Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants

Shuai Li; Valentina Silvestri; Goska Leslie; Timothy R. Rebbeck; Susan L. Neuhausen; John L. Hopper; Henriette Roed Nielsen; Andrew Lee; Xin Yang; Lesley Mcguffog; Michael T. Parsons; Irene L. Andrulis; Norbert Arnold; Muriel Belotti; Åke Borg; Bruno Buecher; Saundra S. Buys; Sandrine M. Caputo; Wendy K. Chung; Chrystelle Colas; Sarah V. Colonna; Jackie Cook; Mary B. Daly; Miguel De La Hoya; Antoine De Pauw; Hélène Delhomelle; Jacqueline Eason; Christoph Engel; D. Gareth Evans; Ulrike Faust; Tanja N. Fehm; Florentia Fostira; George Fountzilas; Megan Frone; Vanesa Garcia-Barberan; Pilar Garre; Marion Gauthier-Villars; Andrea Gehrig; Gord Glendon; David E. Goldgar; Lisa Golmard; Mark H. Greene; Eric Hahnen; Ute Hamann; Helen Hanson; Tiara Hassan; Julia Hentschel; Judit Horvath; Louise Izatt; Ramunas Janavicius; Yue Jiao; Esther M. John; Beth Y. Karlan; Sung Won Kim; Irene Konstantopoulou; Ava Kwong; Anthony Laugé; Jong Won Lee; Fabienne Lesueur; Noura Mebirouk; Alfons Meindl; Emmanuelle Mouret-Fourme; Hannah Musgrave; Joanne Ngeow Yuen Yie; Dieter Niederacher; Sue K. Park; Inge Sokilde Pedersen; Juliane Ramser; Susan J. Ramus; Johanna Rantala; Muhammad U. Rashid; Florian Reichl; Julia Ritter; Andreas Rump; Marta Santamariña; Claire Saule; Gunnar Schmidt; Rita K. Schmutzler; Leigha Senter; Saba Shariff; Christian F. Singer; Melissa C. Southey; Dominique Stoppa-Lyonnet; Christian Sutter; Yen Tan; Soo Hwang Teo; Mary Beth Terry; Mads Thomassen; Marc Tischkowitz; Amanda E. Toland; Diana Torres; Ana Vega; Sebastian A. Wagner; Shan Wang-Gohrke; Barbara Wappenschmidt; Bernhard H.F. Weber; Drakoulis Yannoukakos; Amanda B. Spurdle; Douglas F. Easton; Georgia Chenevix-Trench; Laura Ottini; Antonis C. Antoniou

doi:10.1200/JCO.21.02112

Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants

Shuai Li
, Valentina Silvestri
, Goska Leslie
, Timothy R. Rebbeck
, Susan L. Neuhausen
, John L. Hopper
, Henriette Roed Nielsen
, Andrew Lee
, Xin Yang
, Lesley Mcguffog
, Michael T. Parsons
, Irene L. Andrulis
, Norbert Arnold
, Muriel Belotti
, Åke Borg
, Bruno Buecher
, Saundra S. Buys
, Sandrine M. Caputo
, Wendy K. Chung
, Chrystelle Colas

Sarah V. Colonna, Jackie Cook, Mary B. Daly, Miguel De La Hoya, Antoine De Pauw, Hélène Delhomelle, Jacqueline Eason, Christoph Engel, D. Gareth Evans, Ulrike Faust, Tanja N. Fehm, Florentia Fostira, George Fountzilas, Megan Frone, Vanesa Garcia-Barberan, Pilar Garre, Marion Gauthier-Villars, Andrea Gehrig, Gord Glendon, David E. Goldgar, Lisa Golmard, Mark H. Greene, Eric Hahnen, Ute Hamann, Helen Hanson, Tiara Hassan, Julia Hentschel, Judit Horvath, Louise Izatt, Ramunas Janavicius, Yue Jiao, Esther M. John, Beth Y. Karlan, Sung Won Kim, Irene Konstantopoulou, Ava Kwong, Anthony Laugé, Jong Won Lee, Fabienne Lesueur, Noura Mebirouk, Alfons Meindl, Emmanuelle Mouret-Fourme, Hannah Musgrave, Joanne Ngeow Yuen Yie, Dieter Niederacher, Sue K. Park, Inge Sokilde Pedersen, Juliane Ramser, Susan J. Ramus, Johanna Rantala, Muhammad U. Rashid, Florian Reichl, Julia Ritter, Andreas Rump, Marta Santamariña, Claire Saule, Gunnar Schmidt, Rita K. Schmutzler, Leigha Senter, Saba Shariff, Christian F. Singer, Melissa C. Southey, Dominique Stoppa-Lyonnet, Christian Sutter, Yen Tan, Soo Hwang Teo, Mary Beth Terry, Mads Thomassen, Marc Tischkowitz, Amanda E. Toland, Diana Torres, Ana Vega, Sebastian A. Wagner, Shan Wang-Gohrke, Barbara Wappenschmidt, Bernhard H.F. Weber, Drakoulis Yannoukakos, Amanda B. Spurdle, Douglas F. Easton, Georgia Chenevix-Trench, Laura Ottini, Antonis C. Antoniou

