Cervical cancer

Rolando Herrero; Raul Murillo

doi:10.1093/oso/9780190238667.003.0048

Cervical cancer

Rolando Herrero, Raul Murillo

International Agency for Research on Cancer

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

19 Scopus citations

Abstract

Cervical cancer is the fourth most common cancer in women worldwide, with more than 500,000 cases and 250,000 deaths per year. The disease is characterized by marked regional differences, with more than 80% of the cases and deaths occurring in developing countries. The etiology and natural history of the disease are very well studied, with persistent infection with one of thirteen human papillomavirus (HPV) types now considered to be a necessary cause. The molecular mechanisms have also been elucidated and are mediated mainly by the expression of viral oncogenes that interfere with cellular pathways. The two most common HPV types, namely HPV-16 and HPV-18, are associated with about 70% of all cases around the world. Immunologic (e.g., HIV infection), hormonal (e.g., high parity), environmental (e.g., smoking), and genetic (e.g., HLA type) cofactors determine the risk of persistence and cancer among women harboring HPV infection.

Original language	English
Title of host publication	Schottenfeld and Fraumeni Cancer Epidemiology and Prevention, Fourth Edition
Publisher	Oxford University Press
Pages	925-946
Number of pages	22
ISBN (Electronic)	9780190238667
DOIs	https://doi.org/10.1093/oso/9780190238667.003.0048
State	Published - 01 Jan 2017
Externally published	Yes

Keywords

Cervical cancer
Cervix
Etiology
HPV
Human papillomavirus
Oncogene
Risk

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/oso/9780190238667.003.0048

Cite this

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abstract = "Cervical cancer is the fourth most common cancer in women worldwide, with more than 500,000 cases and 250,000 deaths per year. The disease is characterized by marked regional differences, with more than 80\% of the cases and deaths occurring in developing countries. The etiology and natural history of the disease are very well studied, with persistent infection with one of thirteen human papillomavirus (HPV) types now considered to be a necessary cause. The molecular mechanisms have also been elucidated and are mediated mainly by the expression of viral oncogenes that interfere with cellular pathways. The two most common HPV types, namely HPV-16 and HPV-18, are associated with about 70\% of all cases around the world. Immunologic (e.g., HIV infection), hormonal (e.g., high parity), environmental (e.g., smoking), and genetic (e.g., HLA type) cofactors determine the risk of persistence and cancer among women harboring HPV infection.",

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AU - Murillo, Raul

N1 - Publisher Copyright: © Oxford University Press 2018.

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N2 - Cervical cancer is the fourth most common cancer in women worldwide, with more than 500,000 cases and 250,000 deaths per year. The disease is characterized by marked regional differences, with more than 80% of the cases and deaths occurring in developing countries. The etiology and natural history of the disease are very well studied, with persistent infection with one of thirteen human papillomavirus (HPV) types now considered to be a necessary cause. The molecular mechanisms have also been elucidated and are mediated mainly by the expression of viral oncogenes that interfere with cellular pathways. The two most common HPV types, namely HPV-16 and HPV-18, are associated with about 70% of all cases around the world. Immunologic (e.g., HIV infection), hormonal (e.g., high parity), environmental (e.g., smoking), and genetic (e.g., HLA type) cofactors determine the risk of persistence and cancer among women harboring HPV infection.

AB - Cervical cancer is the fourth most common cancer in women worldwide, with more than 500,000 cases and 250,000 deaths per year. The disease is characterized by marked regional differences, with more than 80% of the cases and deaths occurring in developing countries. The etiology and natural history of the disease are very well studied, with persistent infection with one of thirteen human papillomavirus (HPV) types now considered to be a necessary cause. The molecular mechanisms have also been elucidated and are mediated mainly by the expression of viral oncogenes that interfere with cellular pathways. The two most common HPV types, namely HPV-16 and HPV-18, are associated with about 70% of all cases around the world. Immunologic (e.g., HIV infection), hormonal (e.g., high parity), environmental (e.g., smoking), and genetic (e.g., HLA type) cofactors determine the risk of persistence and cancer among women harboring HPV infection.

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KW - Cervix

KW - Etiology

KW - HPV

KW - Human papillomavirus

KW - Oncogene

KW - Risk

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BT - Schottenfeld and Fraumeni Cancer Epidemiology and Prevention, Fourth Edition

PB - Oxford University Press

ER -

Cervical cancer

Abstract

Keywords

UN SDGs

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