Concentrados de complejo protrombínico en el servicio de urgencias

The prothrombin complex concentrates (PCC) are compounds derived from plasma that incorporates clotting factors dependent on vitamin K. They were developed in 1950 as a source of factor IX for the treatment of hemophilia B and currently their main indication is the reversal of the effects from oral anticoagulants vitamin K antagonists type in emergency situations. Other indications outlined for the use of PCC are the following: replacement therapy for factors II and X in some congenital and acquired defects, coagulopathy associated with severe liver disease, management of perioperative bleeding complications, massive trauma in anticoagulated patients and coagulopathies by sepsis.