Institute of Human Genetics

Melbourne School of Population and Global Health
Sapienza University of Rome
Department of Public Health and Primary Care
Harvard T.H. Chan School of Public Health
Dana-Farber Cancer Institute
Beckman Research Institute of City of Hope
Odense University Hospital
QIMR Berghofer Medical Research Institute
Mount Sinai Hospital of University of Toronto
University of Toronto
University Hospital of Schleswig-Holstein
Institut Curie
PSL Research University CRIOBE USR3278 EPHE-CNRS-UPVD BP1013
Clinical Epidemiology Unit
University of Utah School of Medicine
Columbia University
Sheffield Children's NHS Foundation Trust
Fox Chase Cancer Center
Hospital Clinico San Carlos
Nottingham University Hospitals NHS Trust
Leipzig University
University of Manchester
Manchester University NHS Foundation Trust
University of Tübingen
University Hospital Düsseldorf
Demokritos National Centre for Scientific Research
Aristotle University of Thessaloniki
German Oncology Center
National Cancer Institute (NCI)
University of Würzburg
Huntsman Cancer Institute
University of Cologne
German Cancer Research Center
University of London
Cancer Research Malaysia
University of Münster
Guy's and St Thomas' NHS Foundation Trust
Vilnius University
State Research Institute Centre for Innovative Medicine
PSL Research University
Mines ParisTech
Stanford University School of Medicine
University of California at Los Angeles
Daerim St. Mary's Hospital
Hong Kong Hereditary Breast Cancer Family Registry
The University of Hong Kong
Hong Kong Sanatorium & Hospital
University of Ulsan
Ludwig Maximilians University
Leeds Teaching Hospitals NHS Trust
National Cancer Centre Singapore
Nanyang Technological University
Seoul National University
Seoul National University Cancer Research Institute
Aalborg University
Klinikum Rechts der Isar
University of New South Wales
Karolinska Institutet
Shaukat Khanum Memorial Cancer Hospital and Research Centre
Medical University of Vienna
Charité Universitätsmedizin
University Hospital Carl Gustav Carus
Centre for Biomedical Research on Rare Diseases (CIBERER)
Fundación Pública Galega Medicina Xenómica
University of Santiago de Compostela
Hannover Medical School
Ohio State University
Birmingham Women's and Children's NHS Foundation Trust
Monash University
University of Melbourne
Cancer Council Victoria
INSERM U830
Université Paris Descartes
Heidelberg University Hospital
University of Malaya
Mailman School of Public Health
McGill University
University of Cambridge
Goethe University Frankfurt
University Hospital Ulm
University of Regensburg
University Hospital Regensburg

