An anterograde degeneration study of the distribution of regenerating rat myelinated fibers in the silicone chamber model

L. H. Alzate, J. J. Sutachan, H. Hurtado

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Specificity of reinnervation after a peripheral nerve lesion has given rise to considerable controversy. As a contribution to solving this issue we have evaluated the specificity of reinnervation of the peroneal nerve after a complete transection of the sciatic nerve repaired with an 8 mm silicone tube, leaving a 4 mm gap between the nerve stumps. Our findings reveal unspecificity of reinnervation of the distal peroneal branch. This lack of specificity is shown by a random distribution of fibers originating from both proximal branches at the level of the tube and at distal peroneal and tibial branches, argue against specificity of regeneration in this model. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalNeuroscience Letters
Volume286
Issue number1
DOIs
StatePublished - 26 May 2000
Externally publishedYes

Keywords

  • Entubation
  • Peripheral nerve
  • Rat
  • Regeneration
  • Reinnervation specificity

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