TY - JOUR
T1 - Eriptosis
T2 - Mecanismos moleculares y su implicación en la enfermedad aterotrombótica
AU - Manzur-Jattin, Fernando
AU - Álvarez-Ortega, Neda
AU - Moneriz-Pretell, Carlos
AU - Corrales-Santander, Hugo
AU - Cantillo-García, Kevin
N1 - Publisher Copyright:
© 2015 Sociedad Colombiana de Cardiología y Cirugía Cardiovascular.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Introduction: Eryptosis has been described as programmed process of cellular death in erythrocytes before old age. It can be triggered, among other factors, by situations such as osmotic stress, oxidative stress or exposure to heavy metals. Several studies suggest that erythrocytes can play an active role in normal or abnormal haemostasis in certain conditions where the membrane of these cells is perturbed. Objetive: To describe the mechanisms involved in eryptosis and their close relationship with the processes of adhesion to the vascular wall that entail the thrombotic disease. Methods: A narrative review was carried out from the literature found in data base PubMed and Science Direct by using the key words. 51 original articles, 20 literature reviews and one case study complying with the requirements were selected. Abstracts were reviewed separately and independently. Complete publications were then located for review. Conclusions: Eryptosis is characterised by the decrease in cell volume, the vesiculation and the translocation of phosphatidylserine towards the outer surface of the plasma membrane. Disorders in the distribution of the phospholipids favour processes of cell adhesion to the vascular wall, causing impairment of microcirculation, which can result in important cardiovascular diseases. Understanding and clarifying eryptosis could be essential for finding new therapeutic targets, aimed at offering other pharmacological alternatives for the treatment of cardiovascular diseases.
AB - Introduction: Eryptosis has been described as programmed process of cellular death in erythrocytes before old age. It can be triggered, among other factors, by situations such as osmotic stress, oxidative stress or exposure to heavy metals. Several studies suggest that erythrocytes can play an active role in normal or abnormal haemostasis in certain conditions where the membrane of these cells is perturbed. Objetive: To describe the mechanisms involved in eryptosis and their close relationship with the processes of adhesion to the vascular wall that entail the thrombotic disease. Methods: A narrative review was carried out from the literature found in data base PubMed and Science Direct by using the key words. 51 original articles, 20 literature reviews and one case study complying with the requirements were selected. Abstracts were reviewed separately and independently. Complete publications were then located for review. Conclusions: Eryptosis is characterised by the decrease in cell volume, the vesiculation and the translocation of phosphatidylserine towards the outer surface of the plasma membrane. Disorders in the distribution of the phospholipids favour processes of cell adhesion to the vascular wall, causing impairment of microcirculation, which can result in important cardiovascular diseases. Understanding and clarifying eryptosis could be essential for finding new therapeutic targets, aimed at offering other pharmacological alternatives for the treatment of cardiovascular diseases.
KW - Apoptosis
KW - Atherothrombosis
KW - Blood cells
KW - Cardiovascular diseases
KW - Lipids
UR - http://www.scopus.com/inward/record.url?scp=84969895401&partnerID=8YFLogxK
U2 - 10.1016/j.rccar.2015.09.004
DO - 10.1016/j.rccar.2015.09.004
M3 - Estudio breve
AN - SCOPUS:84969895401
SN - 0120-5633
VL - 23
SP - 218
EP - 226
JO - Revista Colombiana de Cardiologia
JF - Revista Colombiana de Cardiologia
IS - 3
ER -