Research output: Contribution to journal › Article › peer-review

255 Scopus citations

Abstract

Purpose: To provide precise age-specific risk estimates of cancers other than female breast and ovarian cancers associated with pathogenic variants (PVs) in BRCA1 and BRCA2 for effective cancer risk management. Methods: We used data from 3,184 BRCA1 and 2,157 BRCA2 families in the Consortium of Investigators of Modifiers of BRCA1/2 to estimate age-specific relative (RR) and absolute risks for 22 first primary cancer types adjusting for family ascertainment. Results: BRCA1 PVs were associated with risks of male breast (RR = 4.30; 95% CI, 1.09 to 16.96), pancreatic (RR = 2.36; 95% CI, 1.51 to 3.68), and stomach (RR = 2.17; 95% CI, 1.25 to 3.77) cancers. Associations with colorectal and gallbladder cancers were also suggested. BRCA2 PVs were associated with risks of male breast (RR = 44.0; 95% CI, 21.3 to 90.9), stomach (RR = 3.69; 95% CI, 2.40 to 5.67), pancreatic (RR = 3.34; 95% CI, 2.21 to 5.06), and prostate (RR = 2.22; 95% CI, 1.63 to 3.03) cancers. The stomach cancer RR was higher for females than males (6.89 v 2.76; P =.04). The absolute risks to age 80 years ranged from 0.4% for male breast cancer to approximately 2.5% for pancreatic cancer for BRCA1 carriers and from approximately 2.5% for pancreatic cancer to 27% for prostate cancer for BRCA2 carriers. Conclusion: In addition to female breast and ovarian cancers, BRCA1 and BRCA2 PVs are associated with increased risks of male breast, pancreatic, stomach, and prostate (only BRCA2 PVs) cancers, but not with the risks of other previously suggested cancers. The estimated age-specific risks will refine cancer risk management in men and women with BRCA1/2 PVs.

Original language	English
Pages (from-to)	1529-1541
Number of pages	13
Journal	Journal of Clinical Oncology
Volume	40
Issue number	14
DOIs	https://doi.org/10.1200/JCO.21.02112
State	Published - 10 May 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1200/JCO.21.02112

Cite this

Li, S., Silvestri, V., Leslie, G., Rebbeck, T. R., Neuhausen, S. L., Hopper, J. L., Nielsen, H. R., Lee, A., Yang, X., Mcguffog, L., Parsons, M. T., Andrulis, I. L., Arnold, N., Belotti, M., Borg, Å., Buecher, B., Buys, S. S., Caputo, S. M., Chung, W. K., ... Antoniou, A. C. (2022). Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants. Journal of Clinical Oncology, 40(14), 1529-1541. https://doi.org/10.1200/JCO.21.02112

@article{5cc17973892d41c7980010a60fa71008,

title = "Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants",

abstract = "Purpose: To provide precise age-specific risk estimates of cancers other than female breast and ovarian cancers associated with pathogenic variants (PVs) in BRCA1 and BRCA2 for effective cancer risk management. Methods: We used data from 3,184 BRCA1 and 2,157 BRCA2 families in the Consortium of Investigators of Modifiers of BRCA1/2 to estimate age-specific relative (RR) and absolute risks for 22 first primary cancer types adjusting for family ascertainment. Results: BRCA1 PVs were associated with risks of male breast (RR = 4.30; 95\% CI, 1.09 to 16.96), pancreatic (RR = 2.36; 95\% CI, 1.51 to 3.68), and stomach (RR = 2.17; 95\% CI, 1.25 to 3.77) cancers. Associations with colorectal and gallbladder cancers were also suggested. BRCA2 PVs were associated with risks of male breast (RR = 44.0; 95\% CI, 21.3 to 90.9), stomach (RR = 3.69; 95\% CI, 2.40 to 5.67), pancreatic (RR = 3.34; 95\% CI, 2.21 to 5.06), and prostate (RR = 2.22; 95\% CI, 1.63 to 3.03) cancers. The stomach cancer RR was higher for females than males (6.89 v 2.76; P =.04). The absolute risks to age 80 years ranged from 0.4\% for male breast cancer to approximately 2.5\% for pancreatic cancer for BRCA1 carriers and from approximately 2.5\% for pancreatic cancer to 27\% for prostate cancer for BRCA2 carriers. Conclusion: In addition to female breast and ovarian cancers, BRCA1 and BRCA2 PVs are associated with increased risks of male breast, pancreatic, stomach, and prostate (only BRCA2 PVs) cancers, but not with the risks of other previously suggested cancers. The estimated age-specific risks will refine cancer risk management in men and women with BRCA1/2 PVs.",

