Associated factors for mortality in a COVID-19 colombian cohort: is the third wave relevant when Mu variant was predominant epidemiologically?

Carlos Alvarez-Moreno; Sandra Liliana Valderrama-Beltran; Ronaldo Silva; Ilich Herbert De La Hoz Siegler; Fabio Andrés Varón Vega; Samuel Martínez-Vernaza; Tatiana Ordoñez Blanco; Mónica Padilla; María Lucía Mesa-Rubio; Laura Carmenza Castañeda Pascagaza; José Antonio Rojas; Juan Sebastián Bravo Ojeda; Jaime Villa; Julio Alberto Chacón Sarmiento; Nancy Yomayusa; Sandra Patiño; Katherine Gómez-Nieto; Viviana Lorena Martínez Pinzón; Angélica María Ramírez Cogollo; Carlos Toloza; Melissa Diaz-Puentes; Alejandra Cañas-Arboleda; Margarita Manrique-Andrade; Roberto Tarud Ayub; María José López Mora; María Julieta Pachón Espinosa; Jorge Alberto Cortés; Laura Catalina Sánchez; Kelly Rocío Chacón Acevedo; Paola Rengifo; Ginna Tambini; Silvia Bertagnolio; Janet Diaz; Soe Soe Thwin; Ludovic Reveiz

doi:10.1016/j.tmaid.2023.102579

Associated factors for mortality in a COVID-19 colombian cohort: is the third wave relevant when Mu variant was predominant epidemiologically?

Carlos Alvarez-Moreno
, Sandra Liliana Valderrama-Beltran
, Ronaldo Silva
, Ilich Herbert De La Hoz Siegler
, Fabio Andrés Varón Vega
, Samuel Martínez-Vernaza
, Tatiana Ordoñez Blanco
, Mónica Padilla
, María Lucía Mesa-Rubio
, Laura Carmenza Castañeda Pascagaza
, José Antonio Rojas
, Juan Sebastián Bravo Ojeda
, Jaime Villa
, Julio Alberto Chacón Sarmiento
, Nancy Yomayusa
, Sandra Patiño
, Katherine Gómez-Nieto
, Viviana Lorena Martínez Pinzón
, Angélica María Ramírez Cogollo
, Carlos Toloza

Melissa Diaz-Puentes, Alejandra Cañas-Arboleda, Margarita Manrique-Andrade, Roberto Tarud Ayub, María José López Mora, María Julieta Pachón Espinosa, Jorge Alberto Cortés, Laura Catalina Sánchez, Kelly Rocío Chacón Acevedo, Paola Rengifo, Ginna Tambini, Silvia Bertagnolio, Janet Diaz, Soe Soe Thwin, Ludovic Reveiz

Department of Internal Medicine

Universidad Nacional de Colombia
Hospital Universitario San Ignacio
World Health Organization
Clínica Colsanitas
University Clinic
Universidad de los Andes Colombia
Clínica Universitaria Colombia. Fundación Universitaria Sanitas. Bogotá
Colsanitas
Clínica El Carmen
Clínica Reina Sofía
Santiago de Cali
Clínica Iberoamérica
Hospital Militar Central. Sante Fe
Unisanitas-Keralty
Pan American Health Organization

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Objectives: To evaluate the association between Colombia's third wave when the Mu variant was predominant epidemiologically (until 75%) in Colombia and COVID-19 all-cause in-hospital mortality. Methods: In this retrospective cohort, we included hospitalized patients ≥18 years with SARS-CoV-2 infection between March 2020 to September 2021 in ten hospitals from three cities in Colombia. Description analysis, survival, and multivariate Cox regression analyses were performed to evaluate the association between the third epidemic wave and in-hospital mortality. Results: A total of 25,371 patients were included. The age-stratified time-to-mortality curves showed differences according to epidemic waves in patients ≥75 years (log-rank test p = 0.012). In the multivariate Cox analysis, the third wave was not associated with increased mortality relative to the first wave (aHR 0.95; 95%CI 0.84–1.08), but there was an interaction between age ≥75 years and the third wave finding a lower HR for mortality (aHR 0.56, 95%CI 0.36–0.86). Conclusions: We did not find an increase in in-hospital mortality during the third epidemic wave in which the Mu variant was predominant in Colombia. The reduced hazard in mortality in patients ≥75 years hospitalized in the third wave could be explained by the high coverage of SARS-CoV-2 vaccination in this population and patients with underlying conditions.

