CD8+ T cell response to trypanosoma cruzi antigens during chronic chagas disease

Paola Lasso, Jose Mateus, John Mario González, Adriana Cuéllar, Concepción Puerta

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations

Abstract

Flow cytometry is a valuable technique in cellular immunology that allows evaluating effective parameters of the immune response associated with CD8+ T cells. During Chagas disease, infection caused by Trypanosoma cruzi parasite, similar to other intracellular infectious agents, antigen-specific CD8+ T cells are essential for controlling the infection. However, CD8+ T cell response is only partially effective in some chronic Chagas disease patients. Thus, characterization and phenotyping of T. cruzi-specific CD8+ T cells are of great importance during chronic Chagas disease.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages349-361
Number of pages13
DOIs
StatePublished - 2019

Publication series

NameMethods in Molecular Biology
Volume1955
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • CD8 T cells
  • Chagas disease
  • Cytometry
  • Inhibitory receptors
  • Phenotype
  • Polyfunctionality

Fingerprint

Dive into the research topics of 'CD8+ T cell response to trypanosoma cruzi antigens during chronic chagas disease'. Together they form a unique fingerprint.

Cite this