Abstract
Objective: To evaluate the impact on the incidence and recurrence of cardiovascular and cerebrovascular events (primary and secondary prevention), the levels of lipid fractions and the
incidence of side effects in people with hypercholesterolemia intolerant to statin therapy.
Methods: A clinical practice guideline was developed following the guidelines of the methodological guidance of the Ministry of Health and Social Protection to systematically collect the
evidence and make recommendations using the GRADE methodology.
Population: Adult population, diagnosed with dyslipidemia or at risk of developing, intolerant
to management with statin drugs.
Recommendations: Recommendations for the use of different medications (fibrates, niacin,
omega 3 acids, bile acid binding resins, ezetimibe) are formulated according to their lipidlowering effectiveness and reduction of cardiovascular events, a proposal adapted to the
Colombian social context.
© 2014 Sociedad Colombiana de Cardiología y Cirugía Cardiovascular. Published by Elsevier España, S.L.U. This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/).
incidence of side effects in people with hypercholesterolemia intolerant to statin therapy.
Methods: A clinical practice guideline was developed following the guidelines of the methodological guidance of the Ministry of Health and Social Protection to systematically collect the
evidence and make recommendations using the GRADE methodology.
Population: Adult population, diagnosed with dyslipidemia or at risk of developing, intolerant
to management with statin drugs.
Recommendations: Recommendations for the use of different medications (fibrates, niacin,
omega 3 acids, bile acid binding resins, ezetimibe) are formulated according to their lipidlowering effectiveness and reduction of cardiovascular events, a proposal adapted to the
Colombian social context.
© 2014 Sociedad Colombiana de Cardiología y Cirugía Cardiovascular. Published by Elsevier España, S.L.U. This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/).
| Translated title of the contribution | Therapeutic alternatives to pharmacological management with statin drugs in adults with dyslipidemia: Systematic literature review and general recommendations |
|---|---|
| Original language | Spanish |
| Pages (from-to) | 179-186 |
| Number of pages | 8 |
| Journal | Revista Colombiana de Cardiologia |
| Volume | 22 |
| Issue number | 4 |
| DOIs | |
| State | Published - 06 Jun 2015 |
Keywords
- Cardiovascular disease
- Hypercholesterolemia
- Lipids
- Treatment
- Statins
