Canine mammary carcinoma: An update

Oscar Hernán Rodríguez-Bejarano; Lucía Botero; Giovanni Vargas Hernández; Carlos Parra-Lopez; Manuel Alfonso Patarroyo

doi:10.1016/j.tvjl.2026.106668

Canine mammary carcinoma: An update

Oscar Hernán Rodríguez-Bejarano
, Lucía Botero
, Giovanni Vargas Hernández
, Carlos Parra-Lopez
, Manuel Alfonso Patarroyo

Universidad de Ciencias Aplicadas y Ambientales
Fundación Instituto de Inmunología de Colombia
Universidad Nacional de Colombia
Fundación para la Investigación Traslacional Manuel Elkin Patarroyo (FITMEP)

Research output: Contribution to journal › Review article › peer-review

Abstract

Canine mammary carcinoma (CMC) is the most frequently diagnosed tumour in unspayed canines and leads to one of the main causes of their deaths, thereby making it a major problem for veterinary medicine. Such neoplasia appears spontaneously and, due to its biological and clinical similarity with human breast cancer (HBC), it has been considered an excellent animal biomodel for studying this type of cancer. This review addresses CMC's main characteristics, including clinical-diagnostic approach, histopathological and clinicopathological aspects, epidemiological features, carcinogenesis, metabolic reprogramming, therapeutic tools, related biomarkers and prognostic and predictive factors.

Original language	English
Article number	106668
Journal	Veterinary Journal
Volume	317
DOIs	https://doi.org/10.1016/j.tvjl.2026.106668
State	Published - Jun 2026
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biomarkers
Canine biomodel
Canine mammary cancer
Carcinogenesis
Classification
Diagnosis
Translational application
Treatment

Access to Document

10.1016/j.tvjl.2026.106668

Cite this

@article{faa96a5942a34380ad3960731732a296,

title = "Canine mammary carcinoma: An update",

abstract = "Canine mammary carcinoma (CMC) is the most frequently diagnosed tumour in unspayed canines and leads to one of the main causes of their deaths, thereby making it a major problem for veterinary medicine. Such neoplasia appears spontaneously and, due to its biological and clinical similarity with human breast cancer (HBC), it has been considered an excellent animal biomodel for studying this type of cancer. This review addresses CMC's main characteristics, including clinical-diagnostic approach, histopathological and clinicopathological aspects, epidemiological features, carcinogenesis, metabolic reprogramming, therapeutic tools, related biomarkers and prognostic and predictive factors.",

keywords = "Biomarkers, Canine biomodel, Canine mammary cancer, Carcinogenesis, Classification, Diagnosis, Translational application, Treatment",

author = "Rodr{\'i}guez-Bejarano, \{Oscar Hern{\'a}n\} and Luc{\'i}a Botero and Hern{\'a}ndez, \{Giovanni Vargas\} and Carlos Parra-Lopez and Patarroyo, \{Manuel Alfonso\}",

note = "Publisher Copyright: {\textcopyright} 2026 The Authors",

year = "2026",

month = jun,

doi = "10.1016/j.tvjl.2026.106668",

language = "English",

volume = "317",

journal = "Veterinary Journal",

issn = "1090-0233",

publisher = "Bailliere Tindall Ltd",

}

TY - JOUR

T1 - Canine mammary carcinoma

T2 - An update

AU - Rodríguez-Bejarano, Oscar Hernán

AU - Botero, Lucía

AU - Hernández, Giovanni Vargas

AU - Parra-Lopez, Carlos

AU - Patarroyo, Manuel Alfonso

PY - 2026/6

Y1 - 2026/6

N2 - Canine mammary carcinoma (CMC) is the most frequently diagnosed tumour in unspayed canines and leads to one of the main causes of their deaths, thereby making it a major problem for veterinary medicine. Such neoplasia appears spontaneously and, due to its biological and clinical similarity with human breast cancer (HBC), it has been considered an excellent animal biomodel for studying this type of cancer. This review addresses CMC's main characteristics, including clinical-diagnostic approach, histopathological and clinicopathological aspects, epidemiological features, carcinogenesis, metabolic reprogramming, therapeutic tools, related biomarkers and prognostic and predictive factors.

AB - Canine mammary carcinoma (CMC) is the most frequently diagnosed tumour in unspayed canines and leads to one of the main causes of their deaths, thereby making it a major problem for veterinary medicine. Such neoplasia appears spontaneously and, due to its biological and clinical similarity with human breast cancer (HBC), it has been considered an excellent animal biomodel for studying this type of cancer. This review addresses CMC's main characteristics, including clinical-diagnostic approach, histopathological and clinicopathological aspects, epidemiological features, carcinogenesis, metabolic reprogramming, therapeutic tools, related biomarkers and prognostic and predictive factors.

KW - Biomarkers

KW - Canine biomodel

KW - Canine mammary cancer

KW - Carcinogenesis

KW - Classification

KW - Diagnosis

KW - Translational application

KW - Treatment

UR - https://www.scopus.com/pages/publications/105036005851

U2 - 10.1016/j.tvjl.2026.106668

DO - 10.1016/j.tvjl.2026.106668

M3 - Review article

C2 - 41990944

AN - SCOPUS:105036005851

SN - 1090-0233

VL - 317

JO - Veterinary Journal

JF - Veterinary Journal

M1 - 106668

ER -

Canine mammary carcinoma: An update

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this