Antimycobacterial activity of pyrimido[4,5-b]diazepine derivatives

Braulio Insuasty; Angélica García; Juan Bueno; Jairo Quiroga; Rodrigo Abonia; Alejandro Ortiz

doi:10.1002/ardp.201100433

Antimycobacterial activity of pyrimido[4,5-b]diazepine derivatives

Braulio Insuasty
, Angélica García
, Juan Bueno
, Jairo Quiroga
, Rodrigo Abonia
, Alejandro Ortiz

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Three series of novel 8,9-dihydro-7H-pyrimido[5,4-b][1,4]diazepines, 4a-d, 5a-d, and 7a-d, were efficiently obtained in good yields using simple reaction methodologies. These pyrimidodiazepines were evaluated against 15 Mycobacterium spp. strains. Moderate activity in the inhibition of 13 microorganisms was obtained for the four compounds 4a, 5a, 5c, and 5d.

Original language	English
Pages (from-to)	739-744
Number of pages	6
Journal	Archiv der Pharmazie
Volume	345
Issue number	9
DOIs	https://doi.org/10.1002/ardp.201100433
State	Published - Sep 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

4,5-Diaminopyrimidines
Methylenedioxychalcones
Pyrimido[4,5-b]diazepine
Tuberculosis

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10.1002/ardp.201100433

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title = "Antimycobacterial activity of pyrimido[4,5-b]diazepine derivatives",

abstract = "Three series of novel 8,9-dihydro-7H-pyrimido[5,4-b][1,4]diazepines, 4a-d, 5a-d, and 7a-d, were efficiently obtained in good yields using simple reaction methodologies. These pyrimidodiazepines were evaluated against 15 Mycobacterium spp. strains. Moderate activity in the inhibition of 13 microorganisms was obtained for the four compounds 4a, 5a, 5c, and 5d.",

keywords = "4,5-Diaminopyrimidines, Methylenedioxychalcones, Pyrimido[4,5-b]diazepine, Tuberculosis",

author = "Braulio Insuasty and Ang{\'e}lica Garc{\'i}a and Juan Bueno and Jairo Quiroga and Rodrigo Abonia and Alejandro Ortiz",

year = "2012",

month = sep,

doi = "10.1002/ardp.201100433",

language = "English",

volume = "345",

pages = "739--744",

journal = "Archiv der Pharmazie",

issn = "0365-6233",

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}

TY - JOUR

T1 - Antimycobacterial activity of pyrimido[4,5-b]diazepine derivatives

AU - Insuasty, Braulio

AU - García, Angélica

AU - Bueno, Juan

AU - Quiroga, Jairo

AU - Abonia, Rodrigo

AU - Ortiz, Alejandro

PY - 2012/9

Y1 - 2012/9

N2 - Three series of novel 8,9-dihydro-7H-pyrimido[5,4-b][1,4]diazepines, 4a-d, 5a-d, and 7a-d, were efficiently obtained in good yields using simple reaction methodologies. These pyrimidodiazepines were evaluated against 15 Mycobacterium spp. strains. Moderate activity in the inhibition of 13 microorganisms was obtained for the four compounds 4a, 5a, 5c, and 5d.

AB - Three series of novel 8,9-dihydro-7H-pyrimido[5,4-b][1,4]diazepines, 4a-d, 5a-d, and 7a-d, were efficiently obtained in good yields using simple reaction methodologies. These pyrimidodiazepines were evaluated against 15 Mycobacterium spp. strains. Moderate activity in the inhibition of 13 microorganisms was obtained for the four compounds 4a, 5a, 5c, and 5d.

KW - 4,5-Diaminopyrimidines

KW - Methylenedioxychalcones

KW - Pyrimido[4,5-b]diazepine

KW - Tuberculosis

UR - https://www.scopus.com/pages/publications/84866236693

U2 - 10.1002/ardp.201100433

DO - 10.1002/ardp.201100433

M3 - Article

C2 - 22730136

AN - SCOPUS:84866236693

SN - 0365-6233

VL - 345

SP - 739

EP - 744

JO - Archiv der Pharmazie

JF - Archiv der Pharmazie

IS - 9

ER -

Antimycobacterial activity of pyrimido[4,5-b]diazepine derivatives

Abstract

UN SDGs

Keywords

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