author = "Shuai Li and Valentina Silvestri and Goska Leslie and Rebbeck, \{Timothy R.\} and Neuhausen, \{Susan L.\} and Hopper, \{John L.\} and Nielsen, \{Henriette Roed\} and Andrew Lee and Xin Yang and Lesley Mcguffog and Parsons, \{Michael T.\} and Andrulis, \{Irene L.\} and Norbert Arnold and Muriel Belotti and {\AA}ke Borg and Bruno Buecher and Buys, \{Saundra S.\} and Caputo, \{Sandrine M.\} and Chung, \{Wendy K.\} and Chrystelle Colas and Colonna, \{Sarah V.\} and Jackie Cook and Daly, \{Mary B.\} and \{De La Hoya\}, Miguel and \{De Pauw\}, Antoine and H{\'e}l{\`e}ne Delhomelle and Jacqueline Eason and Christoph Engel and Evans, \{D. Gareth\} and Ulrike Faust and Fehm, \{Tanja N.\} and Florentia Fostira and George Fountzilas and Megan Frone and Vanesa Garcia-Barberan and Pilar Garre and Marion Gauthier-Villars and Andrea Gehrig and Gord Glendon and Goldgar, \{David E.\} and Lisa Golmard and Greene, \{Mark H.\} and Eric Hahnen and Ute Hamann and Helen Hanson and Tiara Hassan and Julia Hentschel and Judit Horvath and Louise Izatt and Ramunas Janavicius and Yue Jiao and John, \{Esther M.\} and Karlan, \{Beth Y.\} and Kim, \{Sung Won\} and Irene Konstantopoulou and Ava Kwong and Anthony Laug{\'e} and Lee, \{Jong Won\} and Fabienne Lesueur and Noura Mebirouk and Alfons Meindl and Emmanuelle Mouret-Fourme and Hannah Musgrave and \{Ngeow Yuen Yie\}, Joanne and Dieter Niederacher and Park, \{Sue K.\} and Pedersen, \{Inge Sokilde\} and Juliane Ramser and Ramus, \{Susan J.\} and Johanna Rantala and Rashid, \{Muhammad U.\} and Florian Reichl and Julia Ritter and Andreas Rump and Marta Santamari{\~n}a and Claire Saule and Gunnar Schmidt and Schmutzler, \{Rita K.\} and Leigha Senter and Saba Shariff and Singer, \{Christian F.\} and Southey, \{Melissa C.\} and Dominique Stoppa-Lyonnet and Christian Sutter and Yen Tan and Teo, \{Soo Hwang\} and Terry, \{Mary Beth\} and Mads Thomassen and Marc Tischkowitz and Toland, \{Amanda E.\} and Diana Torres and Ana Vega and Wagner, \{Sebastian A.\} and Shan Wang-Gohrke and Barbara Wappenschmidt and Weber, \{Bernhard H.F.\} and Drakoulis Yannoukakos and Spurdle, \{Amanda B.\} and Easton, \{Douglas F.\} and Georgia Chenevix-Trench and Laura Ottini and Antoniou, \{Antonis C.\}",

note = "Publisher Copyright: {\textcopyright} American Society of Clinical Oncology.",

year = "2022",

month = may,

day = "10",

doi = "10.1200/JCO.21.02112",

language = "English",

volume = "40",

pages = "1529--1541",

journal = "Journal of Clinical Oncology",

issn = "0732-183X",

publisher = "Lippincott Williams and Wilkins",

number = "14",

}

Li, S, Silvestri, V, Leslie, G, Rebbeck, TR, Neuhausen, SL, Hopper, JL, Nielsen, HR, Lee, A, Yang, X, Mcguffog, L, Parsons, MT, Andrulis, IL, Arnold, N, Belotti, M, Borg, Å, Buecher, B, Buys, SS, Caputo, SM, Chung, WK, Colas, C, Colonna, SV, Cook, J, Daly, MB, De La Hoya, M, De Pauw, A, Delhomelle, H, Eason, J, Engel, C, Evans, DG, Faust, U, Fehm, TN, Fostira, F, Fountzilas, G, Frone, M, Garcia-Barberan, V, Garre, P, Gauthier-Villars, M, Gehrig, A, Glendon, G, Goldgar, DE, Golmard, L, Greene, MH, Hahnen, E, Hamann, U, Hanson, H, Hassan, T, Hentschel, J, Horvath, J, Izatt, L, Janavicius, R, Jiao, Y, John, EM, Karlan, BY, Kim, SW, Konstantopoulou, I, Kwong, A, Laugé, A, Lee, JW, Lesueur, F, Mebirouk, N, Meindl, A, Mouret-Fourme, E, Musgrave, H, Ngeow Yuen Yie, J, Niederacher, D, Park, SK, Pedersen, IS, Ramser, J, Ramus, SJ, Rantala, J, Rashid, MU, Reichl, F, Ritter, J, Rump, A, Santamariña, M, Saule, C, Schmidt, G, Schmutzler, RK, Senter, L, Shariff, S, Singer, CF, Southey, MC, Stoppa-Lyonnet, D, Sutter, C, Tan, Y, Teo, SH, Terry, MB, Thomassen, M, Tischkowitz, M, Toland, AE, Torres, D, Vega, A, Wagner, SA, Wang-Gohrke, S, Wappenschmidt, B, Weber, BHF, Yannoukakos, D, Spurdle, AB, Easton, DF, Chenevix-Trench, G, Ottini, L & Antoniou, AC 2022, 'Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants', Journal of Clinical Oncology, vol. 40, no. 14, pp. 1529-1541. https://doi.org/10.1200/JCO.21.02112

