Factores asociados a neumonía en organización tras infección respiratoria por SARS-CoV2

Introduction: Organizing pneumonia (OP) after SARS-CoV-2 is a sequel that impacts the recovery of patients; however, it is not clear which factors are associated with its development. Methods: Retrospective case-control study in adults with SARS-CoV-2 pneumonia for at least fourteen days, managed at the San Ignacio Hospital, Bogotá (Colombia). The clinical, paraclinical characteristics and outcomes were compared between patients who developed OP criteria (cases) and those who did not (controls). Factors associated with OP were evaluated. Results: 148 patients were included: 74 cases and 74 controls (age 57.8 ± 12.6 years; 62.2% men). The most frequent radiological pattern of OP was classic (70%). The controls had a more severe infection according to the News Score 2 > 6 points (67.6 vs. 52.7%; p = 0.002) and a higher mortality rate (13.5 vs. 4.1%; p = 0.04). After multivariate analysis, the only variable associated with OP was pneumonia with moderate severity by News Score (OR = 6.55; 95% CI: 1.76–24.4; p = 0.005). Conclusions: Moderate severity on admission is associated with OP. No other variable seems to be associated with its development. This might be explained by theories that propose that the pattern of lung injury in COVID-19 itself might be a spectrum of organizing pneumonia. New studies will be required to assess the impact of OP on these patients.