Deciphering the virulence factors of the opportunistic pathogen Mycobacterium colombiense

M. N. Gonzalez-Perez; M. I. Murcia; C. Parra-Lopez; J. Blom; A. Tauch

doi:10.1016/j.nmni.2016.09.007

Deciphering the virulence factors of the opportunistic pathogen Mycobacterium colombiense

M. N. Gonzalez-Perez, M. I. Murcia, C. Parra-Lopez, J. Blom, A. Tauch

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Mycobacterium avium complex (MAC) contains clinically important nontuberculous mycobacteria worldwide and is the second largest medical complex in the Mycobacterium genus after the Mycobacterium tuberculosis complex. MAC comprises several species that are closely phylogenetically related but diverse regarding their host preference, course of disease, virulence and immune response. In this study we provided immunologic and virulence-related insights into the M. colombiense genome as a model of an opportunistic pathogen in the MAC. By using bioinformatic tools we found that M. colombiense has deletions in the genes involved in p-HBA/PDIM/PGL, PLC, SL-1 and HspX production, and loss of the ESX-1 locus. This information not only sheds light on our understanding the virulence mechanisms used by opportunistic MAC pathogens but also has great potential for the designing of species-specific diagnostic tools.

Original language	English
Pages (from-to)	98-105
Number of pages	8
Journal	New Microbes and New Infections
Volume	14
DOIs	https://doi.org/10.1016/j.nmni.2016.09.007
State	Published - 01 Nov 2016
Externally published	Yes

Keywords

Genomic islands
Mycobacterium colombiense
nontuberculous mycobacteria
tuberculosis
virulence factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.nmni.2016.09.007

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title = "Deciphering the virulence factors of the opportunistic pathogen Mycobacterium colombiense",

abstract = "Mycobacterium avium complex (MAC) contains clinically important nontuberculous mycobacteria worldwide and is the second largest medical complex in the Mycobacterium genus after the Mycobacterium tuberculosis complex. MAC comprises several species that are closely phylogenetically related but diverse regarding their host preference, course of disease, virulence and immune response. In this study we provided immunologic and virulence-related insights into the M. colombiense genome as a model of an opportunistic pathogen in the MAC. By using bioinformatic tools we found that M. colombiense has deletions in the genes involved in p-HBA/PDIM/PGL, PLC, SL-1 and HspX production, and loss of the ESX-1 locus. This information not only sheds light on our understanding the virulence mechanisms used by opportunistic MAC pathogens but also has great potential for the designing of species-specific diagnostic tools.",

keywords = "Genomic islands, Mycobacterium colombiense, nontuberculous mycobacteria, tuberculosis, virulence factors",

author = "Gonzalez-Perez, {M. N.} and Murcia, {M. I.} and C. Parra-Lopez and J. Blom and A. Tauch",

note = "Publisher Copyright: {\textcopyright} 2016 The Author(s)",

year = "2016",

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doi = "10.1016/j.nmni.2016.09.007",

language = "English",

volume = "14",

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T1 - Deciphering the virulence factors of the opportunistic pathogen Mycobacterium colombiense

AU - Gonzalez-Perez, M. N.

AU - Murcia, M. I.

AU - Parra-Lopez, C.

AU - Blom, J.

AU - Tauch, A.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Mycobacterium avium complex (MAC) contains clinically important nontuberculous mycobacteria worldwide and is the second largest medical complex in the Mycobacterium genus after the Mycobacterium tuberculosis complex. MAC comprises several species that are closely phylogenetically related but diverse regarding their host preference, course of disease, virulence and immune response. In this study we provided immunologic and virulence-related insights into the M. colombiense genome as a model of an opportunistic pathogen in the MAC. By using bioinformatic tools we found that M. colombiense has deletions in the genes involved in p-HBA/PDIM/PGL, PLC, SL-1 and HspX production, and loss of the ESX-1 locus. This information not only sheds light on our understanding the virulence mechanisms used by opportunistic MAC pathogens but also has great potential for the designing of species-specific diagnostic tools.

AB - Mycobacterium avium complex (MAC) contains clinically important nontuberculous mycobacteria worldwide and is the second largest medical complex in the Mycobacterium genus after the Mycobacterium tuberculosis complex. MAC comprises several species that are closely phylogenetically related but diverse regarding their host preference, course of disease, virulence and immune response. In this study we provided immunologic and virulence-related insights into the M. colombiense genome as a model of an opportunistic pathogen in the MAC. By using bioinformatic tools we found that M. colombiense has deletions in the genes involved in p-HBA/PDIM/PGL, PLC, SL-1 and HspX production, and loss of the ESX-1 locus. This information not only sheds light on our understanding the virulence mechanisms used by opportunistic MAC pathogens but also has great potential for the designing of species-specific diagnostic tools.

KW - Genomic islands

KW - Mycobacterium colombiense

KW - nontuberculous mycobacteria

KW - tuberculosis

KW - virulence factors

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U2 - 10.1016/j.nmni.2016.09.007

DO - 10.1016/j.nmni.2016.09.007

M3 - Article

AN - SCOPUS:84994318674

SN - 2052-2975

VL - 14

SP - 98

EP - 105

JO - New Microbes and New Infections

JF - New Microbes and New Infections

ER -

Deciphering the virulence factors of the opportunistic pathogen Mycobacterium colombiense

Abstract

Keywords

UN SDGs

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