Abstract
Nutrition during early life is essential for brain development,
establishing the basis for neurocognitive function later in life.
Adequate nutrient intake during the first months of life plays a
critical role on neurodevelopment. It is well established that breast-
feeding, compared to formula feeding, it has been traditionally
associated with increased neurodevelopmental scores up to early
adulthood. Thus, research efforts have been focused on developing
new infant formulas closely mimicking breast milk.
The COGNIS study, is a prospective double-blind, randomized
controlled trial study, aimed to evaluate the effects of a new infant
formula on children neurodevelopment, among other outcomes,
up to 6 years of age. A total of 170 healthy term infants living in
Granada (Spain) were randomized at 0-2 months of age to receive
a standard infant formula (SF) (n=85) or an experimental infant
formula (EF) (n=85) containing milk fat globule membrane
(MFGM) components, synbiotics, long-chain polyunsaturated
fatty acids (LC-PUFAs), gangliosides, nucleotides and sialic acid.
As a control group, 50 exclusively breastfed infants (BF) were also
included in the study. Children underwent different neurocogni-
tive examinations at 3, 4, 6, 12, 18 months, 2.5, 4 and 6 years old.
Results has shown that EF formula seems to be associated to better
visual function during their first 12 months of life, less behavioral
problems at 2.5 years, beneficial long-term effects in the child’s
language at 4 years old, and neurocognitive development and brain
structure in children at 6 years old, in a similar way to breastfed
infants.
The COGNIS study is providing important information about
potential long-term beneficial effects of a new experimental infant
formula. Additionally, this study will improve general knowledge
about mechanisms underlying early nutrition programing in
humans during postnatal life and their long-term consequences.
establishing the basis for neurocognitive function later in life.
Adequate nutrient intake during the first months of life plays a
critical role on neurodevelopment. It is well established that breast-
feeding, compared to formula feeding, it has been traditionally
associated with increased neurodevelopmental scores up to early
adulthood. Thus, research efforts have been focused on developing
new infant formulas closely mimicking breast milk.
The COGNIS study, is a prospective double-blind, randomized
controlled trial study, aimed to evaluate the effects of a new infant
formula on children neurodevelopment, among other outcomes,
up to 6 years of age. A total of 170 healthy term infants living in
Granada (Spain) were randomized at 0-2 months of age to receive
a standard infant formula (SF) (n=85) or an experimental infant
formula (EF) (n=85) containing milk fat globule membrane
(MFGM) components, synbiotics, long-chain polyunsaturated
fatty acids (LC-PUFAs), gangliosides, nucleotides and sialic acid.
As a control group, 50 exclusively breastfed infants (BF) were also
included in the study. Children underwent different neurocogni-
tive examinations at 3, 4, 6, 12, 18 months, 2.5, 4 and 6 years old.
Results has shown that EF formula seems to be associated to better
visual function during their first 12 months of life, less behavioral
problems at 2.5 years, beneficial long-term effects in the child’s
language at 4 years old, and neurocognitive development and brain
structure in children at 6 years old, in a similar way to breastfed
infants.
The COGNIS study is providing important information about
potential long-term beneficial effects of a new experimental infant
formula. Additionally, this study will improve general knowledge
about mechanisms underlying early nutrition programing in
humans during postnatal life and their long-term consequences.
| Original language | English |
|---|---|
| Pages | 6 |
| Number of pages | 1 |
| DOIs | |
| State | Published - 2022 |
| Event | XXXI Congress of the Spanish Nutrition Society/Sociedad Española de Nutrición (SEÑ) - Cartagena, Spain Duration: 15 Sep 2022 → 17 Sep 2022 |
Conference
| Conference | XXXI Congress of the Spanish Nutrition Society/Sociedad Española de Nutrición (SEÑ) |
|---|---|
| Country/Territory | Spain |
| City | Cartagena |
| Period | 15/09/22 → 17/09/22 |
