. Acknowledgement: Granted by Pontificia Universidad Javeriana (InvestigarPUJ-ID20090).
Contact e-mail address: [email protected]
| Original language | English |
|---|---|
| Number of pages | 1 |
| DOIs | |
| State | Published - 18 May 2024 |
| Event | 56th Annual Meeting of European Society for Paediatric Gastroenterologya, Hepatology and Nutrition - Milan, Italy Duration: 15 May 2024 → 18 May 2024 Conference number: 56 |
Other
| Other | 56th Annual Meeting of European Society for Paediatric Gastroenterologya, Hepatology and Nutrition |
|---|---|
| Abbreviated title | ESPGHAN |
| Country/Territory | Italy |
| City | Milan |
| Period | 15/05/24 → 18/05/24 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 2 Zero Hunger -
SDG 3 Good Health and Well-being
Keywords
- Microbiota
- growth
- mode of feeding
- metabolism
- first month
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