Chiropterans Are a Hotspot for Horizontal Transfer of DNA Transposons in Mammalia

Nicole S. Paulat; Jessica M. Storer; Diana D. Moreno-Santillán; Austin B. Osmanski; Kevin A.M. Sullivan; Jenna R. Grimshaw; Jennifer Korstian; Michaela Halsey; Carlos J. Garcia; Claudia Crookshanks; Jaquelyn Roberts; Arian F.A. Smit; Robert Hubley; Jeb Rosen; Emma C. Teeling; Sonja C. Vernes; Eugene Myers; Martin Pippel; Thomas Brown; Michael Hiller; Zoonomia Consortium; Danny Rojas; Liliana M. Dávalos; Kerstin Lindblad-To; Elinor K. Karlsson; David A. Ray

doi:10.1093/molbev/msad092

Chiropterans Are a Hotspot for Horizontal Transfer of DNA Transposons in Mammalia

Nicole S. Paulat
, Jessica M. Storer
, Diana D. Moreno-Santillán
, Austin B. Osmanski
, Kevin A.M. Sullivan
, Jenna R. Grimshaw
, Jennifer Korstian
, Michaela Halsey
, Carlos J. Garcia
, Claudia Crookshanks
, Jaquelyn Roberts
, Arian F.A. Smit
, Robert Hubley
, Jeb Rosen
, Emma C. Teeling
, Sonja C. Vernes
, Eugene Myers
, Martin Pippel
, Thomas Brown
, Michael Hiller

Zoonomia Consortium, Danny Rojas, Liliana M. Dávalos, Kerstin Lindblad-To, Elinor K. Karlsson, David A. Ray

Texas Tech University
Institute for Systems Biology
University College Dublin
Max Planck Institute for Psycholinguistics
Radboud University Nijmegen
University of St Andrews
Max Planck Institute of Molecular Cell Biology and Genetics
LOEWE Centre for Translational Biodiversity Genomics
Universidad Javeriana
Stony Brook University
Uppsala University
Broad Institute
University of Massachusetts Medical School

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Horizontal transfer of transposable elements (TEs) is an important mechanism contributing to genetic diversity and innovation. Bats (order Chiroptera) have repeatedly been shown to experience horizontal transfer of TEs at what appears to be a high rate compared with other mammals. We investigated the occurrence of horizontally transferred (HT) DNA transposons involving bats. We found over 200 putative HT elements within bats; 16 transposons were shared across distantly related mammalian clades, and 2 other elements were shared with a fish and two lizard species. Our results indicate that bats are a hotspot for horizontal transfer of DNA transposons. These events broadly coincide with the diversification of several bat clades, supporting the hypothesis that DNA transposon invasions have contributed to genetic diversification of bats.

Original language	English
Article number	msad092
Journal	Molecular biology and evolution
Volume	40
Issue number	5
DOIs	https://doi.org/10.1093/molbev/msad092
State	Published - 01 May 2023

Keywords

echidna
endogenous retrovirus
fusogenic envelope protein
monotremes
platypus

Access to Document

10.1093/molbev/msad092

Cite this

Paulat, N. S., Storer, J. M., Moreno-Santillán, D. D., Osmanski, A. B., Sullivan, K. A. M., Grimshaw, J. R., Korstian, J., Halsey, M., Garcia, C. J., Crookshanks, C., Roberts, J., Smit, A. F. A., Hubley, R., Rosen, J., Teeling, E. C., Vernes, S. C., Myers, E., Pippel, M., Brown, T., ... Ray, D. A. (2023). Chiropterans Are a Hotspot for Horizontal Transfer of DNA Transposons in Mammalia. Molecular biology and evolution, 40(5), Article msad092. https://doi.org/10.1093/molbev/msad092

@article{398f25520d3242788b02b876536dca72,

title = "Chiropterans Are a Hotspot for Horizontal Transfer of DNA Transposons in Mammalia",

abstract = "Horizontal transfer of transposable elements (TEs) is an important mechanism contributing to genetic diversity and innovation. Bats (order Chiroptera) have repeatedly been shown to experience horizontal transfer of TEs at what appears to be a high rate compared with other mammals. We investigated the occurrence of horizontally transferred (HT) DNA transposons involving bats. We found over 200 putative HT elements within bats; 16 transposons were shared across distantly related mammalian clades, and 2 other elements were shared with a fish and two lizard species. Our results indicate that bats are a hotspot for horizontal transfer of DNA transposons. These events broadly coincide with the diversification of several bat clades, supporting the hypothesis that DNA transposon invasions have contributed to genetic diversification of bats.",

keywords = "echidna, endogenous retrovirus, fusogenic envelope protein, monotremes, platypus",

