TY - JOUR
T1 - Factors Associated With Hospitalization or Intensive Care Admission in Children With COVID-19 in Latin America
AU - López-Medina, Eduardo
AU - Camacho-Moreno, German
AU - Brizuela, Martin E.
AU - Dávalos, Diana M.
AU - Torres, Juan Pablo
AU - Ulloa-Gutierrez, Rolando
AU - López, Pio
AU - Debbag, Roberto
AU - Pérez, Paola
AU - Patiño, Jaime
AU - Norero, Ximena
AU - Mariño, Cristina
AU - Luengas, Miguel A.
AU - Ensinck, Gabriela
AU - Daza, Carlos
AU - Luciani, Kathia
AU - Quintana Kuhner, Paola
AU - Rodriguez, Mónica
AU - Rodríguez-Auad, Juan Pablo
AU - Estrada-Villarroel, Alejandra
AU - Carnevale, Mayli
AU - Mantese, Orlando Cesar
AU - Berezin, Eitan N.
AU - Castillo, José Iván
AU - Mascareñas, Abiel
AU - Jimenez-Zambrano, Andrea
AU - Dueñas, Lourdes
AU - Melgar, Mario
AU - Galvez, Nancy
AU - Cantor, Erika
AU - Asturias, Edwin J.
N1 - Publisher Copyright:
Copyright © 2022 López-Medina, Camacho-Moreno, Brizuela, Dávalos, Torres, Ulloa-Gutierrez, López, Debbag, Pérez, Patiño, Norero, Mariño, Luengas, Ensinck, Daza, Luciani, Quintana Kuhner, Rodriguez, Rodríguez-Auad, Estrada-Villarroel, Carnevale, Mantese, Berezin, Castillo, Mascareñas, Jimenez-Zambrano, Dueñas, Melgar, Galvez, Cantor and Asturias.
PY - 2022/4/14
Y1 - 2022/4/14
N2 - Background: Limited data is available from low-middle and upper-middle income countries of the factors associated with hospitalization or admission to pediatric intensive care unit (PICU) for children with COVID-19. Objective: To describe the factors associated with hospitalization or PICU admission of children with COVID-19 in Latin America. Method: Multicenter, analytical, retrospective study of children reported from 10 different Latin American countries to the Latin-American Society of Pediatric Infectious Diseases (SLIPE-COVID) research network from June 1, 2020, and February 28, 2021. Outpatient or hospitalized children <18 years of age with COVID-19 confirmed by polymerase chain reaction or antigen detection from the nasopharynx were included. Children with multisystem inflammatory syndrome in children (MIS-C) were excluded. Associations were assessed using univariate and multivariable logistic regression models. Results: A total of 1063 children with COVID-19 were included; 500 (47%) hospitalized, with 419 (84%) to the pediatric wards and 81 (16%) to the ICU. In multivariable analyses, age <1 year (Odds Ratio [OR] 1.78; 95% CI 1.08–2.94), native race (OR 5.40; 95% CI 2.13–13.69) and having a co-morbid condition (OR 5.3; 95% CI 3.10–9.15), were associated with hospitalization. Children with metabolic or endocrine disorders (OR 4.22; 95% CI 1.76–10.11), immune deficiency (1.91; 95% CI 1.05–3.49), preterm birth (OR 2.52; 95% CI 1.41–4.49), anemia at presentation (OR 2.34; 95% CI 1.28–4.27), radiological peribronchial wall thickening (OR 2.59; 95% CI 1.15–5.84) and hypoxia, altered mental status, seizures, or shock were more likely to require PICU admission. The presence of pharyngitis (OR 0.34; 95% CI 0.25–0.48); myalgia (OR 0.47; 95% CI 0.28–0.79) or diarrhea (OR 0.38; 95% CI 0.21–0.67) were inversely associated with hospital admission. Conclusions: In this data analysis reported to the SLIPE research network in Latin America, infants, social inequalities, comorbidities, anemia, bronchial wall thickening and specific clinical findings on presentation were associated with higher rates of hospitalization or PICU admission. This evidence provides data for prioritization prevention and treatment strategies for children suffering from COVID-19.
AB - Background: Limited data is available from low-middle and upper-middle income countries of the factors associated with hospitalization or admission to pediatric intensive care unit (PICU) for children with COVID-19. Objective: To describe the factors associated with hospitalization or PICU admission of children with COVID-19 in Latin America. Method: Multicenter, analytical, retrospective study of children reported from 10 different Latin American countries to the Latin-American Society of Pediatric Infectious Diseases (SLIPE-COVID) research network from June 1, 2020, and February 28, 2021. Outpatient or hospitalized children <18 years of age with COVID-19 confirmed by polymerase chain reaction or antigen detection from the nasopharynx were included. Children with multisystem inflammatory syndrome in children (MIS-C) were excluded. Associations were assessed using univariate and multivariable logistic regression models. Results: A total of 1063 children with COVID-19 were included; 500 (47%) hospitalized, with 419 (84%) to the pediatric wards and 81 (16%) to the ICU. In multivariable analyses, age <1 year (Odds Ratio [OR] 1.78; 95% CI 1.08–2.94), native race (OR 5.40; 95% CI 2.13–13.69) and having a co-morbid condition (OR 5.3; 95% CI 3.10–9.15), were associated with hospitalization. Children with metabolic or endocrine disorders (OR 4.22; 95% CI 1.76–10.11), immune deficiency (1.91; 95% CI 1.05–3.49), preterm birth (OR 2.52; 95% CI 1.41–4.49), anemia at presentation (OR 2.34; 95% CI 1.28–4.27), radiological peribronchial wall thickening (OR 2.59; 95% CI 1.15–5.84) and hypoxia, altered mental status, seizures, or shock were more likely to require PICU admission. The presence of pharyngitis (OR 0.34; 95% CI 0.25–0.48); myalgia (OR 0.47; 95% CI 0.28–0.79) or diarrhea (OR 0.38; 95% CI 0.21–0.67) were inversely associated with hospital admission. Conclusions: In this data analysis reported to the SLIPE research network in Latin America, infants, social inequalities, comorbidities, anemia, bronchial wall thickening and specific clinical findings on presentation were associated with higher rates of hospitalization or PICU admission. This evidence provides data for prioritization prevention and treatment strategies for children suffering from COVID-19.
KW - COVID-19
KW - SARS-CoV-2
KW - children
KW - critical care
KW - hospitalization
UR - https://www.scopus.com/pages/publications/85128960754
U2 - 10.3389/fped.2022.868297
DO - 10.3389/fped.2022.868297
M3 - Article
AN - SCOPUS:85128960754
SN - 2296-2360
VL - 10
JO - Frontiers in Pediatrics
JF - Frontiers in Pediatrics
M1 - 868297
ER -
SDG 3 Good Health and Well-being