Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible enterococcus faecium harboring liasr substitutions

Jose M. Munita; Nagendra N. Mishra; Danya Alvarez; Truc T. Tran; Lorena Diaz; Diana Panesso; Jinnethe Reyes; Barbara E. Murray; Javier A. Adachi; Arnold S. Bayer; Cesar A. Arias

doi:10.1093/cid/ciu642

Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible enterococcus faecium harboring liasr substitutions

Jose M. Munita
, Nagendra N. Mishra
, Danya Alvarez
, Truc T. Tran
, Lorena Diaz
, Diana Panesso
, Jinnethe Reyes
, Barbara E. Murray
, Javier A. Adachi
, Arnold S. Bayer
, Cesar A. Arias

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

High-dose daptomycin (DAP) therapy failed in a neutropenic patient with bloodstream infection caused by a DAP-susceptible Enterococcus faecium (minimum inhibitory concentration, 3 μg/mL) harboring genetic changes associated with DAP resistance, with persistent bacteremia and selection of additional resistances. Daptomycin monotherapy should be used cautiously against DAP-susceptible E. faecium strains with minimum inhibitory concentrations 2 g/mL.

Original language	English
Pages (from-to)	1277-1280
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	59
Issue number	9
DOIs	https://doi.org/10.1093/cid/ciu642
State	Published - 01 Nov 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Daptomycin
Enterococcus faecium
resistance
treatment failure

Access to Document

10.1093/cid/ciu642

Cite this

Munita, J. M., Mishra, N. N., Alvarez, D., Tran, T. T., Diaz, L., Panesso, D., Reyes, J., Murray, B. E., Adachi, J. A., Bayer, A. S., & Arias, C. A. (2014). Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible enterococcus faecium harboring liasr substitutions. Clinical Infectious Diseases, 59(9), 1277-1280. https://doi.org/10.1093/cid/ciu642

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title = "Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible enterococcus faecium harboring liasr substitutions",

abstract = "High-dose daptomycin (DAP) therapy failed in a neutropenic patient with bloodstream infection caused by a DAP-susceptible Enterococcus faecium (minimum inhibitory concentration, 3 μg/mL) harboring genetic changes associated with DAP resistance, with persistent bacteremia and selection of additional resistances. Daptomycin monotherapy should be used cautiously against DAP-susceptible E. faecium strains with minimum inhibitory concentrations 2 g/mL.",

keywords = "Daptomycin, Enterococcus faecium, resistance, treatment failure",

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doi = "10.1093/cid/ciu642",

language = "English",

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AU - Munita, Jose M.

AU - Mishra, Nagendra N.

AU - Alvarez, Danya

AU - Tran, Truc T.

AU - Diaz, Lorena

AU - Panesso, Diana

AU - Reyes, Jinnethe

AU - Murray, Barbara E.

AU - Adachi, Javier A.

AU - Bayer, Arnold S.

AU - Arias, Cesar A.

PY - 2014/11/1

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AB - High-dose daptomycin (DAP) therapy failed in a neutropenic patient with bloodstream infection caused by a DAP-susceptible Enterococcus faecium (minimum inhibitory concentration, 3 μg/mL) harboring genetic changes associated with DAP resistance, with persistent bacteremia and selection of additional resistances. Daptomycin monotherapy should be used cautiously against DAP-susceptible E. faecium strains with minimum inhibitory concentrations 2 g/mL.

KW - Daptomycin

KW - Enterococcus faecium

KW - resistance

KW - treatment failure

UR - https://www.scopus.com/pages/publications/84907049035

U2 - 10.1093/cid/ciu642

DO - 10.1093/cid/ciu642

M3 - Article

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AN - SCOPUS:84907049035

SN - 1058-4838

VL - 59

SP - 1277

EP - 1280

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 9

ER -

Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible enterococcus faecium harboring liasr substitutions

Abstract

UN SDGs

Keywords

Access to Document

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