Caracterización genómica de un grupo de individuos con Deterioro Cognitivo Leve (DCL) en población del Atlántico, Colombia

Mild Cognitive Impairment (MCI) is an early stage of Alzheimer’s disease (AD), characterized by a decline in cognition without reaching the threshold for dementia. Genetic factors influence its development, and several variants associated with its progression have been identified, with the APOE-ϵ4 allele standing out as a key marker in the transition from MCI to AD.
The prevalence of MCI ranges from 5.0% to 36.7% worldwide, while in Colombia, it affects 17.5% of the population, with the highest incidence in the Atlántico region. Despite the availability of current diagnostic tools, a multi-omics approach is necessary for a deeper understanding of the disease.
Advances in next-generation sequencing (NGS) enable the identification of key genetic factors in neurodegenerative diseases, facilitating the development of preventive and therapeutic strategies. In this context, the opportunity arises to conduct an association study and genomic characterization of MCI patients and controls from the Atlántico region, Colombia, aiming to gain deeper insights into the genetic mechanisms involved in this population, which exhibits a high prevalence of neurodegenerative diseases.