Original language	English
Article number	102579
Journal	Travel Medicine and Infectious Disease
Volume	53
DOIs	https://doi.org/10.1016/j.tmaid.2023.102579
State	Published - 01 May 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Covid-19
Epidemic wave
Risk factors
Variant Mu

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10.1016/j.tmaid.2023.102579

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Alvarez-Moreno, C., Valderrama-Beltran, S. L., Silva, R., De La Hoz Siegler, I. H., Varón Vega, F. A., Martínez-Vernaza, S., Blanco, T. O., Padilla, M., Mesa-Rubio, M. L., Castañeda Pascagaza, L. C., Rojas, J. A., Bravo Ojeda, J. S., Villa, J., Chacón Sarmiento, J. A., Yomayusa, N., Patiño, S., Gómez-Nieto, K., Martínez Pinzón, V. L., Ramírez Cogollo, A. M., ... Reveiz, L. (2023). Associated factors for mortality in a COVID-19 colombian cohort: is the third wave relevant when Mu variant was predominant epidemiologically? Travel Medicine and Infectious Disease, 53, Article 102579. https://doi.org/10.1016/j.tmaid.2023.102579

@article{f7839056c4cc4c29a09f6621cc54a207,

title = "Associated factors for mortality in a COVID-19 colombian cohort: is the third wave relevant when Mu variant was predominant epidemiologically?",

abstract = "Objectives: To evaluate the association between Colombia's third wave when the Mu variant was predominant epidemiologically (until 75\%) in Colombia and COVID-19 all-cause in-hospital mortality. Methods: In this retrospective cohort, we included hospitalized patients ≥18 years with SARS-CoV-2 infection between March 2020 to September 2021 in ten hospitals from three cities in Colombia. Description analysis, survival, and multivariate Cox regression analyses were performed to evaluate the association between the third epidemic wave and in-hospital mortality. Results: A total of 25,371 patients were included. The age-stratified time-to-mortality curves showed differences according to epidemic waves in patients ≥75 years (log-rank test p = 0.012). In the multivariate Cox analysis, the third wave was not associated with increased mortality relative to the first wave (aHR 0.95; 95\%CI 0.84–1.08), but there was an interaction between age ≥75 years and the third wave finding a lower HR for mortality (aHR 0.56, 95\%CI 0.36–0.86). Conclusions: We did not find an increase in in-hospital mortality during the third epidemic wave in which the Mu variant was predominant in Colombia. The reduced hazard in mortality in patients ≥75 years hospitalized in the third wave could be explained by the high coverage of SARS-CoV-2 vaccination in this population and patients with underlying conditions.",

keywords = "Covid-19, Epidemic wave, Risk factors, Variant Mu",

author = "Carlos Alvarez-Moreno and Valderrama-Beltran, \{Sandra Liliana\} and Ronaldo Silva and \{De La Hoz Siegler\}, \{Ilich Herbert\} and \{Var{\'o}n Vega\}, \{Fabio Andr{\'e}s\} and Samuel Mart{\'i}nez-Vernaza and Blanco, \{Tatiana Ordo{\~n}ez\} and M{\'o}nica Padilla and Mesa-Rubio, \{Mar{\'i}a Luc{\'i}a\} and \{Casta{\~n}eda Pascagaza\}, \{Laura Carmenza\} and Rojas, \{Jos{\'e} Antonio\} and \{Bravo Ojeda\}, \{Juan Sebasti{\'a}n\} and Jaime Villa and \{Chac{\'o}n Sarmiento\}, \{Julio Alberto\} and Nancy Yomayusa and Sandra Pati{\~n}o and Katherine G{\'o}mez-Nieto and \{Mart{\'i}nez Pinz{\'o}n\}, \{Viviana Lorena\} and \{Ram{\'i}rez Cogollo\}, \{Ang{\'e}lica Mar{\'i}a\} and Carlos Toloza and Melissa Diaz-Puentes and Alejandra Ca{\~n}as-Arboleda and Margarita Manrique-Andrade and Ayub, \{Roberto Tarud\} and \{L{\'o}pez Mora\}, \{Mar{\'i}a Jos{\'e}\} and \{Pach{\'o}n Espinosa\}, \{Mar{\'i}a Julieta\} and Cort{\'e}s, \{Jorge Alberto\} and S{\'a}nchez, \{Laura Catalina\} and \{Chac{\'o}n Acevedo\}, \{Kelly Roc{\'i}o\} and Paola Rengifo and Ginna Tambini and Silvia Bertagnolio and Janet Diaz and Thwin, \{Soe Soe\} and Ludovic Reveiz",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = may,

day = "1",

doi = "10.1016/j.tmaid.2023.102579",

language = "English",

volume = "53",

journal = "Travel Medicine and Infectious Disease",

issn = "1477-8939",

publisher = "Elsevier Inc.",

}

Alvarez-Moreno, C, Valderrama-Beltran, SL, Silva, R, De La Hoz Siegler, IH, Varón Vega, FA, Martínez-Vernaza, S, Blanco, TO, Padilla, M, Mesa-Rubio, ML, Castañeda Pascagaza, LC, Rojas, JA, Bravo Ojeda, JS, Villa, J, Chacón Sarmiento, JA, Yomayusa, N, Patiño, S, Gómez-Nieto, K, Martínez Pinzón, VL, Ramírez Cogollo, AM, Toloza, C, Diaz-Puentes, M, Cañas-Arboleda, A, Manrique-Andrade, M, Ayub, RT, López Mora, MJ, Pachón Espinosa, MJ, Cortés, JA, Sánchez, LC, Chacón Acevedo, KR, Rengifo, P, Tambini, G, Bertagnolio, S, Diaz, J, Thwin, SS & Reveiz, L 2023, 'Associated factors for mortality in a COVID-19 colombian cohort: is the third wave relevant when Mu variant was predominant epidemiologically?', Travel Medicine and Infectious Disease, vol. 53, 102579. https://doi.org/10.1016/j.tmaid.2023.102579

TY - JOUR

T1 - Associated factors for mortality in a COVID-19 colombian cohort

T2 - is the third wave relevant when Mu variant was predominant epidemiologically?

