TY - JOUR
T1 - Dementia in Latin America
T2 - Paving the way toward a regional action plan
AU - Parra, Mario Alfredo
AU - Baez, Sandra
AU - Sedeño, Lucas
AU - Gonzalez Campo, Cecilia
AU - Santamaría-García, Hernando
AU - Aprahamian, Ivan
AU - Bertolucci, Paulo H.F.
AU - Bustin, Julian
AU - Camargos Bicalho, Maria Aparecida
AU - Cano-Gutierrez, Carlos
AU - Caramelli, Paulo
AU - Chaves, Marcia L.F.
AU - Cogram, Patricia
AU - Beber, Bárbara Costa
AU - Court, Felipe A.
AU - de Souza, Leonardo Cruz
AU - Custodio, Nilton
AU - Damian, Andres
AU - de la Cruz, Myriam
AU - Diehl Rodriguez, Roberta
AU - Brucki, Sonia Maria Dozzi
AU - Fajersztajn, Lais
AU - Farías, Gonzalo A.
AU - De Felice, Fernanda G.
AU - Ferrari, Raffaele
AU - de Oliveira, Fabricio Ferreira
AU - Ferreira, Sergio T.
AU - Ferretti, Ceres
AU - Figueredo Balthazar, Marcio Luiz
AU - Ferreira Frota, Norberto Anizio
AU - Fuentes, Patricio
AU - García, Adolfo M.
AU - Garcia, Patricia J.
AU - de Gobbi Porto, Fábio Henrique
AU - Duque Peñailillo, Lissette
AU - Engler, Henry Willy
AU - Maier, Irene
AU - Mata, Ignacio F.
AU - Gonzalez-Billault, Christian
AU - Lopez, Oscar L.
AU - Morelli, Laura
AU - Nitrini, Ricardo
AU - Quiroz, Yakeel T.
AU - Guerrero Barragan, Alejandra
AU - Huepe, David
AU - Pio, Fabricio Joao
AU - Suemoto, Claudia Kimie
AU - Kochhann, Renata
AU - Kochen, Silvia
AU - Kumfor, Fiona
AU - Lanata, Serggio
AU - Miller, Bruce
AU - Mansur, Leticia Lessa
AU - Hosogi, Mirna Lie
AU - Lillo, Patricia
AU - Llibre Guerra, Jorge
AU - Lira, David
AU - Lopera, Francisco
AU - Comas, Adelina
AU - Avila-Funes, José Alberto
AU - Sosa, Ana Luisa
AU - Ramos, Claudia
AU - Resende, Elisa de Paula França
AU - Snyder, Heather M.
AU - Tarnanas, Ioannis
AU - Yokoyama, Jenifer
AU - Llibre, Juan
AU - Cardona, Juan Felipe
AU - Possin, Kate
AU - Kosik, Kenneth S.
AU - Montesinos, Rosa
AU - Moguilner, Sebastian
AU - Solis, Patricia Cristina Lourdes
AU - Ferretti-Rebustini, Renata Eloah de Lucena
AU - Ramirez, Jeronimo Martin
AU - Matallana, Diana
AU - Mbakile-Mahlanza, Lingani
AU - Marques Ton, Alyne Mendonça
AU - Tavares, Ronnielly Melo
AU - Miotto, Eliane C.
AU - Muniz-Terrera, Graciela
AU - Muñoz-Nevárez, Luis Arnoldo
AU - Orozco, David
AU - Okada de Oliveira, Maira
AU - Piguet, Olivier
AU - Pintado Caipa, Maritza
AU - Piña Escudero, Stefanie Danielle
AU - Schilling, Lucas Porcello
AU - Rodrigues Palmeira, André Luiz
AU - Yassuda, Mônica Sanches
AU - Santacruz-Escudero, Jose Manuel
AU - Serafim, Rodrigo Bernardo
AU - Smid, Jerusa
AU - Slachevsky, Andrea
AU - Serrano, Cecilia
AU - Soto-Añari, Marcio
AU - Takada, Leonel Tadao
AU - Grinberg, Lea Tenenholz
AU - Teixeira, Antonio Lucio
AU - Barbosa, Maira Tonidandel
AU - Trépel, Dominic
AU - Ibanez, Agustin
N1 - Publisher Copyright:
© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.
PY - 2021/2
Y1 - 2021/2
N2 - Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.
AB - Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.
KW - Latin America
KW - biomarkers
KW - clinical trials
KW - dementia
KW - epidemiology
KW - evidence-based recommendations
KW - genetics
KW - knowledge to action framework
KW - networking and translational research
KW - nonpharmacological interventions
UR - https://www.scopus.com/pages/publications/85095422362
U2 - 10.1002/alz.12202
DO - 10.1002/alz.12202
M3 - Article
C2 - 33634602
AN - SCOPUS:85095422362
SN - 1552-5260
VL - 17
SP - 295
EP - 313
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 2
ER -
SDG 3 Good Health and Well-being