author = "Paulat, \{Nicole S.\} and Storer, \{Jessica M.\} and Moreno-Santill{\'a}n, \{Diana D.\} and Osmanski, \{Austin B.\} and Sullivan, \{Kevin A.M.\} and Grimshaw, \{Jenna R.\} and Jennifer Korstian and Michaela Halsey and Garcia, \{Carlos J.\} and Claudia Crookshanks and Jaquelyn Roberts and Smit, \{Arian F.A.\} and Robert Hubley and Jeb Rosen and Teeling, \{Emma C.\} and Vernes, \{Sonja C.\} and Eugene Myers and Martin Pippel and Thomas Brown and Michael Hiller and Zoonomia Consortium and Danny Rojas and D{\'a}valos, \{Liliana M.\} and Kerstin Lindblad-To and Karlsson, \{Elinor K.\} and Ray, \{David A.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2023.",

year = "2023",

month = may,

day = "1",

doi = "10.1093/molbev/msad092",

language = "English",

volume = "40",

journal = "Molecular biology and evolution",

issn = "0737-4038",

publisher = "Oxford University Press",

number = "5",

}

Paulat, NS, Storer, JM, Moreno-Santillán, DD, Osmanski, AB, Sullivan, KAM, Grimshaw, JR, Korstian, J, Halsey, M, Garcia, CJ, Crookshanks, C, Roberts, J, Smit, AFA, Hubley, R, Rosen, J, Teeling, EC, Vernes, SC, Myers, E, Pippel, M, Brown, T, Hiller, M, Consortium, Z, Rojas, D, Dávalos, LM, Lindblad-To, K, Karlsson, EK & Ray, DA 2023, 'Chiropterans Are a Hotspot for Horizontal Transfer of DNA Transposons in Mammalia', Molecular biology and evolution, vol. 40, no. 5, msad092. https://doi.org/10.1093/molbev/msad092

TY - JOUR

T1 - Chiropterans Are a Hotspot for Horizontal Transfer of DNA Transposons in Mammalia

AU - Paulat, Nicole S.

AU - Storer, Jessica M.

AU - Moreno-Santillán, Diana D.

AU - Osmanski, Austin B.

AU - Sullivan, Kevin A.M.

AU - Grimshaw, Jenna R.

AU - Korstian, Jennifer

AU - Halsey, Michaela

AU - Garcia, Carlos J.

AU - Crookshanks, Claudia

AU - Roberts, Jaquelyn

AU - Smit, Arian F.A.

AU - Hubley, Robert

AU - Rosen, Jeb

AU - Teeling, Emma C.

AU - Vernes, Sonja C.

AU - Myers, Eugene

AU - Pippel, Martin

AU - Brown, Thomas

AU - Hiller, Michael

AU - Consortium, Zoonomia

AU - Rojas, Danny

AU - Dávalos, Liliana M.

AU - Lindblad-To, Kerstin

AU - Karlsson, Elinor K.

AU - Ray, David A.

PY - 2023/5/1

Y1 - 2023/5/1

N2 - Horizontal transfer of transposable elements (TEs) is an important mechanism contributing to genetic diversity and innovation. Bats (order Chiroptera) have repeatedly been shown to experience horizontal transfer of TEs at what appears to be a high rate compared with other mammals. We investigated the occurrence of horizontally transferred (HT) DNA transposons involving bats. We found over 200 putative HT elements within bats; 16 transposons were shared across distantly related mammalian clades, and 2 other elements were shared with a fish and two lizard species. Our results indicate that bats are a hotspot for horizontal transfer of DNA transposons. These events broadly coincide with the diversification of several bat clades, supporting the hypothesis that DNA transposon invasions have contributed to genetic diversification of bats.

AB - Horizontal transfer of transposable elements (TEs) is an important mechanism contributing to genetic diversity and innovation. Bats (order Chiroptera) have repeatedly been shown to experience horizontal transfer of TEs at what appears to be a high rate compared with other mammals. We investigated the occurrence of horizontally transferred (HT) DNA transposons involving bats. We found over 200 putative HT elements within bats; 16 transposons were shared across distantly related mammalian clades, and 2 other elements were shared with a fish and two lizard species. Our results indicate that bats are a hotspot for horizontal transfer of DNA transposons. These events broadly coincide with the diversification of several bat clades, supporting the hypothesis that DNA transposon invasions have contributed to genetic diversification of bats.

KW - echidna

KW - endogenous retrovirus

KW - fusogenic envelope protein

KW - monotremes

KW - platypus

UR - https://www.scopus.com/pages/publications/85159552469

U2 - 10.1093/molbev/msad092

DO - 10.1093/molbev/msad092

M3 - Article

C2 - 37071810

AN - SCOPUS:85159552469

SN - 0737-4038

VL - 40

JO - Molecular biology and evolution

JF - Molecular biology and evolution

IS - 5

M1 - msad092

ER -

Chiropterans Are a Hotspot for Horizontal Transfer of DNA Transposons in Mammalia

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this