AU - Alvarez-Moreno, Carlos

AU - Valderrama-Beltran, Sandra Liliana

AU - Silva, Ronaldo

AU - De La Hoz Siegler, Ilich Herbert

AU - Varón Vega, Fabio Andrés

AU - Martínez-Vernaza, Samuel

AU - Blanco, Tatiana Ordoñez

AU - Padilla, Mónica

AU - Mesa-Rubio, María Lucía

AU - Castañeda Pascagaza, Laura Carmenza

AU - Rojas, José Antonio

AU - Bravo Ojeda, Juan Sebastián

AU - Villa, Jaime

AU - Chacón Sarmiento, Julio Alberto

AU - Yomayusa, Nancy

AU - Patiño, Sandra

AU - Gómez-Nieto, Katherine

AU - Martínez Pinzón, Viviana Lorena

AU - Ramírez Cogollo, Angélica María

AU - Toloza, Carlos

AU - Diaz-Puentes, Melissa

AU - Cañas-Arboleda, Alejandra

AU - Manrique-Andrade, Margarita

AU - Ayub, Roberto Tarud

AU - López Mora, María José

AU - Pachón Espinosa, María Julieta

AU - Cortés, Jorge Alberto

AU - Sánchez, Laura Catalina

AU - Chacón Acevedo, Kelly Rocío

AU - Rengifo, Paola

AU - Tambini, Ginna

AU - Bertagnolio, Silvia

AU - Diaz, Janet

AU - Thwin, Soe Soe

AU - Reveiz, Ludovic

PY - 2023/5/1

Y1 - 2023/5/1

N2 - Objectives: To evaluate the association between Colombia's third wave when the Mu variant was predominant epidemiologically (until 75%) in Colombia and COVID-19 all-cause in-hospital mortality. Methods: In this retrospective cohort, we included hospitalized patients ≥18 years with SARS-CoV-2 infection between March 2020 to September 2021 in ten hospitals from three cities in Colombia. Description analysis, survival, and multivariate Cox regression analyses were performed to evaluate the association between the third epidemic wave and in-hospital mortality. Results: A total of 25,371 patients were included. The age-stratified time-to-mortality curves showed differences according to epidemic waves in patients ≥75 years (log-rank test p = 0.012). In the multivariate Cox analysis, the third wave was not associated with increased mortality relative to the first wave (aHR 0.95; 95%CI 0.84–1.08), but there was an interaction between age ≥75 years and the third wave finding a lower HR for mortality (aHR 0.56, 95%CI 0.36–0.86). Conclusions: We did not find an increase in in-hospital mortality during the third epidemic wave in which the Mu variant was predominant in Colombia. The reduced hazard in mortality in patients ≥75 years hospitalized in the third wave could be explained by the high coverage of SARS-CoV-2 vaccination in this population and patients with underlying conditions.

AB - Objectives: To evaluate the association between Colombia's third wave when the Mu variant was predominant epidemiologically (until 75%) in Colombia and COVID-19 all-cause in-hospital mortality. Methods: In this retrospective cohort, we included hospitalized patients ≥18 years with SARS-CoV-2 infection between March 2020 to September 2021 in ten hospitals from three cities in Colombia. Description analysis, survival, and multivariate Cox regression analyses were performed to evaluate the association between the third epidemic wave and in-hospital mortality. Results: A total of 25,371 patients were included. The age-stratified time-to-mortality curves showed differences according to epidemic waves in patients ≥75 years (log-rank test p = 0.012). In the multivariate Cox analysis, the third wave was not associated with increased mortality relative to the first wave (aHR 0.95; 95%CI 0.84–1.08), but there was an interaction between age ≥75 years and the third wave finding a lower HR for mortality (aHR 0.56, 95%CI 0.36–0.86). Conclusions: We did not find an increase in in-hospital mortality during the third epidemic wave in which the Mu variant was predominant in Colombia. The reduced hazard in mortality in patients ≥75 years hospitalized in the third wave could be explained by the high coverage of SARS-CoV-2 vaccination in this population and patients with underlying conditions.

KW - Covid-19

KW - Epidemic wave

KW - Risk factors

KW - Variant Mu

UR - https://www.scopus.com/pages/publications/85159233622

U2 - 10.1016/j.tmaid.2023.102579

DO - 10.1016/j.tmaid.2023.102579

M3 - Article

C2 - 37169233

AN - SCOPUS:85159233622

SN - 1477-8939

VL - 53

JO - Travel Medicine and Infectious Disease

JF - Travel Medicine and Infectious Disease

M1 - 102579

ER -

Associated factors for mortality in a COVID-19 colombian cohort: is the third wave relevant when Mu variant was predominant epidemiologically?

Abstract

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Keywords

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