CD8+ T cell response to trypanosoma cruzi antigens during chronic chagas disease

Paola Lasso; Jose Mateus; John Mario González; Adriana Cuéllar; Concepción Puerta

doi:10.1007/978-1-4939-9148-8_26

CD8⁺ T cell response to trypanosoma cruzi antigens during chronic chagas disease

Paola Lasso
, Jose Mateus
, John Mario González
, Adriana Cuéllar
, Concepción Puerta

Department of Microbiology

Universidad Javeriana
Universidad de los Andes Colombia

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Scopus citations

Abstract

Flow cytometry is a valuable technique in cellular immunology that allows evaluating effective parameters of the immune response associated with CD8⁺ T cells. During Chagas disease, infection caused by Trypanosoma cruzi parasite, similar to other intracellular infectious agents, antigen-specific CD8⁺ T cells are essential for controlling the infection. However, CD8⁺ T cell response is only partially effective in some chronic Chagas disease patients. Thus, characterization and phenotyping of T. cruzi-specific CD8⁺ T cells are of great importance during chronic Chagas disease.

Original language	English
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	349-361
Number of pages	13
DOIs	https://doi.org/10.1007/978-1-4939-9148-8_26
State	Published - 2019

Publication series

Name	Methods in Molecular Biology
Volume	1955
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CD8 T cells
Chagas disease
Cytometry
Inhibitory receptors
Phenotype
Polyfunctionality

Access to Document

10.1007/978-1-4939-9148-8_26

Cite this

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title = "CD8+ T cell response to trypanosoma cruzi antigens during chronic chagas disease",

abstract = "Flow cytometry is a valuable technique in cellular immunology that allows evaluating effective parameters of the immune response associated with CD8+ T cells. During Chagas disease, infection caused by Trypanosoma cruzi parasite, similar to other intracellular infectious agents, antigen-specific CD8+ T cells are essential for controlling the infection. However, CD8+ T cell response is only partially effective in some chronic Chagas disease patients. Thus, characterization and phenotyping of T. cruzi-specific CD8+ T cells are of great importance during chronic Chagas disease.",

keywords = "CD8 T cells, Chagas disease, Cytometry, Inhibitory receptors, Phenotype, Polyfunctionality",

author = "Paola Lasso and Jose Mateus and Gonz{\'a}lez, \{John Mario\} and Adriana Cu{\'e}llar and Concepci{\'o}n Puerta",

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AU - Lasso, Paola

AU - Mateus, Jose

AU - González, John Mario

AU - Cuéllar, Adriana

AU - Puerta, Concepción

N1 - Publisher Copyright: © Springer Science+Business Media, LLC, part of Springer Nature 2019.

PY - 2019

Y1 - 2019

N2 - Flow cytometry is a valuable technique in cellular immunology that allows evaluating effective parameters of the immune response associated with CD8+ T cells. During Chagas disease, infection caused by Trypanosoma cruzi parasite, similar to other intracellular infectious agents, antigen-specific CD8+ T cells are essential for controlling the infection. However, CD8+ T cell response is only partially effective in some chronic Chagas disease patients. Thus, characterization and phenotyping of T. cruzi-specific CD8+ T cells are of great importance during chronic Chagas disease.

AB - Flow cytometry is a valuable technique in cellular immunology that allows evaluating effective parameters of the immune response associated with CD8+ T cells. During Chagas disease, infection caused by Trypanosoma cruzi parasite, similar to other intracellular infectious agents, antigen-specific CD8+ T cells are essential for controlling the infection. However, CD8+ T cell response is only partially effective in some chronic Chagas disease patients. Thus, characterization and phenotyping of T. cruzi-specific CD8+ T cells are of great importance during chronic Chagas disease.

KW - CD8 T cells

KW - Chagas disease

KW - Cytometry

KW - Inhibitory receptors

KW - Phenotype

KW - Polyfunctionality

UR - https://www.scopus.com/pages/publications/85062854763

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AN - SCOPUS:85062854763

T3 - Methods in Molecular Biology

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BT - Methods in Molecular Biology

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