TY - JOUR

T1 - Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants

AU - Li, Shuai

AU - Silvestri, Valentina

AU - Leslie, Goska

AU - Rebbeck, Timothy R.

AU - Neuhausen, Susan L.

AU - Hopper, John L.

AU - Nielsen, Henriette Roed

AU - Lee, Andrew

AU - Yang, Xin

AU - Mcguffog, Lesley

AU - Parsons, Michael T.

AU - Andrulis, Irene L.

AU - Arnold, Norbert

AU - Belotti, Muriel

AU - Borg, Åke

AU - Buecher, Bruno

AU - Buys, Saundra S.

AU - Caputo, Sandrine M.

AU - Chung, Wendy K.

AU - Colas, Chrystelle

AU - Colonna, Sarah V.

AU - Cook, Jackie

AU - Daly, Mary B.

AU - De La Hoya, Miguel

AU - De Pauw, Antoine

AU - Delhomelle, Hélène

AU - Eason, Jacqueline

AU - Engel, Christoph

AU - Evans, D. Gareth

AU - Faust, Ulrike

AU - Fehm, Tanja N.

AU - Fostira, Florentia

AU - Fountzilas, George

AU - Frone, Megan

AU - Garcia-Barberan, Vanesa

AU - Garre, Pilar

AU - Gauthier-Villars, Marion

AU - Gehrig, Andrea

AU - Glendon, Gord

AU - Goldgar, David E.

AU - Golmard, Lisa

AU - Greene, Mark H.

AU - Hahnen, Eric

AU - Hamann, Ute

AU - Hanson, Helen

AU - Hassan, Tiara

AU - Hentschel, Julia

AU - Horvath, Judit

AU - Izatt, Louise

AU - Janavicius, Ramunas

AU - Jiao, Yue

AU - John, Esther M.

AU - Karlan, Beth Y.

AU - Kim, Sung Won

AU - Konstantopoulou, Irene

AU - Kwong, Ava

AU - Laugé, Anthony

AU - Lee, Jong Won

AU - Lesueur, Fabienne

AU - Mebirouk, Noura

AU - Meindl, Alfons

AU - Mouret-Fourme, Emmanuelle

AU - Musgrave, Hannah

AU - Ngeow Yuen Yie, Joanne

AU - Niederacher, Dieter

AU - Park, Sue K.

AU - Pedersen, Inge Sokilde

AU - Ramser, Juliane

AU - Ramus, Susan J.

AU - Rantala, Johanna

AU - Rashid, Muhammad U.

AU - Reichl, Florian

AU - Ritter, Julia

AU - Rump, Andreas

AU - Santamariña, Marta

AU - Saule, Claire

AU - Schmidt, Gunnar

AU - Schmutzler, Rita K.

AU - Senter, Leigha

AU - Shariff, Saba

AU - Singer, Christian F.

AU - Southey, Melissa C.

AU - Stoppa-Lyonnet, Dominique

AU - Sutter, Christian

AU - Tan, Yen

AU - Teo, Soo Hwang

AU - Terry, Mary Beth

AU - Thomassen, Mads

AU - Tischkowitz, Marc

AU - Toland, Amanda E.

AU - Torres, Diana

AU - Vega, Ana

AU - Wagner, Sebastian A.

AU - Wang-Gohrke, Shan

AU - Wappenschmidt, Barbara

AU - Weber, Bernhard H.F.

