Efficacy and safety of oral low-dose glucocorticoids in patients with estrogen-dependent primary osteoarthritis

Carlos A. Cañas; Carlos J. Osorio; Nicolás Coronel; Magda C. Cepeda; Jorge H. Izquierdo; Fabio Bonilla-Abadía

doi:10.1007/s00296-012-2603-1

Efficacy and safety of oral low-dose glucocorticoids in patients with estrogen-dependent primary osteoarthritis

Carlos A. Cañas, Carlos J. Osorio, Nicolás Coronel, Magda C. Cepeda, Jorge H. Izquierdo, Fabio Bonilla-Abadía

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Estrogen-dependent osteoarthritis (EDPOA) is a disease of perimenopausal-age women. Their manifestations are polyarticular pain with common co-morbidities (carpal tunnel syndrome, insomnia, fatigue, depression, and fibromyalgia). Based on dual role of glucocorticoids, its trophic action on the chondrocyte and its anti-inflammatory effect, we conducted a prospective interventional cohort study where we evaluate the efficacy and safety of oral low-dose GC in one hundred women with EDPOA. The pain intensity, number of tender joints as well as impact in co-morbidities were analyzed. We conclude that the use of low-dose GC in patients with EDPOA can be an effective and a safe therapeutic option.

Original language	English
Pages (from-to)	733-735
Number of pages	3
Journal	Rheumatology International
Volume	34
Issue number	5
DOIs	https://doi.org/10.1007/s00296-012-2603-1
State	Published - May 2014
Externally published	Yes

Keywords

Glucocorticoids
Menopause
Primary osteoarthritis
Steroids

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10.1007/s00296-012-2603-1

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abstract = "Estrogen-dependent osteoarthritis (EDPOA) is a disease of perimenopausal-age women. Their manifestations are polyarticular pain with common co-morbidities (carpal tunnel syndrome, insomnia, fatigue, depression, and fibromyalgia). Based on dual role of glucocorticoids, its trophic action on the chondrocyte and its anti-inflammatory effect, we conducted a prospective interventional cohort study where we evaluate the efficacy and safety of oral low-dose GC in one hundred women with EDPOA. The pain intensity, number of tender joints as well as impact in co-morbidities were analyzed. We conclude that the use of low-dose GC in patients with EDPOA can be an effective and a safe therapeutic option.",

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AU - Cañas, Carlos A.

AU - Osorio, Carlos J.

AU - Coronel, Nicolás

AU - Cepeda, Magda C.

AU - Izquierdo, Jorge H.

AU - Bonilla-Abadía, Fabio

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AB - Estrogen-dependent osteoarthritis (EDPOA) is a disease of perimenopausal-age women. Their manifestations are polyarticular pain with common co-morbidities (carpal tunnel syndrome, insomnia, fatigue, depression, and fibromyalgia). Based on dual role of glucocorticoids, its trophic action on the chondrocyte and its anti-inflammatory effect, we conducted a prospective interventional cohort study where we evaluate the efficacy and safety of oral low-dose GC in one hundred women with EDPOA. The pain intensity, number of tender joints as well as impact in co-morbidities were analyzed. We conclude that the use of low-dose GC in patients with EDPOA can be an effective and a safe therapeutic option.

KW - Glucocorticoids

KW - Menopause

KW - Primary osteoarthritis

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Efficacy and safety of oral low-dose glucocorticoids in patients with estrogen-dependent primary osteoarthritis

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Keywords

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