TY - JOUR
T1 - Expert consensus on evidence-based recommendations for the diagnosis, treatment, and follow-up of X-linked hypophosphatemic rickets (XLH)
AU - Cárdenas-Aguilera, Juan Guillermo
AU - Medina-Orjuela, Adriana
AU - Meza-Martínez, Adriana Isabel
AU - Prieto, Juan Carlos
AU - Zarante-Bahamón, Ana María
AU - Cáceres-Mosquera, Jimena Adriana
AU - Mejía-Gaviria, Natalia
AU - Serrano-Gayubo, Ana Katherina
AU - Baquero-Rodríguez, Richard
AU - Chacón-Acevedo, Kelly
AU - Guerrero-Tinoco, Gustavo Adolfo
AU - Uribe-Ríos, Alejandro
AU - García-Rueda, María Fernanda
AU - Abad-Londoño, Verónica
AU - Nossa-Almanza, Sergio Alejandro
AU - Aroca-Martínez, Gustavo
AU - Román-González, Alejandro
AU - Endo-Cáceres, Jorge Alberto
AU - Llano-Linares, Juan Pablo
AU - Florenzano, Pablo
AU - Díaz-Curiel, Manuel
AU - Vaisbich, María Helena
AU - Zanchetta, María Belen
AU - Guerra-Hernández, Norma Elizabeth
AU - Stefano, Eduardo Enrique
AU - Brunetto, Oscar
N1 - Publisher Copyright:
© 2024, Asociacion Colombiana de Nefrologia e Hipertension Arterial. All rights reserved.
PY - 2024
Y1 - 2024
N2 - Introduction: X-linked hypophosphatemic rickets is a hereditary condition causing disruptions in bone mineral homeostasis. The morbidity associated with this condition has exhibited variability in previous decades, possibly stemming from variations in case definitions and diagnostic confirmation procedures. Objective: Our aim was to generate evidence-informed recommendations for the diagnosis, treatment, and follow-up of patients with suspected or diagnosed XLH. Methodology: Integration of a literature review with a modified Delphi method, guided by expert consensus. Results: Following the screening and selection of 1041 documents, 41 were chosen to address the queries posed by the developer group. Experts, consulted through a modified Delphi consensus, endorsed 97 recommendations on the diagnosis, treatment, and follow-up of patients with suspected or diagnosed XLH. Notably, the quality of the evidence was deemed to be low. Conclusions: The recommendations proposed here will allow early and timely diagnosis of Xlinked hypophosphatemic rickets, while optimizing resources for its treatment and follow-up. In addition, it will help clarify the burden of the disease and improve health outcomes for this population.
AB - Introduction: X-linked hypophosphatemic rickets is a hereditary condition causing disruptions in bone mineral homeostasis. The morbidity associated with this condition has exhibited variability in previous decades, possibly stemming from variations in case definitions and diagnostic confirmation procedures. Objective: Our aim was to generate evidence-informed recommendations for the diagnosis, treatment, and follow-up of patients with suspected or diagnosed XLH. Methodology: Integration of a literature review with a modified Delphi method, guided by expert consensus. Results: Following the screening and selection of 1041 documents, 41 were chosen to address the queries posed by the developer group. Experts, consulted through a modified Delphi consensus, endorsed 97 recommendations on the diagnosis, treatment, and follow-up of patients with suspected or diagnosed XLH. Notably, the quality of the evidence was deemed to be low. Conclusions: The recommendations proposed here will allow early and timely diagnosis of Xlinked hypophosphatemic rickets, while optimizing resources for its treatment and follow-up. In addition, it will help clarify the burden of the disease and improve health outcomes for this population.
KW - Consensus
KW - Diagnosis
KW - Fibroblast Growth Factor-23
KW - Hypophosphatemic
KW - Rickets
KW - Therapeutics
UR - http://www.scopus.com/inward/record.url?scp=85186914607&partnerID=8YFLogxK
U2 - 10.22265/acnef.11.1.754
DO - 10.22265/acnef.11.1.754
M3 - Article
AN - SCOPUS:85186914607
SN - 2389-7708
VL - 11
JO - Revista Colombiana de Nefrologia
JF - Revista Colombiana de Nefrologia
IS - 1
M1 - e754
ER -