AU - Yannoukakos, Drakoulis

AU - Spurdle, Amanda B.

AU - Easton, Douglas F.

AU - Chenevix-Trench, Georgia

AU - Ottini, Laura

AU - Antoniou, Antonis C.

PY - 2022/5/10

Y1 - 2022/5/10

N2 - Purpose: To provide precise age-specific risk estimates of cancers other than female breast and ovarian cancers associated with pathogenic variants (PVs) in BRCA1 and BRCA2 for effective cancer risk management. Methods: We used data from 3,184 BRCA1 and 2,157 BRCA2 families in the Consortium of Investigators of Modifiers of BRCA1/2 to estimate age-specific relative (RR) and absolute risks for 22 first primary cancer types adjusting for family ascertainment. Results: BRCA1 PVs were associated with risks of male breast (RR = 4.30; 95% CI, 1.09 to 16.96), pancreatic (RR = 2.36; 95% CI, 1.51 to 3.68), and stomach (RR = 2.17; 95% CI, 1.25 to 3.77) cancers. Associations with colorectal and gallbladder cancers were also suggested. BRCA2 PVs were associated with risks of male breast (RR = 44.0; 95% CI, 21.3 to 90.9), stomach (RR = 3.69; 95% CI, 2.40 to 5.67), pancreatic (RR = 3.34; 95% CI, 2.21 to 5.06), and prostate (RR = 2.22; 95% CI, 1.63 to 3.03) cancers. The stomach cancer RR was higher for females than males (6.89 v 2.76; P =.04). The absolute risks to age 80 years ranged from 0.4% for male breast cancer to approximately 2.5% for pancreatic cancer for BRCA1 carriers and from approximately 2.5% for pancreatic cancer to 27% for prostate cancer for BRCA2 carriers. Conclusion: In addition to female breast and ovarian cancers, BRCA1 and BRCA2 PVs are associated with increased risks of male breast, pancreatic, stomach, and prostate (only BRCA2 PVs) cancers, but not with the risks of other previously suggested cancers. The estimated age-specific risks will refine cancer risk management in men and women with BRCA1/2 PVs.

AB - Purpose: To provide precise age-specific risk estimates of cancers other than female breast and ovarian cancers associated with pathogenic variants (PVs) in BRCA1 and BRCA2 for effective cancer risk management. Methods: We used data from 3,184 BRCA1 and 2,157 BRCA2 families in the Consortium of Investigators of Modifiers of BRCA1/2 to estimate age-specific relative (RR) and absolute risks for 22 first primary cancer types adjusting for family ascertainment. Results: BRCA1 PVs were associated with risks of male breast (RR = 4.30; 95% CI, 1.09 to 16.96), pancreatic (RR = 2.36; 95% CI, 1.51 to 3.68), and stomach (RR = 2.17; 95% CI, 1.25 to 3.77) cancers. Associations with colorectal and gallbladder cancers were also suggested. BRCA2 PVs were associated with risks of male breast (RR = 44.0; 95% CI, 21.3 to 90.9), stomach (RR = 3.69; 95% CI, 2.40 to 5.67), pancreatic (RR = 3.34; 95% CI, 2.21 to 5.06), and prostate (RR = 2.22; 95% CI, 1.63 to 3.03) cancers. The stomach cancer RR was higher for females than males (6.89 v 2.76; P =.04). The absolute risks to age 80 years ranged from 0.4% for male breast cancer to approximately 2.5% for pancreatic cancer for BRCA1 carriers and from approximately 2.5% for pancreatic cancer to 27% for prostate cancer for BRCA2 carriers. Conclusion: In addition to female breast and ovarian cancers, BRCA1 and BRCA2 PVs are associated with increased risks of male breast, pancreatic, stomach, and prostate (only BRCA2 PVs) cancers, but not with the risks of other previously suggested cancers. The estimated age-specific risks will refine cancer risk management in men and women with BRCA1/2 PVs.

UR - https://www.scopus.com/pages/publications/85128181757

U2 - 10.1200/JCO.21.02112

DO - 10.1200/JCO.21.02112

M3 - Article

C2 - 35077220

AN - SCOPUS:85128181757

SN - 0732-183X

VL - 40

SP - 1529

EP - 1541

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

IS - 14

ER -

Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this