TY - JOUR
T1 - Agreement Between Cardiovascular Risk Assessment Models (SCORE2, Framingham, ASCVD-2013, and SCORE2-OP) in Adults Aged 70 Years or Older
T2 - A Population-Based Study
AU - Porras Bueno, Cristian Orlando
AU - Lindarte Vargas, Hector Henry
AU - Ravagli Baquero, Maria Paula
AU - Gil, Fabian
AU - Muñoz Velandia, Oscar Mauricio
AU - García Peña, Ángel Alberto
N1 - Publisher Copyright:
© The Author(s) 2025. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
PY - 2025/12/15
Y1 - 2025/12/15
N2 - BACKGROUND: Despite several prediction models to estimate cardiovascular risk (CVR) being available, most have been developed and validated in populations under 70 years of age. To improve this estimation in older adults aged 70 years or older, the SCORE2-OP model was developed; however, its application outside Europe may under- or overestimate true CVR.OBJECTIVE: To assess the concordance between the CVR measured by 4 widely used CVR tools (Framingham, ASCVD-2013, SCORE2) and the SCORE2-OP in older adults aged ⩾ 70 years.METHODS: Secondary analysis of adults aged ⩾ 70 years from the SABE Colombia study, which was conducted between April and September 2015. The concordance between the 4 different CVR prediction models and SCORE2-OP was assessed via Cohen's quadratically weighted kappa coefficient and Lin's concordance correlation coefficient.RESULTS: Among the 23 694 participants in the SABE Colombia study, 23 108 were excluded due to insufficient data to estimate the CVR for any of the tools evaluated. 586 individuals met the inclusion criteria and were analyzed. The concordance between the ASCVD-2013 (weighted kappa 0.24; 95% CI 0.22-0.26) and Framingham algorithms (0.22; 95% CI 0.20-0.24) calibrated to the Colombian population and SCORE2-OP were both classified as fair. In contrast, agreement between SCORE2 calibrated for Colombia and SCORE2-OP reached a moderate level (0.43; 95% CI 0.40-0.46). Higher values were observed compared with the SCORE2-OP model developed for intermediate-risk regions.CONCLUSIONS: Our results suggest that, among adults aged ⩾ 70 years, there is variable agreement between widely used CVR prediction models and SCORE2-OP, with the latter overestimating CVR compared to nationally validated CVR scores. This highlights the need for region-specific validation to ensure accurate estimation of CVR in this population.
AB - BACKGROUND: Despite several prediction models to estimate cardiovascular risk (CVR) being available, most have been developed and validated in populations under 70 years of age. To improve this estimation in older adults aged 70 years or older, the SCORE2-OP model was developed; however, its application outside Europe may under- or overestimate true CVR.OBJECTIVE: To assess the concordance between the CVR measured by 4 widely used CVR tools (Framingham, ASCVD-2013, SCORE2) and the SCORE2-OP in older adults aged ⩾ 70 years.METHODS: Secondary analysis of adults aged ⩾ 70 years from the SABE Colombia study, which was conducted between April and September 2015. The concordance between the 4 different CVR prediction models and SCORE2-OP was assessed via Cohen's quadratically weighted kappa coefficient and Lin's concordance correlation coefficient.RESULTS: Among the 23 694 participants in the SABE Colombia study, 23 108 were excluded due to insufficient data to estimate the CVR for any of the tools evaluated. 586 individuals met the inclusion criteria and were analyzed. The concordance between the ASCVD-2013 (weighted kappa 0.24; 95% CI 0.22-0.26) and Framingham algorithms (0.22; 95% CI 0.20-0.24) calibrated to the Colombian population and SCORE2-OP were both classified as fair. In contrast, agreement between SCORE2 calibrated for Colombia and SCORE2-OP reached a moderate level (0.43; 95% CI 0.40-0.46). Higher values were observed compared with the SCORE2-OP model developed for intermediate-risk regions.CONCLUSIONS: Our results suggest that, among adults aged ⩾ 70 years, there is variable agreement between widely used CVR prediction models and SCORE2-OP, with the latter overestimating CVR compared to nationally validated CVR scores. This highlights the need for region-specific validation to ensure accurate estimation of CVR in this population.
KW - cross-sectional studies
KW - geriatrics
KW - heart disease risk factors
KW - primary health care
KW - risk assessment
UR - https://www.scopus.com/pages/publications/105024961636
UR - https://www.mendeley.com/catalogue/e5df96a1-89a6-30d9-945c-5e8ef1b61f34/
U2 - 10.1177/11795468251406976
DO - 10.1177/11795468251406976
M3 - Article
C2 - 41409342
SN - 1179-5468
VL - 19
SP - 11795468251406976
JO - Clinical Medicine Insights: Cardiology
JF - Clinical Medicine Insights: Cardiology
ER -