Abstract
Introduction: Several human milk bioactive components such
as long-chain polyunsaturated fatty acids (LC-PUFAs) or milk fat
globule membrane (MFGM) added to infant formula, seems to be
involved in better brain maturation and development, closer to
that observed in breastfed infants.
Objectives: The aim of the present study was to determine the
effects of infant formula enriched with bioactive components on
brain function in healthy children at 2.5 years old.
Methods: 106 children participating in the COGNIS RCT
study were evaluated at 2.5 years old; 32 children were fed with
standard infant formula (SF), 39 received an infant formula
enriched with bioactive nutrients (EF) (LC-PUFAs, MFGM, syn-
biotics, gangliosides, nucleotides and sialic acid), during their first
18 months of life; and 35 were exclusively breastfed (BF). Brain
function was evaluated by continuous electroencephalogram/cog-
nitive evoked related potentials (EEG/ERP) recordings using a
64-channel Active Two BioSemi EEG system (BioSemi;
Amsterdam, Holland). We used a weighted Global Channel
Connectivity (wGCC) measure to identify the brain’s most glob-
ally connected regions. We measured a set of confounders (sex,
height, head circumference, familiar socio-economic status, BMI of
the mother before and during the pregnancy, mother and father IQ,
gestational age, type of delivery and time of maternal breastfeeding).
Non-parametric Spearman correlation was performed to evaluate
its impacts on connectivity. Bonferroni correction was used after
multiple comparisons.
Results: The t-maps for the three groups contrast. Significant
differences were observed for the SF-BF and EF-BF, but not for the
SF-EF. Differences found in wGCC were concentrated mainly in
bilateral frontal hemisphere channels. In both cases, wGCC was
lower for children fed with any of the infant formula (SF and EF)
than for those breastfed
as long-chain polyunsaturated fatty acids (LC-PUFAs) or milk fat
globule membrane (MFGM) added to infant formula, seems to be
involved in better brain maturation and development, closer to
that observed in breastfed infants.
Objectives: The aim of the present study was to determine the
effects of infant formula enriched with bioactive components on
brain function in healthy children at 2.5 years old.
Methods: 106 children participating in the COGNIS RCT
study were evaluated at 2.5 years old; 32 children were fed with
standard infant formula (SF), 39 received an infant formula
enriched with bioactive nutrients (EF) (LC-PUFAs, MFGM, syn-
biotics, gangliosides, nucleotides and sialic acid), during their first
18 months of life; and 35 were exclusively breastfed (BF). Brain
function was evaluated by continuous electroencephalogram/cog-
nitive evoked related potentials (EEG/ERP) recordings using a
64-channel Active Two BioSemi EEG system (BioSemi;
Amsterdam, Holland). We used a weighted Global Channel
Connectivity (wGCC) measure to identify the brain’s most glob-
ally connected regions. We measured a set of confounders (sex,
height, head circumference, familiar socio-economic status, BMI of
the mother before and during the pregnancy, mother and father IQ,
gestational age, type of delivery and time of maternal breastfeeding).
Non-parametric Spearman correlation was performed to evaluate
its impacts on connectivity. Bonferroni correction was used after
multiple comparisons.
Results: The t-maps for the three groups contrast. Significant
differences were observed for the SF-BF and EF-BF, but not for the
SF-EF. Differences found in wGCC were concentrated mainly in
bilateral frontal hemisphere channels. In both cases, wGCC was
lower for children fed with any of the infant formula (SF and EF)
than for those breastfed
| Original language | English |
|---|---|
| Pages | 33 |
| Number of pages | 1 |
| DOIs | |
| State | Published - 01 Sep 2022 |
| Event | XXXI Congress of the Spanish Nutrition Society/Sociedad Española de Nutrición (SEÑ) - Cartagena, Spain Duration: 15 Sep 2022 → 17 Sep 2022 |
Conference
| Conference | XXXI Congress of the Spanish Nutrition Society/Sociedad Española de Nutrición (SEÑ) |
|---|---|
| Country/Territory | Spain |
| City | Cartagena |
| Period | 15/09/22 → 17/09/22 |
