DELIVERY OF THERAPEUTIC AGENTS TO THE BONE

Tomatsu Shunji; Adriana M Montano-suarez; Carlos J Almeciga-diaz; Barrera Luis

DELIVERY OF THERAPEUTIC AGENTS TO THE BONE

Tomatsu Shunji (Inventor)
, Adriana M Montano-suarez (Inventor)
, Carlos J Almeciga-diaz (Inventor)
, Barrera Luis (Inventor)

Saint Louis University

Research output: Innovation Products › Invention patent

Abstract

This invention relates to compositions and methods of delivering therapeutic agents to bone. More specifically, the invention relates to endowing a large molecule vectors i.e., adeno virus, retrovirus, liposomes, micelles, natural and synthetic polymers, or combinations thereof, with the ability to target bone tissue in vivo and with improved stability in the blood, by attaching multiple copies of acid amino acid peptides. One preferred embodiment of the invention relates to endowing an adeno-associated virus (AAV) vector with the ability to target bone-tissue in vivo and improve its stability, by the addition of multiple acidic amino acid peptides attached to the capsid of the viral vector.

Original language	English
Publication/registration number	US 2010/0008979 A1
International Classification	A61K9/127,A61K31/7088,A61K35/76,A61K38/02,A61K38/46,C12N7/00
Grant date	05/07/11
Filing date	03/07/09
State	Published - 14 Jan 2010
Externally published	Yes

Cite this

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title = "DELIVERY OF THERAPEUTIC AGENTS TO THE BONE",

abstract = "This invention relates to compositions and methods of delivering therapeutic agents to bone. More specifically, the invention relates to endowing a large molecule vectors i.e., adeno virus, retrovirus, liposomes, micelles, natural and synthetic polymers, or combinations thereof, with the ability to target bone tissue in vivo and with improved stability in the blood, by attaching multiple copies of acid amino acid peptides. One preferred embodiment of the invention relates to endowing an adeno-associated virus (AAV) vector with the ability to target bone-tissue in vivo and improve its stability, by the addition of multiple acidic amino acid peptides attached to the capsid of the viral vector. ",

author = "Tomatsu Shunji and Montano-suarez, \{Adriana M\} and Almeciga-diaz, \{Carlos J\} and Barrera Luis",

year = "2010",

month = jan,

day = "14",

language = "English",

type = "Patent",

note = "US 2010/0008979 A1; A61K9/127,A61K31/7088,A61K35/76,A61K38/02,A61K38/46,C12N7/00",

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TY - PAT

T1 - DELIVERY OF THERAPEUTIC AGENTS TO THE BONE

AU - Shunji, Tomatsu

AU - Montano-suarez, Adriana M

AU - Almeciga-diaz, Carlos J

AU - Luis, Barrera

PY - 2010/1/14

Y1 - 2010/1/14

N2 - This invention relates to compositions and methods of delivering therapeutic agents to bone. More specifically, the invention relates to endowing a large molecule vectors i.e., adeno virus, retrovirus, liposomes, micelles, natural and synthetic polymers, or combinations thereof, with the ability to target bone tissue in vivo and with improved stability in the blood, by attaching multiple copies of acid amino acid peptides. One preferred embodiment of the invention relates to endowing an adeno-associated virus (AAV) vector with the ability to target bone-tissue in vivo and improve its stability, by the addition of multiple acidic amino acid peptides attached to the capsid of the viral vector.

AB - This invention relates to compositions and methods of delivering therapeutic agents to bone. More specifically, the invention relates to endowing a large molecule vectors i.e., adeno virus, retrovirus, liposomes, micelles, natural and synthetic polymers, or combinations thereof, with the ability to target bone tissue in vivo and with improved stability in the blood, by attaching multiple copies of acid amino acid peptides. One preferred embodiment of the invention relates to endowing an adeno-associated virus (AAV) vector with the ability to target bone-tissue in vivo and improve its stability, by the addition of multiple acidic amino acid peptides attached to the capsid of the viral vector.

UR - https://www.lens.org/117-070-225-115-615

UR - https://patents.google.com/patent/US20100008979A1/en?oq=US+2010%2f0008979+A1

M3 - Invention patent

M1 - US 2010/0008979 A1

Y2 - 2009/07/03

ER -

DELIVERY OF THERAPEUTIC AGENTS TO THE BONE

Abstract

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