Abstract
Background: Gestational infections leading to prenatal conditions are a significant public health problem, especially in developing countries, since infectious agents can affect fetal development, which could be associated with disability and fetal death.
Objectives and Methods: To determine the association between gestational infections and the development of congenital abnormalities. An analytical case-control study was conducted, with analysis of qualitative and quantitative variables using data collected by the Surveillance and Follow-up Program for Congenital Anomalies of Bogotá (PVSACB), with data self-reported by mothers and collected through the ECLAMC record in 23 hospitals in Bogotá D.C. during the period 2001-2018.
Results: A total of 474 699 births were registered in Bogotá, D.C., with 4 220 cases and 5 771 controls (1:1.36 ratio), including newborns whose mothers were or were not exposed to infections during pregnancy. Bacterial infections were found to be associated with congenital abnormalities in the craniofacial (OR: 1.45-IC:0.82-2.57), musculoskeletal (OR:1.21-IC:1.06-1.41), nervous (OR:1.45-IC:1.14-1.84), oral region (OR:1.51-IC:1.14-2.0) and renal system (OR:1.26-IC:0.93-1.71). Those of viral origin are associated with musculoskeletal (OR:3.18-IC:1.78-5.69), nervous (OR:2.42-IC:1.03-5.68), oral region (OR:1.67-IC:0.52-5.41) and renal systems. (3.95-CI:1.67-9.33).
Conclusions: The gestational infections most associated with congenital abnormalities were bacterial and viral. Maternal genitourinary and respiratory infections were the most frequent. It is vital to delve into the association of disorders by etiological agents and the development of congenital disabilities to find strategies for opportune maternal management to reduce one of the country's leading causes of infant morbidity and mortality.
Objectives and Methods: To determine the association between gestational infections and the development of congenital abnormalities. An analytical case-control study was conducted, with analysis of qualitative and quantitative variables using data collected by the Surveillance and Follow-up Program for Congenital Anomalies of Bogotá (PVSACB), with data self-reported by mothers and collected through the ECLAMC record in 23 hospitals in Bogotá D.C. during the period 2001-2018.
Results: A total of 474 699 births were registered in Bogotá, D.C., with 4 220 cases and 5 771 controls (1:1.36 ratio), including newborns whose mothers were or were not exposed to infections during pregnancy. Bacterial infections were found to be associated with congenital abnormalities in the craniofacial (OR: 1.45-IC:0.82-2.57), musculoskeletal (OR:1.21-IC:1.06-1.41), nervous (OR:1.45-IC:1.14-1.84), oral region (OR:1.51-IC:1.14-2.0) and renal system (OR:1.26-IC:0.93-1.71). Those of viral origin are associated with musculoskeletal (OR:3.18-IC:1.78-5.69), nervous (OR:2.42-IC:1.03-5.68), oral region (OR:1.67-IC:0.52-5.41) and renal systems. (3.95-CI:1.67-9.33).
Conclusions: The gestational infections most associated with congenital abnormalities were bacterial and viral. Maternal genitourinary and respiratory infections were the most frequent. It is vital to delve into the association of disorders by etiological agents and the development of congenital disabilities to find strategies for opportune maternal management to reduce one of the country's leading causes of infant morbidity and mortality.
| Original language | Spanish |
|---|---|
| Article number | e484 |
| Journal | Pediatría |
| Volume | 57 |
| Issue number | 3 |
| DOIs | |
| State | Published - 20 Aug 2024 |
